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Department of

Pathology and Laboratory Medicine

Photo of  Mohammad Azam, PhD

Mohammad Azam, PhD

Assistant Professor

Education/Credentials
  • Doctorate: JNU, New Delhi, India
  • Postdoctoral Fellow: Massachusetts Institute of Technology
  • Postdoctoral Fellow: Children’s Hospital of Boston
Contact Information
  • Cincinnati Childrens Hospital Medical Center
  • 3333 Burnet Avenue, ML 7013
  • Cincinnati, Ohio 45229
  • Office (513) 803-1413
  • Email mohammad.azam@cchmc.org

Peer Reviewed Publications

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Evelyn, Chris R; Biesiada, Jacek; Rance, Mark; Thapa, Mahendra B; Shah, Neil P; Meller, Jarek; Zheng, Yi; Azam, Mohammad 2015. Targeting substrate-site in Jak2 kinase prevents emergence of genetic resistance. Scientific reports, 5 , 14538

Kesarwani, Meenu; Huber, Erika; Kincaid, Zachary; Azam, Mohammad 2014. A method for screening and validation of resistant mutations against kinase inhibitors. Journal of visualized experiments : JoVE, 94,

Kamthan, Ayushi; Kamthan, Mohan; Azam, Mohammad; Chakraborty, Niranjan; Chakraborty, Subhra; Datta, Asis 2012. Expression of a fungal sterol desaturase improves tomato drought tolerance, pathogen resistance and nutritional quality. Scientific reports, 2 , 951

Azam, Mohammad; Powers, John T; Einhorn, William; Huang, Wei-Sheng; Shakespeare, William C; Zhu, Xiaotian; Dalgarno, David; Clackson, Tim; Sawyer, Tomi K; Daley, George Q 2010. AP24163 inhibits the gatekeeper mutant of BCR-ABL and suppresses in vitro resistance. Chemical biology & drug design, 75 2, 223-7

Zhang, Jianming; Adrián, Francisco J; Jahnke, Wolfgang; Cowan-Jacob, Sandra W; Li, Allen G; Iacob, Roxana E; Sim, Taebo; Powers, John; Dierks, Christine; Sun, Fangxian; Guo, Gui-Rong; Ding, Qiang; Okram, Barun; Choi, Yongmun; Wojciechowski, Amy; Deng, Xianming; Liu, Guoxun; Fendrich, Gabriele; Strauss, André; Vajpai, Navratna; Grzesiek, Stephan; Tuntland, Tove; Liu, Yi; Bursulaya, Badry; Azam, Mohammad; Manley, Paul W; Engen, John R; Daley, George Q; Warmuth, Markus; Gray, Nathanael S 2010. Targeting Bcr-Abl by combining allosteric with ATP-binding-site inhibitors. Nature, 463 7280, 501-6

Huang, Wei-Sheng; Zhu, Xiaotian; Wang, Yihan; Azam, Mohammad; Wen, David; Sundaramoorthi, Raji; Thomas, R Mathew; Liu, Shuangying; Banda, Geetha; Lentini, Scott P; Das, Sasmita; Xu, Qihong; Keats, Jeff; Wang, Frank; Wardwell, Scott; Ning, Yaoyu; Snodgrass, Joseph T; Broudy, Marc I; Russian, Karin; Daley, George Q; Iuliucci, John; Dalgarno, David C; Clackson, Tim; Sawyer, Tomi K; Shakespeare, William C 2009. 9-(Arenethenyl)purines as dual Src/Abl kinase inhibitors targeting the inactive conformation: design, synthesis, and biological evaluation. Journal of medicinal chemistry, 52 15, 4743-56

Nardi, Valentina; Naveiras, Olaia; Azam, Mohammad; Daley, George Q 2009. ICSBP-mediated immune protection against BCR-ABL-induced leukemia requires the CCL6 and CCL9 chemokines. Blood, 113 16, 3813-20

Viswanathan, Srinivas R; Powers, John T; Einhorn, William; Hoshida, Yujin; Ng, Tony L; Toffanin, Sara; O'Sullivan, Maureen; Lu, Jun; Phillips, Letha A; Lockhart, Victoria L; Shah, Samar P; Tanwar, Pradeep S; Mermel, Craig H; Beroukhim, Rameen; Azam, Mohammad; Teixeira, Jose; Meyerson, Matthew; Hughes, Timothy P; Llovet, Josep M; Radich, Jerald; Mullighan, Charles G; Golub, Todd R; Sorensen, Poul H; Daley, George Q 2009. Lin28 promotes transformation and is associated with advanced human malignancies. Nature genetics, 41 7, 843-8

Azam, Mohammad; Seeliger, Markus A; Gray, Nathanael S; Kuriyan, John; Daley, George Q 2008. Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nature structural & molecular biology, 15 10, 1109-18

Raz, Tal; Nardi, Valentina; Azam, Mohammad; Cortes, Jorge; Daley, George Q 2007. Farnesyl transferase inhibitor resistance probed by target mutagenesis. Blood, 110 6, 2102-9

Azam, Mohammad; Nardi, Valentina; Shakespeare, William C; Metcalf, Chester A; Bohacek, Regine S; Wang, Yihan; Sundaramoorthi, Raji; Sliz, Piotr; Veach, Darren R; Bornmann, William G; Clarkson, Bayard; Dalgarno, David C; Sawyer, Tomi K; Daley, George Q 2006. Activity of dual SRC-ABL inhibitors highlights the role of BCR/ABL kinase dynamics in drug resistance. Proceedings of the National Academy of Sciences of the United States of America, 103 24, 9244-9

Weisberg, Ellen; Manley, Paul W; Breitenstein, Werner; Brüggen, Josef; Cowan-Jacob, Sandra W; Ray, Arghya; Huntly, Brian; Fabbro, Doriano; Fendrich, Gabriele; Hall-Meyers, Elizabeth; Kung, Andrew L; Mestan, Jürgen; Daley, George Q; Callahan, Linda; Catley, Laurie; Cavazza, Cara; Azam, Mohammad; Mohammed, Azam; Neuberg, Donna; Wright, Renee D; Gilliland, D Gary; Griffin, James D 2005. Characterization of AMN107, a selective inhibitor of native and mutant Bcr-Abl. Cancer cell, 7 2, 129-41

Nardi, Valentina; Azam, Mohammad; Daley, George Q 2004. Mechanisms and implications of imatinib resistance mutations in BCR-ABL. Current opinion in hematology, 11 1, 35-43

Azam, Mohammad; Latek, Robert R; Daley, George Q 2003. Mechanisms of autoinhibition and STI-571/imatinib resistance revealed by mutagenesis of BCR-ABL. Cell, 112 6, 831-43

Azam, Mohammad; Raz, Tal; Nardi, Valentina; Opitz, Sarah L.; Daley, George Q. 2003. A screen to identify drug resistant variants to target-directed anti-cancer agents. Biological procedures online, 5 , 204-210

Azam, Mohammad; Kesarwani, Meenu; Chakraborty, Subhra; Natarajan, Krishnamurthy; Datta, Asis 2002. Cloning and characterization of the 5'-flanking region of the oxalate decarboxylase gene from Flammulina velutipes. The Biochemical journal, 367 Pt 1, 67-75

Khanna, Richie; Chang, Seon H; Andrabi, Shaida; Azam, Mohammad; Kim, Anthony; Rivera, Alicia; Brugnara, Carlo; Low, Philip S; Liu, Shih-Chun; Chishti, Athar H 2002. Headpiece domain of dematin is required for the stability of the erythrocyte membrane. Proceedings of the National Academy of Sciences of the United States of America, 99 10, 6637-42