Today is

Department of

Pathology and Laboratory Medicine

Photo of  Gang Huang, PhD

Gang Huang, PhD

Education/Credentials
  • Doctorate: Kyoto University
  • Postdoctoral Fellow: Beth Israel Deaconess Medical Center
  • Postdoctoral Fellow: Memorial Sloan- Kettering Cancer Center
Contact Information
  • Cincinnati Childrens Hospital Medical Center
  • 3333 Burnett Ave.
  • S7.607
  • Cincinnati, Ohio 45227
  • Office (513) 636-3214
  • Fax (513) 636-3768
  • Email Gang.Huang@cchmc.org

Peer Reviewed Publications

Kim, Jung-Hyun; Baddoo, Melody C; Park, Eun Young; Stone, Joshua K; Park, Hyeonsoo; Butler, Thomas W; Huang, Gang; Yan, Xiaomei; Pauli-Behn, Florencia; Myers, Richard M; Tan, Ming; Flemington, Erik K; Lim, Ssang-Taek; Ahn, Eun-Young Erin 2016. SON and Its Alternatively Spliced Isoforms Control MLL Complex-Mediated H3K4me3 and Transcription of Leukemia-Associated Genes. Molecular cell, 61 6, 859-73

Wu, Jianqiang; Keng, Vincent W; Patmore, Deanna M; Kendall, Jed J; Patel, Ami V; Jousma, Edwin; Jessen, Walter J; Choi, Kwangmin; Tschida, Barbara R; Silverstein, Kevin A T; Fan, Danhua; Schwartz, Eric B; Fuchs, James R; Zou, Yuanshu; Kim, Mi-Ok; Dombi, Eva; Levy, David E; Huang, Gang; Cancelas, Jose A; Stemmer-Rachamimov, Anat O; Spinner, Robert J; Largaespada, David A; Ratner, Nancy 2016. Insertional Mutagenesis Identifies a STAT3/Arid1b/?-catenin Pathway Driving Neurofibroma Initiation. Cell reports, 14 8, 1979-90

Cui, Yajuan; Tong, Hongyan; Du, Xin; Li, Bing; Gale, Robert Peter; Qin, Tiejun; Liu, Jinqin; Xu, Zefeng; Zhang, Yue; Huang, Gang; Jin, Jie; Fang, Liwei; Zhang, Hongli; Pan, Lijuan; Hu, Naibo; Qu, Shiqiang; Xiao, Zhijian 2015. Impact of TET2, SRSF2, ASXL1 and SETBP1 mutations on survival of patients with chronic myelomonocytic leukemia. Experimental hematology & oncology, 4 , 14

Kühn, Michael W M; Hadler, Michael J; Daigle, Scott R; Koche, Richard P; Krivtsov, Andrei V; Olhava, Edward J; Caligiuri, Michael A; Huang, Gang; Bradner, James E; Pollock, Roy M; Armstrong, Scott A 2015. MLL partial tandem duplication leukemia cells are sensitive to small molecule DOT1L inhibition. Haematologica, 100 5, e190-3

Park, Jino; Schlederer, Michaela; Schreiber, Martin; Ice, Ryan; Merkel, Olaf; Bilban, Martin; Hofbauer, Sebastian; Kim, Soojin; Addison, Joseph; Zou, Jie; Ji, Chunyan; Bunting, Silvia T; Wang, Zhengqi; Shoham, Menachem; Huang, Gang; Bago-Horvath, Zsuzsanna; Gibson, Laura F; Rojanasakul, Yon; Remick, Scot; Ivanov, Alexey; Pugacheva, Elena; Bunting, Kevin D; Moriggl, Richard; Kenner, Lukas; Tse, William 2015. AF1q is a novel TCF7 co-factor which activates CD44 and promotes breast cancer metastasis. Oncotarget, 6 24, 20697-710

Roychoudhury, Jayeeta; Clark, Jason P; Gracia-Maldonado, Gabriel; Unnisa, Zeenath; Wunderlich, Mark; Link, Kevin A; Dasgupta, Nupur; Aronow, Bruce; Huang, Gang; Mulloy, James C; Kumar, Ashish R 2015. MEIS1 regulates an HLF-oxidative stress axis in MLL-fusion gene leukemia. Blood, 125 16, 2544-52

Wang, Lan; Man, Na; Sun, Xiao-Jian; Tan, Yurong; Cao, Marta Garcia; Liu, Fan; Hatlen, Megan; Xu, Haiming; Huang, Gang; Mattlin, Meredith; Mehta, Arpit; Rampersaud, Evadnie; Benezra, Robert; Nimer, Stephen D 2015. Regulation of AKT signaling by Id1 controls t(8;21) leukemia initiation and progression. Blood, 126 5, 640-50

Cui, Rui; Gale, Robert Peter; Zhu, Guoqing; Xu, Zefeng; Qin, Tiejun; Zhang, Yue; Huang, Gang; Li, Bing; Fang, Liwei; Zhang, Hongli; Pan, Lijuan; Hu, Naibo; Qu, Shiqiang; Xiao, Zhijian 2014. Serum iron metabolism and erythropoiesis in patients with myelodysplastic syndrome not receiving RBC transfusions. Leukemia research, 38 5, 545-50

Li, Bing; Xu, Junqing; Li, Chengwen; Gale, Robert Peter; Xu, Zefeng; Qin, Tiejun; Zhang, Yue; Huang, Gang; Fang, Liwei; Zhang, Hongli; Pan, Lijuan; Hu, Naibo; Qu, Shiqiang; Xiao, Zhijian 2014. Cytogenetic studies and their prognostic contribution in 565 Chinese patients with primary myelofibrosis. American journal of hematology, 89 11, 1043-6

Sashida, Goro; Harada, Hironori; Matsui, Hirotaka; Oshima, Motohiko; Yui, Makiko; Harada, Yuka; Tanaka, Satomi; Mochizuki-Kashio, Makiko; Wang, Changshan; Saraya, Atsunori; Muto, Tomoya; Hayashi, Yoshihiro; Suzuki, Kotaro; Nakajima, Hiroshi; Inaba, Toshiya; Koseki, Haruhiko; Huang, Gang; Kitamura, Toshio; Iwama, Atsushi 2014. Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukaemic transformation. Nature communications, 5 , 4177

Staber, Philipp B; Zhang, Pu; Ye, Min; Welner, Robert S; Levantini, Elena; Di Ruscio, Annalisa; Ebralidze, Alexander K; Bach, Christian; Zhang, Hong; Zhang, Junyan; Vanura, Katrina; Delwel, Ruud; Yang, Henry; Huang, Gang; Tenen, Daniel G 2014. The Runx-PU.1 pathway preserves normal and AML/ETO9a leukemic stem cells. Blood, 124 15, 2391-9

Zhao, Xinghui; Chen, Aili; Yan, Xiaomei; Zhang, Yue; He, Fuhong; Hayashi, Yoshihiro; Dong, Yunzhu; Rao, Yalan; Li, Bo; Conway, Rajeana M; Maiques-Diaz, Alba; Elf, Shannon E; Huang, Nuomin; Zuber, Johannes; Xiao, Zhijian; Tse, William; Tenen, Daniel G; Wang, Qianfei; Chen, Wei; Mulloy, James C; Nimer, Stephen D; Huang, Gang 2014. Downregulation of RUNX1/CBF? by MLL fusion proteins enhances hematopoietic stem cell self-renewal. Blood, 123 11, 1729-38

Zhu, Xiaofan; He, Fuhong; Zeng, Huimin; Ling, Shaoping; Chen, Aili; Wang, Yaqin; Yan, Xiaomei; Wei, Wei; Pang, Yakun; Cheng, Hui; Hua, Chunlan; Zhang, Yue; Yang, Xuejing; Lu, Xin; Cao, Lihua; Hao, Lingtong; Dong, Lili; Zou, Wei; Wu, Jun; Li, Xia; Zheng, Si; Yan, Jin; Zhou, Jing; Zhang, Lixia; Mi, Shuangli; Wang, Xiaojuan; Zhang, Li; Zou, Yao; Chen, Yumei; Geng, Zhe; Wang, Jianmin; Zhou, Jianfeng; Liu, Xin; Wang, Jianxiang; Yuan, Weiping; Huang, Gang; Cheng, Tao; Wang, Qian-Fei 2014. Identification of functional cooperative mutations of SETD2 in human acute leukemia. Nature genetics, 46 3, 287-93

Goyama, Susumu; Schibler, Janet; Cunningham, Lea; Zhang, Yue; Rao, Yalan; Nishimoto, Nahoko; Nakagawa, Masahiro; Olsson, Andre; Wunderlich, Mark; Link, Kevin A; Mizukawa, Benjamin; Grimes, H Leighton; Kurokawa, Mineo; Liu, P Paul; Huang, Gang; Mulloy, James C 2013. Transcription factor RUNX1 promotes survival of acute myeloid leukemia cells. The Journal of clinical investigation, 123 9, 3876-88

Hirai, Hideyo; Kamio, Naoka; Huang, Gang; Matsusue, Akiko; Ogino, Shinpei; Kimura, Nobuhiko; Satake, Sakiko; Ashihara, Eishi; Imanishi, Jiro; Tenen, Daniel G; Maekawa, Taira 2013. Cyclic AMP responsive element binding proteins are involved in 'emergency' granulopoiesis through the upregulation of CCAAT/enhancer binding protein ?. PloS one, 8 1, e54862

Li, Ailing; Yang, Youyang; Gao, Chong; Lu, Jiayun; Jeong, Ha-Won; Liu, Bee H; Tang, Ping; Yao, Xiaopan; Neuberg, Donna; Huang, Gang; Tenen, Daniel G; Chai, Li 2013. A SALL4/MLL/HOXA9 pathway in murine and human myeloid leukemogenesis. The Journal of clinical investigation, 123 10, 4195-207

Schönheit, Jörg; Kuhl, Christiane; Gebhardt, Marie Luise; Klett, Francisco Fernández; Riemke, Pia; Scheller, Marina; Huang, Gang; Naumann, Ronald; Leutz, Achim; Stocking, Carol; Priller, Josef; Andrade-Navarro, Miguel A; Rosenbauer, Frank 2013. PU.1 level-directed chromatin structure remodeling at the Irf8 gene drives dendritic cell commitment. Cell reports, 3 5, 1617-28

Staber, Philipp B; Zhang, Pu; Ye, Min; Welner, Robert S; Nombela-Arrieta, César; Bach, Christian; Kerenyi, Marc; Bartholdy, Boris A; Zhang, Hong; Alberich-Jordà, Meritxell; Lee, Sanghoon; Yang, Henry; Ng, Felicia; Zhang, Junyan; Leddin, Mathias; Silberstein, Leslie E; Hoefler, Gerald; Orkin, Stuart H; Göttgens, Berthold; Rosenbauer, Frank; Huang, Gang; Tenen, Daniel G 2013. Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Molecular cell, 49 5, 934-46

Zhao, Xinghui; Zhao, Zhanzhong; Guo, Junwei; Huang, Peitang; Zhu, Xudong; Zhou, Xiaowei; Yang, Zhixin; Zhao, Lixia; Xu, Long; Xu, Junjie; Fu, Ling; Zhang, Jun; Zhang, Xiaopeng; Dong, Yunzhu; Huang, Gang; Wang, Qianfei; Li, Bo; Song, Xiaohong; Yang, Xiuxu; Liu, Shuling; Yi, Shaoqiong; Yu, Ting; Yu, Changming; Hou, Lihua; Li, Jianmin; Chen, Wei 2013. Creation of a six-fingered artificial transcription factor that represses the hepatitis B virus HBx gene integrated into a human hepatocellular carcinoma cell line. Journal of biomolecular screening, 18 4, 378-87

Zhang, Yue; Yan, Xiaomei; Sashida, Goro; Zhao, Xinghui; Rao, Yalan; Goyama, Susumu; Whitman, Susan P; Zorko, Nicholas; Bernot, Kelsie; Conway, Rajeana M; Witte, David; Wang, Qian-Fei; Tenen, Daniel G; Xiao, Zhijian; Marcucci, Guido; Mulloy, James C; Grimes, H Leighton; Caligiuri, Michael A; Huang, Gang 2012. Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells. Blood, 120 5, 1118-29

Zorko, Nicholas A; Bernot, Kelsie M; Whitman, Susan P; Siebenaler, Ronald F; Ahmed, Elshafa H; Marcucci, Gabriele G; Yanes, Daniel A; McConnell, Kathleen K; Mao, Charlene; Kalu, Chidimma; Zhang, Xiaoli; Jarjoura, David; Dorrance, Adrienne M; Heerema, Nyla A; Lee, Benjamin H; Huang, Gang; Marcucci, Guido; Caligiuri, Michael A 2012. Mll partial tandem duplication and Flt3 internal tandem duplication in a double knock-in mouse recapitulates features of counterpart human acute myeloid leukemias. Blood, 120 5, 1130-6

Huang, Gang; Zhao, Xinghui; Wang, Lan; Elf, Shannon; Xu, Hao; Zhao, Xinyang; Sashida, Goro; Zhang, Yue; Liu, Yan; Lee, Jennifer; Menendez, Silvia; Yang, Youyang; Yan, Xiaomei; Zhang, Pu; Tenen, Daniel G; Osato, Motomi; Hsieh, James J-D; Nimer, Stephen D 2011. The ability of MLL to bind RUNX1 and methylate H3K4 at PU.1 regulatory regions is impaired by MDS/AML-associated RUNX1/AML1 mutations. Blood, 118 25, 6544-52

Sashida, Goro; Bae, Narae; Di Giandomenico, Silvana; Asai, Takashi; Gurvich, Nadia; Bazzoli, Elena; Liu, Yan; Huang, Gang; Zhao, Xinyang; Menendez, Silvia; Nimer, Stephen D 2011. The mef/elf4 transcription factor fine tunes the DNA damage response. Cancer research, 71 14, 4857-65

Wang, Lan; Gural, Alexander; Sun, Xiao-Jian; Zhao, Xinyang; Perna, Fabiana; Huang, Gang; Hatlen, Megan A; Vu, Ly; Liu, Fan; Xu, Haiming; Asai, Takashi; Xu, Hao; Deblasio, Tony; Menendez, Silvia; Voza, Francesca; Jiang, Yanwen; Cole, Philip A; Zhang, Jinsong; Melnick, Ari; Roeder, Robert G; Nimer, Stephen D 2011. The leukemogenicity of AML1-ETO is dependent on site-specific lysine acetylation. Science (New York, N.Y.), 333 6043, 765-9

Xiong, Yin; Li, Zejuan; Ji, Min; Tan, Aik-Choon; Bemis, Judson; Tse, Jove-Victor; Huang, Gang; Park, Jino; Ji, Chunyan; Chen, Jianjun; Bemis, Lynne T; Bunting, Kevin D; Tse, William 2011. MIR29B regulates expression of MLLT11 (AF1Q), an MLL fusion partner, and low MIR29B expression associates with adverse cytogenetics and poor overall survival in AML. British journal of haematology, 153 6, 753-7

Kamikubo, Yasuhiko; Zhao, Ling; Wunderlich, Mark; Corpora, Takeshi; Hyde, R Katherine; Paul, Thomas A; Kundu, Mondira; Garrett, Lisa; Compton, Sheila; Huang, Gang; Wolff, Linda; Ito, Yoshiaki; Bushweller, John; Mulloy, James C; Liu, P Paul 2010. Accelerated leukemogenesis by truncated CBF beta-SMMHC defective in high-affinity binding with RUNX1. Cancer cell, 17 5, 455-68

O'Brien, Karen B; Alberich-Jordà, Meritxell; Yadav, Neelu; Kocher, Olivier; Diruscio, Annalisa; Ebralidze, Alexander; Levantini, Elena; Sng, Natasha J L; Bhasin, Manoj; Caron, Tyler; Kim, Daehoon; Steidl, Ulrich; Huang, Gang; Halmos, Balázs; Rodig, Scott J; Bedford, Mark T; Tenen, Daniel G; Kobayashi, Susumu 2010. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development (Cambridge, England), 137 13, 2147-56

Liu, Yan; Elf, Shannon E; Miyata, Yasuhiko; Sashida, Goro; Liu, Yuhui; Huang, Gang; Di Giandomenico, Silvana; Lee, Jennifer M; Deblasio, Anthony; Menendez, Silvia; Antipin, Jack; Reva, Boris; Koff, Andrew; Nimer, Stephen D 2009. p53 regulates hematopoietic stem cell quiescence. Cell stem cell, 4 1, 37-48