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Department of

Pathology and Laboratory Medicine

Photo of  Kathryn Wikenheiser-Brokamp, MD, PhD

Kathryn Wikenheiser-Brokamp, MD, PhD

Associate Professor

Education/Credentials
  • Medical Degree: University of Cincinnati College of Medicine
  • Doctorate: Cincinnati Children's Hospital Medical Center/University of Cincinnati College of Medicine
  • Residency: Washington University-Barnes/Jewish Hospital
  • Clinical Trainee: Washington University
Contact Information
  • UC Institute Member Seal

Peer Reviewed Publications

Akeno, Nagako; Reece, Alisa L; Callahan, Melissa; Miller, Ashley L; Kim, Rebecca G; He, Diana; Lane, Adam; Moulton, Jonathan S; Wikenheiser-Brokamp, Kathryn A 2017. Trp53 Mutants Drive Neuroendocrine Lung Cancer through Loss-of-Function Mechanisms with Gain-of-Function Effects on Chemotherapy Response. Molecular cancer therapeutics, ,

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Molecular cancer research : MCR, 15 10, 1318-1330

Nalapareddy, Kodandaramireddy; Nattamai, Kalpana J; Kumar, Rupali S; Karns, Rebekah; Wikenheiser-Brokamp, Kathryn A; Sampson, Leesa L; Mahe, Maxime M; Sundaram, Nambirajan; Yacyshyn, Mary-Beth; Yacyshyn, Bruce; Helmrath, Michael A; Zheng, Yi; Geiger, Hartmut 2017. Canonical Wnt Signaling Ameliorates Aging of Intestinal Stem Cells. Cell reports, 18 11, 2608-2621

Sen, M; Akeno, N; Reece, A; Miller, A L; Simpson, D S; Wikenheiser-Brokamp, K A 2017. p16 controls epithelial cell growth and suppresses carcinogenesis through mechanisms that do not require RB1 function. Oncogenesis, 6 4, e320

Sriprasart, Thitiwat; Aragaki, Alejandro; Baughman, Robert; Wikenheiser-Brokamp, Kathryn; Khanna, Gaurav; Tanase, Daniel; Kirschner, Michelle; Benzaquen, Sadia 2017. A Single US Center Experience of Transbronchial Lung Cryobiopsy for Diagnosing Interstitial Lung Disease With a 2-Scope Technique. Journal of bronchology & interventional pulmonology, 24 2, 131-135

Wikenheiser-Brokamp, Kathryn A; Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; DeWitt, Thomas G; Loch, Jill; Strauss, Arnold W; Muglia, Louis J; Hostetter, Margaret K 2017. Evaluation of Fellows' CrossTalk Effectiveness in Promoting Transdisciplinary Networking and Research. The Journal of pediatrics, 181 , 5-6.e3

Chlon, Timothy M; Ruiz-Torres, Sonya; Maag, Logan; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2016. Overcoming Pluripotent Stem Cell Dependence on the Repair of Endogenous DNA Damage. Stem cell reports, 6 1, 44-54

Gupta, Nishant; Wikenheiser-Brokamp, Kathryn A; Fischer, Aryeh; McCormack, Francis X 2016. Diffuse Cystic Lung Disease as the Presenting Manifestation of Sjögren Syndrome. Annals of the American Thoracic Society, 13 3, 371-5

McCormack, Francis X; Gupta, Nishant; Finlay, Geraldine R; Young, Lisa R; Taveira-DaSilva, Angelo M; Glasgow, Connie G; Steagall, Wendy K; Johnson, Simon R; Sahn, Steven A; Ryu, Jay H; Strange, Charlie; Seyama, Kuniaki; Sullivan, Eugene J; Kotloff, Robert M; Downey, Gregory P; Chapman, Jeffrey T; Han, MeiLan K; D'Armiento, Jeanine M; Inoue, Yoshikazu; Henske, Elizabeth P; Bissler, John J; Colby, Thomas V; Kinder, Brent W; Wikenheiser-Brokamp, Kathryn A; Brown, Kevin K; Cordier, Jean F; Meyer, Cristopher; Cottin, Vincent; Brozek, Jan L; Smith, Karen; Wilson, Kevin C; Moss, Joel 2016. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. American journal of respiratory and critical care medicine, 194 6, 748-61

Osterburg, Andrew R; Nelson, Rebecca L; Yaniv, Benyamin Z; Foot, Rachel; Donica, Walter R F; Nashu, Madison A; Liu, Huan; Wikenheiser-Brokamp, Kathryn A; Moss, Joel; Gupta, Nishant; McCormack, Francis X; Borchers, Michael T 2016. NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline. JCI insight, 1 16, e87270

Xu, Yan; Mizuno, Takako; Sridharan, Anusha; Du, Yina; Guo, Minzhe; Tang, Jie; Wikenheiser-Brokamp, Kathryn A; Perl, Anne-Karina T; Funari, Vincent A; Gokey, Jason J; Stripp, Barry R; Whitsett, Jeffrey A 2016. Single-cell RNA sequencing identifies diverse roles of epithelial cells in idiopathic pulmonary fibrosis. JCI insight, 1 20, e90558

Adams, A K; Hallenbeck, G E; Casper, K A; Patil, Y J; Wilson, K M; Kimple, R J; Lambert, P F; Witte, D P; Xiao, W; Gillison, M L; Wikenheiser-Brokamp, K A; Wise-Draper, T M; Wells, S I 2015. DEK promotes HPV-positive and -negative head and neck cancer cell proliferation. Oncogene, 34 7, 868-77

Akeno, N; Miller, A L; Ma, X; Wikenheiser-Brokamp, K A 2015. p53 suppresses carcinoma progression by inhibiting mTOR pathway activation. Oncogene, 34 5, 589-99

Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part II. American journal of respiratory and critical care medicine, 192 1, 17-29

Gupta, Nishant; Vassallo, Robert; Wikenheiser-Brokamp, Kathryn A; McCormack, Francis X 2015. Diffuse Cystic Lung Disease. Part I. American journal of respiratory and critical care medicine, 191 12, 1354-66

Klein, Melissa; Hershey, Gurjit K Khurana; Devarajan, Prasad; Muglia, Louis J; Wikenheiser-Brokamp, Kathryn A; Loch, Jill; Hostetter, Margaret K; Strauss, Arnold W; DeWitt, Thomas G 2015. Enhancing Pediatric Fellows' Research Training: Development of an Office of Pediatric Clinical Fellowships. The Journal of pediatrics, 167 3, 506-7.e1

Lombardi, Anne J; Hoskins, Elizabeth E; Foglesong, Grant D; Wikenheiser-Brokamp, Kathryn A; Wiesmüller, Lisa; Hanenberg, Helmut; Andreassen, Paul R; Jacobs, Allison J; Olson, Susan B; Keeble, Winifred W; Hays, Laura E; Wells, Susanne I 2015. Acquisition of Relative Interstrand Crosslinker Resistance and PARP Inhibitor Sensitivity in Fanconi Anemia Head and Neck Cancers. Clinical cancer research : an official journal of the American Association for Cancer Research, 21 8, 1962-72

Saito, Atsushi; Nikolaidis, Nikolaos M; Amlal, Hassane; Uehara, Yasuaki; Gardner, Jason C; LaSance, Kathleen; Pitstick, Lori B; Bridges, James P; Wikenheiser-Brokamp, Kathryn A; McGraw, Dennis W; Woods, Jason C; Sabbagh, Yves; Schiavi, Susan C; Altini?ik, Göksel; Jakopovi?, Marko; Inoue, Yoshikazu; McCormack, Francis X 2015. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment. Science translational medicine, 7 313, 313ra181

Wagh, Purnima K; Gardner, Margaret A; Ma, Xiaolan; Callahan, Melissa; Shannon, John M; Wert, Susan E; Messinger, Yoav H; Dehner, Louis P; Hill, D Ashley; Wikenheiser-Brokamp, Kathryn A 2015. Cell- and developmental stage-specific Dicer1 ablation in the lung epithelium models cystic pleuropulmonary blastoma. The Journal of pathology, 236 1, 41-52

Chlon, Timothy M; Hoskins, Elizabeth E; Mayhew, Christopher N; Wikenheiser-Brokamp, Kathryn A; Davies, Stella M; Mehta, Parinda; Myers, Kasiani C; Wells, James M; Wells, Susanne I 2014. High-risk human papillomavirus E6 protein promotes reprogramming of Fanconi anemia patient cells through repression of p53 but does not allow for sustained growth of induced pluripotent stem cells. Journal of virology, 88 19, 11315-26

Cundiff, William B; McCormack, Francis X; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Kotloff, Robert; Benzaquen, Sadia 2014. Successful management of a chronic, refractory bronchopleural fistula with endobronchial valves followed by talc pleurodesis. American journal of respiratory and critical care medicine, 189 4, 490-1

Dong, Zhongyun; Meller, Jaroslaw; Succop, Paul; Wang, Jiang; Wikenheiser-Brokamp, Kathryn; Starnes, Sandra; Lu, Shan 2014. Secretory phospholipase A2-IIa upregulates HER/HER2-elicited signaling in lung cancer cells. International journal of oncology, 45 3, 978-84

McCauley, Heather A; Liu, Chia-Yang; Attia, Aria C; Wikenheiser-Brokamp, Kathryn A; Zhang, Yujin; Whitsett, Jeffrey A; Guasch, Géraldine 2014. TGF? signaling inhibits goblet cell differentiation via SPDEF in conjunctival epithelium. Development (Cambridge, England), 141 23, 4628-39

Alsidawi, S; Morris, J C; Wikenheiser-Brokamp, K A; Starnes, S L; Karim, N A 2013. Mucoepidermoid carcinoma of the lung: a case report and literature review. Case reports in oncological medicine, 2013 , 625243

McCormack, Francis X; Wilmott, Clay; Young, Lisa R; Wikenheiser-Brokamp, Kathryn 2013. An atoll variant that mocks. American journal of respiratory and critical care medicine, 188 1, 110

Zafar, Muhammad A; McCormack, Francis X; Rahman, Shahid; Tencza, Christian; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Shizukuda, Yukitaka; Elwing, Jean M 2013. Pulmonary vascular shunts in exercise-intolerant patients with lymphangioleiomyomatosis. American journal of respiratory and critical care medicine, 188 9, 1167-70

Gupta, Nishant; Aragaki, Alejandro; Wikenheiser-Brokamp, Kathryn A; Benzaquen, Sadia; Panos, Ralph J 2012. Occam's razor or Hickam's dictum? Journal of bronchology & interventional pulmonology, 19 3, 216-9

Hoskins, Elizabeth E; Morreale, Richard J; Werner, Stephen P; Higginbotham, Jennifer M; Laimins, Laimonis A; Lambert, Paul F; Brown, Darron R; Gillison, Maura L; Nuovo, Gerard J; Witte, David P; Kim, Mi-Ok; Davies, Stella M; Mehta, Parinda A; Butsch Kovacic, Melinda; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The fanconi anemia pathway limits human papillomavirus replication. Journal of virology, 86 15, 8131-8

Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; Byrnes, Sue; McCormack, Francis X 2012. Utility of transbronchial biopsy in the diagnosis of lymphangioleiomyomatosis. Frontiers of medicine, 6 4, 395-405

Meraj, Riffat; Wikenheiser-Brokamp, Kathryn A; Young, Lisa R; McCormack, Francis X 2012. Lymphangioleiomyomatosis: new concepts in pathogenesis, diagnosis, and treatment. Seminars in respiratory and critical care medicine, 33 5, 486-97

Privette Vinnedge, Lisa M; Ho, Shuk-Mei; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PloS one, 7 10, e46985

Wise-Draper, Trisha M; Draper, David J; Gutkind, J Silvio; Molinolo, Alfredo A; Wikenheiser-Brokamp, Kathryn A; Wells, Susanne I 2012. Future directions and treatment strategies for head and neck squamous cell carcinomas. Translational research : the journal of laboratory and clinical medicine, 160 3, 167-77

Fuller, Kevin K; Richie, Daryl L; Feng, Xizhi; Krishnan, Karthik; Stephens, Timothy J; Wikenheiser-Brokamp, Kathryn A; Askew, David S; Rhodes, Judith C 2011. Divergent Protein Kinase A isoforms co-ordinately regulate conidial germination, carbohydrate metabolism and virulence in Aspergillus fumigatus Molecular microbiology, 79 4, 1045-62

Hagaman, Jared T; Panos, Ralph J; McCormack, Francis X; Thakar, Charuhas V; Wikenheiser-Brokamp, Kathryn A; Shipley, Ralph T; Kinder, Brent W 2011. Vitamin D deficiency and reduced lung function in connective tissue-associated interstitial lung diseases Chest, 139 2, 353-60

Kupert, Elena; Anderson, Marshall; Liu, Yin; Succop, Paul; Levin, Linda; Wang, Jiang; Wikenheiser-brokamp, Kathryn; Chen, Pingping; Pinney, Susan M; Macdonald, Trudy; Dong, Zhongyun; Starnes, Sandra; Lu, Shan 2011. Plasma secretory phospholipase A2-IIa as a potential biomarker for lung cancer in patients with solitary pulmonary nodules. BMC cancer, 11 , 513

Privette Vinnedge, L M; McClaine, R; Wagh, P K; Wikenheiser-Brokamp, K A; Waltz, S E; Wells, S I 2011. The human DEK oncogene stimulates ?-catenin signaling, invasion and mammosphere formation in breast cancer Oncogene, ,

Hill, D Ashley; Ivanovich, Jennifer; Priest, John R; Gurnett, Christina A; Dehner, Louis P; Desruisseau, David; Jarzembowski, Jason A; Wikenheiser-Brokamp, Kathryn A; Suarez, Brian K; Whelan, Alison J; Williams, Gretchen; Bracamontes, Dawn; Messinger, Yoav; Goodfellow, Paul J 2009. DICER1 mutations in familial pleuropulmonary blastoma Science (New York, N.Y.), 325 5943, 965

Simpson, David S; Mason-Richie, Nicole A; Gettler, Caitlin A; Wikenheiser-Brokamp, Kathryn A 2009. Retinoblastoma family proteins have distinct functions in pulmonary epithelial cells in vivo critical for suppressing cell growth and tumorigenesis Cancer research, 69 22, 8733-41

Wise-Draper, Trisha M; Morreale, Richard J; Morris, Teresa A; Mintz-Cole, Rachael A; Hoskins, Elizabeth E; Balsitis, Scott J; Husseinzadeh, Nader; Witte, David P; Wikenheiser-Brokamp, Kathryn A; Lambert, Paul F; Wells, Susanne I 2009. DEK proto-oncogene expression interferes with the normal epithelial differentiation program The American journal of pathology, 174 1, 71-81

Young, L.R., Franz, D.N., Nagarkatte, P., Fletcher, C.D.M., Wikenheiser-Brokamp, K.A., Galsky, M.D., Lam, A., Gelfand, M.J., McCormack, F.X. 2009. Utility of FDG-PET in lymphangioleiomyomatosis and tuberous sclerosis complex. Chest, 136 3, 962-933

Ciampi, Raffaele; Giordano, Thomas J; Wikenheiser-Brokamp, Kathryn; Koenig, Ronald J; Nikiforov, Yuri E 2007. HOOK3-RET: a novel type of RET/PTC rearrangement in papillary thyroid carcinoma. Endocrine-related cancer, 14 2, 445-52

Mayhew, Christopher N; Carter, Scott L; Fox, Sejal R; Sexton, Charlene R; Reed, Christopher A; Srinivasan, Seetha V; Liu, Xiangdong; Wikenheiser-Brokamp, Kathryn; Boivin, Gregory P; Lee, Ju-Seog; Aronow, Bruce J; Thorgeirsson, Snorri S; Knudsen, Erik S 2007. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology, 133 3, 976-84

Dehner, Louis P; Messinger, Yoav H; Schultz, Kris Ann P; Williams, Gretchen M; Wikenheiser-Brokamp, Kathryn; Hill, D Ashley . Pleuropulmonary Blastoma: Evolution of an Entity as an Entry into a Familial Tumor Predisposition Syndrome. Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society, 18 6, 504-11