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Department of

Surgery

Photo of Dorothy Supp, PhD

Dorothy Supp, PhD

Research Professor (Adjunct); Investigator, Shriners Hospitals for Children - Cincinnati

Education/Credentials
  • B.S.: Cornell University, College of Agriculture and Life Sciences
  • PhD.: University of Cincinnati College of Medicine
  • Postdoctoral Fellowship: Childrens Hospital Research Foundation
Contact Information
  • Shriners Hospitals for Children - Cincinnati
  • 3229 Burnet Avenue
  • Cincinnati, Ohio 45229-3095
  • Email dorothy.supp@uc.edu

Peer Reviewed Publications

Kim, Jayne Y; Willard, James J; Supp, Dorothy M; Roy, Sashwati; Gordillo, Gayle M; Sen, Chandan K; Powell, Heather M 2015. Burn Scar Biomechanics Following Pressure Garment Therapy. Plastic and reconstructive surgery, ,

Alexander, J Wesley; Supp, Dorothy M 2014. Role of Arginine and Omega-3 Fatty Acids in Wound Healing and Infection. Advances in wound care, 3 11, 682-690

Boyce, Steven T; Zimmerman, Rachel L; Supp, Dorothy M 2014. Tumorigenicity Testing in Athymic Mice of Cultured Human Melanocytes for Transplantation in Engineered Skin Substitutes. Cell transplantation, ,

Osterburg, Andrew R; Hexley, Philip; Supp, Dorothy M; Robinson, Chad T; Noel, Greg; Ogle, Cora; Boyce, Steven T; Aronow, Bruce J; Babcock, George F 2013. Concerns over interspecies transcriptional comparisons in mice and humans after trauma. Proceedings of the National Academy of Sciences of the United States of America, 110 36, E3370

Sriwiriyanont, Penkanok; Lynch, Kaari A; McFarland, Kevin L; Supp, Dorothy M; Boyce, Steven T 2013. Characterization of hair follicle development in engineered skin substitutes. PloS one, 8 6, e65664

Sriwiriyanont, Penkanok; Lynch, Kaari A; Maier, Elizabeth A; Hahn, Jennifer M; Supp, Dorothy M; Boyce, Steven T 2012. Morphogenesis of chimeric hair follicles in engineered skin substitutes with human keratinocytes and murine dermal papilla cells. Experimental dermatology, 21 10, 783-5

Supp, Dorothy M 2012. Genomic Reprogramming and Skin-Like Maturation of Engineered Human Skin Substitutes. Advances in wound care, 1 2, 63-68

Supp, Dorothy M; Glaser, Kathryn; Hahn, Jennifer M; McFarland, Kevin L; Boyce, Steven T 2012. LETTER TO THE EDITOR Abnormal Responses of Keloid Tissue to Wounding Identified Using In Vitro Model System. Eplasty, 12 , e19

Supp, Dorothy M; Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Boyce, Steven T 2012. Deep and superficial keloid fibroblasts contribute differentially to tissue phenotype in a novel in vivo model of keloid scar. Plastic and reconstructive surgery, 129 6, 1259-71

Swope, Viki B; Jameson, Joshua A; McFarland, Kevin L; Supp, Dorothy M; Miller, William E; McGraw, Dennis W; Patel, Mira A; Nix, Matthew A; Millhauser, Glenn L; Babcock, George F; Abdel-Malek, Zalfa A 2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti signaling protein and ?-defensin 3. The Journal of investigative dermatology, 132 9, 2255-62

Klingenberg, Jennifer M; McFarland, Kevin L; Friedman, Aaron J; Boyce, Steven T; Aronow, Bruce J; Supp, Dorothy M 2010. Engineered human skin substitutes undergo large-scale genomic reprogramming and normal skin-like maturation after transplantation to athymic mice. The Journal of investigative dermatology, 130 2, 587-601

Powell, Heather M; McFarland, Kevin L; Butler, David L; Supp, Dorothy M; Boyce, Steven T 2010. Uniaxial strain regulates morphogenesis, gene expression, and tissue strength in engineered skin. Tissue engineering. Part A, 16 3, 1083-92

Supp, Dorothy M; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N 2009. Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4. Burns : journal of the International Society for Burn Injuries, 35 7, 949-55

Kalyanaraman, Balaji; Supp, Dorothy M; Boyce, Steven T 2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusion culture. Tissue engineering. Part A, 14 5, 583-93

Powell, Heather M; Supp, Dorothy M; Boyce, Steven T 2008. Influence of electrospun collagen on wound contraction of engineered skin substitutes. Biomaterials, 29 7, 834-43

Fang, Cheng-Hui; Li, Bingguo; James, J Howard; Yahya, Ayesha; Kadeer, Nijiati; Guo, Xialing; Xiao, Chun; Supp, Dorothy M; Kagan, Richard J; Hasselgren, Per-Olof; Sheriff, Sulaiman 2007. GSK-3beta activity is increased in skeletal muscle after burn injury in rats. American journal of physiology. Regulatory, integrative and comparative physiology, 293 4, R1545-51

Supp, Dorothy M 2007. Gene therapy to fight infection in skin transplants. Pharmacogenomics, 8 5, 483-6

Smiley, Andrea K; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M 2006. Keratin expression in cultured skin substitutes suggests that the hyperproliferative phenotype observed in vitro is normalized after grafting. Burns : journal of the International Society for Burn Injuries, 32 2, 135-8

Smiley, Andrea K; Klingenberg, Jennifer M; Aronow, Bruce J; Boyce, Steven T; Kitzmiller, W John; Supp, Dorothy M 2005. Microarray analysis of gene expression in cultured skin substitutes compared with native human skin. The Journal of investigative dermatology, 125 6, 1286-301

Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T 2004. Expression of human beta-defensins HBD-1, HBD-2, and HBD-3 in cultured keratinocytes and skin substitutes. Burns : journal of the International Society for Burn Injuries, 30 7, 643-8

Supp, Dorothy M; Wilson-Landy, Kaila; Boyce, Steven T 2002. Human dermal microvascular endothelial cells form vascular analogs in cultured skin substitutes after grafting to athymic mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 8, 797-804

Supp, D M; Supp, A P; Bell, S M; Boyce, S T 2000. Enhanced vascularization of cultured skin substitutes genetically modified to overexpress vascular endothelial growth factor. The Journal of investigative dermatology, 114 1, 5-13

Abdel-Malek Z.; Boyce S.; Kleiner M.; Lloyd C.; Supp D.; Swope V. 11-01-2017. Restoration of cutaneous pigmentation by transplantation to mice of isogeneic human melanocytes in d Pigment Cell and Melanoma Research, 30 6, 531-540

Hahn J.; Supp D. 11-01-2017. Abnormal expression of the vitamin D receptor in keloid scars Burns, 43 7, 1506-1515

Allan S.; Boyce S.; Forouzandeh F.; Ghahary A.; Hartwell R.; Jalili R.; Supp D. 11-01-2010. Local expression of indoleamine 2,3-dioxygenase suppresses T-cell-mediated rejection of an engineere Wound Repair and Regeneration, 18 6, 614-623

Blackstone B.; DeBruler D.; Hahn J.; McFarland K.; Powell H.; Supp D. 10-15-2018. Inflammatory response and biomechanical properties of coaxial scaffolds for engineered skin in vitro Acta Biomaterialia, 80 , 247-257

Boissy R.; Boyce S.; Combs K.; Hahn J.; Lucky A.; McFarland K.; Powell H.; Schwentker A.; Supp D. 09-01-2019. Collagen VII Expression Is Required in Both Keratinocytes and Fibroblasts for Anchoring Fibril Forma Cell Transplantation, 28 9-10, 1242-1256

Bailey J.; Baumann M.; Blackstone B.; DeBruler D.; McFarland K.; Powell H.; Supp D.; Wilgus T.; Wulff B. 09-01-2017. Inflammatory responses, matrix remodeling, and re-epithelialization after fractional CO<inf>2& Lasers in Surgery and Medicine, 49 7, 675-685

Boyce S.; Chen X.; He H.; Kopan R.; Lander J.; Martin L.; Supp D.; Weirauch M. 09-01-2017. Analysis of chromatin accessibility in human epidermis identifies putative barrier dysfunction-sensi PLoS ONE, 12 9,

Bailey J.; Blackstone B.; Kim J.; McFarland K.; Powell H.; Sen C.; Supp D. 07-01-2017. Scar formation following excisional and burn injuries in a red Duroc pig model Wound Repair and Regeneration, 25 4, 618-631

Bailey J.; Blackstone B.; Clark J.; Kim J.; Malara M.; Powell H.; Ruegsegger M.; Supp D. 06-13-2018. Structural, Chemical, and Mechanical Properties of Pressure Garments as a Function of Simulated Use Journal of Burn Care and Research, 39 4, 562-571

Bailey J.; Baumann M.; Blackstone B.; DeBruler D.; Malara M.; Powell H.; Supp D.; Zbinden J. 06-01-2018. Early cessation of pressure garment therapy results in scar contraction and thickening PLoS ONE, 13 6,

Bailey J.; Baumann M.; Blackstone B.; DeBruler D.; McFarland K.; Powell H.; Supp D. 06-01-2018. Effect of skin graft thickness on scar development in a porcine burn model Burns, 44 4, 917-930

Boyce S.; Kalyanaraman B.; Supp D. 05-01-2008. Medium flow rate regulates viability and barrier function of engineered skin substitutes in perfusio Tissue Engineering - Part A., 14 5, 583-593

Boyce S.; Supp D. 04-19-2016. Bioengineering of human skin substitutes Tissue Engineering and Artificial Organs, , 715-731

Supp D. 04-01-2011. Skin substitutes for burn wound healing: Current and future approaches Expert Review of Dermatology, 6 2, 217-227

Boyce S.; Combs K.; Hahn J.; Lloyd C.; McFarland K.; Supp D. 03-01-2019. Identification of Merkel cells associated with neurons in engineered skin substitutes after grafting PLoS ONE, 14 3,

Dunham D.; Kim J.; Powell H.; Sen C.; Supp D. 03-01-2016. Novel burn device for rapid, reproducible burn wound generation Burns, 42 2, 384-391

Boyce S.T.; Lloyd C.M.; Supp D.M. 02-01-2020. Exogenous Keratinocyte Growth Factor Is Not Required for Pigmentation of Skin Substitutes with Three Tissue Engineering - Part A, 26 3-4, 214-224

Bailey J.; Baumann M.; Blackstone B.; Debruler D.; McFarland K.; Powell H.; Supp D.; Zbinden J. 02-01-2019. Role of Early Application of Pressure Garments following Burn Injury and Autografting Plastic and Reconstructive Surgery, 143 2, 310e-321e

Supp D. 02-01-2019. Animal Models for Studies of Keloid Scarring Advances in Wound Care, 8 2, 77-89

Abdel-Malek Z.; Supp D. 02-01-2008. ?-Defensin 3: A novel and unexpected key that unlocks the melanocortin 1 receptor Pigment Cell and Melanoma Research, 21 1, 7-8

Neely A.; Supp D. 02-01-2008. Cutaneous antimicrobial gene therapy: Engineering human skin replacements to combat wound infection Expert Review of Dermatology, 3 1, 73-84

Baumann M.; Blackstone B.; Malara M.; McFarland K.; Powell H.; Supp D. 01-15-2020. Fractional CO<inf>2</inf> laser micropatterning of cell-seeded electrospun collagen scaf Acta Biomaterialia, 102 , 287-297

Bailey J.; Baumann M.; Blackstone B.; Clairmonte I.; Malara M.; Powell H.; Supp D. 01-01-2019. Fractional CO<inf>2</inf> laser ablation of porcine burn scars after grafting: Is deeper Burns, ,

Bailey J.; Baumann M.; Blackstone B.; DeBruler D.; Imeokparia F.; Kim J.; McFarland K.; Powell H.; Supp D. 01-01-2018. Effects of early combinatorial treatment of autologous split-thickness skin grafts in red duroc pig Lasers in Surgery and Medicine, 50 1, 78-87

Boyce S.; Combs K.; Hahn J.; Hammock B.; Inceoglu B.; Lee K.; McFarland K.; Supp D.; Wan D. 01-01-2016. Soluble epoxide hydrolase inhibition and epoxyeicosatrienoic acid treatment improve vascularization Plastic and Reconstructive Surgery - Global Open, 4 12,

Boyce S.; Supp D. 01-01-2016. Biologic Skin Substitutes Skin Tissue Engineering and Regenerative Medicine, , 211-238

Abdel-Malek Z.A.; Babcock G.F.; Jameson J.A.; McFarland K.L.; McGraw D.W.; Miller W.E.; Millhauser G.L.; Nix M.A.; Patel M.A.; Supp D.M.; Swope V.B. 01-01-2012. Defining MC1R regulation in human melanocytes by its agonist ?-melanocortin and antagonists agouti s Journal of Investigative Dermatology, 132 9, 2255-2262

Abdel-Malek Z.A.; Babcock G.; Boissy R.E.; Cassidy P.; Ito S.; Kadekaro A.L.; Kavanagh R.J.; Koshoffer A.; Leachman S.; Manga P.; Sartor M.; Schwemberger S.; Sturm R.A.; Supp D.; Swope V.; Wakamatsu K. 01-01-2010. Melanocortin 1 receptor genotype: An important determinant of the damage response of melanocytes to FASEB Journal, 24 10, 3850-3860

Boyce S.; Supp D. 01-01-2007. Bioengineering of human skin substitutes Tissue Engineering, , 275-291

Boyce, Steven T; Rice, Rachel K; Lynch, Kaari A; Supp, Andrew P; Swope, Viki B; Kagan, Richard J; Supp, Dorothy M . Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 20 4, 544-51

Hahn, Jennifer M; Glaser, Kathryn; McFarland, Kevin L; Aronow, Bruce J; Boyce, Steven T; Supp, Dorothy M . Keloid-derived keratinocytes exhibit an abnormal gene expression profile consistent with a distinct causal role in keloid pathology. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 21 4, 530-44

McFarland, Kevin L; Glaser, Kathryn; Hahn, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Culture medium and cell density impact gene expression in normal skin and abnormal scar-derived fibroblasts. Journal of burn care & research : official publication of the American Burn Association, 32 4, 498-508

McFarland, Kevin L; Klingenberg, Jennifer M; Boyce, Steven T; Supp, Dorothy M . Expression of genes encoding antimicrobial proteins and members of the toll-like receptor/nuclear factor-kappaB pathways in engineered human skin. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 16 4, 534-41

Smiley, Andrea K; Gardner, Jason; Klingenberg, Jennifer M; Neely, Alice N; Supp, Dorothy M . Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity. Journal of burn care & research : official publication of the American Burn Association, 28 1, 127-32

Supp, Andrew P; Neely, Alice N; Supp, Dorothy M; Warden, Glenn D; Boyce, Steven T . Evaluation of cytotoxicity and antimicrobial activity of Acticoat Burn Dressing for management of microbial contamination in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 26 3, 238-46

Supp, D M; Bell, S M; Morgan, J R; Boyce, S T . Genetic modification of cultured skin substitutes by transduction of human keratinocytes and fibroblasts with platelet-derived growth factor-A. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 8 1, 26-35

Supp, Dorothy M; Boyce, Steven T . Engineered skin substitutes: practices and potentials. Clinics in dermatology, 23 4, 403-12

Supp, Dorothy M; Boyce, Steven T . Overexpression of vascular endothelial growth factor accelerates early vascularization and improves healing of genetically modified cultured skin substitutes. The Journal of burn care & rehabilitation, 23 1, 10-20

Supp, Dorothy M; Hahn, Jennifer M; McFarland, Kevin L; Glaser, Kathryn . Inhibition of hyaluronan synthase 2 reduces the abnormal migration rate of keloid keratinocytes. Journal of burn care & research : official publication of the American Burn Association, 35 1, 84-92

Supp, Dorothy M; Karpinski, Andrea C; Boyce, Steven T . Vascular endothelial growth factor overexpression increases vascularization by murine but not human endothelial cells in cultured skin substitutes grafted to athymic mice. The Journal of burn care & rehabilitation, 25 4, 337-45