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Pathobiology & Molecular Medicine

Photo of  Nives Zimmermann, M.D.

Nives Zimmermann, M.D.

Clinical Interest

Pathology

Research Interests

The research in the Zimmermann lab concentrates on eosinophilic diseases, which include allergic diseases such as asthma, as well as parasitic infestation, eosinophilic gastrointestinal diseases and rare eosinophilic leukemias. Eosinophils can be present in some tissues with no ill effects, while at other times or in other tissues they cause serious damage. My lab's goal is to learn the mechanisms that cause this damage. Currently, we are focused on understanding the molecular mechanism of eosinophil survival and death that lead to this damage. One thing in common of all situations with hypereosinophilia is that they cause heart damage, which tends to be the main cause of morbidity and mortality in patients. Thus, we have a model of eosinophilic heart disease in which we are studying the mechanisms of eosinophil-induced damage. We use a spectrum of approaches, from in vitro cell biology and immunology, mouse modeling to patient-centered studies.

Specialties

Hematopathology
Pathology-Anatomic and Clinical

Education/Credentials
  • Medical Degree: University of Zagreb
Board Certifications & Licenses
  • American Board of Pathology (Anatomic and Clinical Pathology) 06/21/2018
  • American Board of Pathology (Hematology) 09/20/2019
Languages
    Croatian
Contact Information
  • Cardiovascular Research Center
  • 231 Albert Sabin Way
  • CVC room 0529
  • Cincinnati, Ohio 45267-0529
  • Office 5135580135
  • Fax (513) 584-3892
  • Email nives.zimmermann@uc.edu

Peer Reviewed Publications

O'Shea, Kelly M; Rochman, Mark; Shoda, Tetsuo; Zimmermann, Nives; Caldwell, Julie; Rothenberg, Marc E 2020. Eosinophilic esophagitis with extremely high esophageal eosinophil counts. The Journal of allergy and clinical immunology, ,

Zimmermann, Nives; Nassiri, Mehdi; Zhou, Jiehao; Miller, Adam M; Zhang, Shanxiang 2020. Myeloid neoplasm with a novel cryptic PDGFRB rearrangement detected by next-generation sequencing. Cancer genetics, 244 , 55-59

Criss, Benjamin E; Zimmermann, Nives; Butler, Randall T 2019. Previously Unreported Complication of Coronary Artery Bypass Grafting: Suture Rupture Resulting in Patient's Death. Journal of forensic sciences, 64 1, 281-283

Legrand, Fanny; Cao, Yun; Wechsler, Joshua B; Zhu, Xiang; Zimmermann, Nives; Rampertaap, Shakuntala; Monsale, Joseph; Romito, Kimberly; Youngblood, Bradford A; Brock, Emily C; Makiya, Michelle A; Tomasevic, Nenad; Bebbington, Christopher; Maric, Irina; Metcalfe, Dean D; Bochner, Bruce S; Klion, Amy D 2019. Sialic acid-binding immunoglobulin-like lectin (Siglec) 8 in patients with eosinophilic disorders: Receptor expression and targeting using chimeric antibodies. The Journal of allergy and clinical immunology, 143 6, 2227-2237.e10

Prows, Daniel R; Klingler, Andrea; Gibbons, William J; Homan, Shelli M; Zimmermann, Nives 2019. Characterization of a mouse model of hypereosinophilia-associated heart disease. American journal of physiology. Heart and circulatory physiology, 317 2, H405-H414

Zimmermann, Nives; Gibbons, William J; Homan, Shelli M; Prows, Daniel R 2019. Heart disease in a mutant mouse model of spontaneous eosinophilic myocarditis maps to three loci. BMC genomics, 20 1, 727

Shoda, Tetsuo; Wen, Ting; Aceves, Seema S; Abonia, J Pablo; Atkins, Dan; Bonis, Peter A; Caldwell, Julie M; Capocelli, Kelley E; Carpenter, Christina L; Collins, Margaret H; Dellon, Evan S; Eby, Michael D; Gonsalves, Nirmala; Gupta, Sandeep K; Falk, Gary W; Hirano, Ikuo; Menard-Katcher, Paul; Kuhl, Jonathan T; Krischer, Jeffrey P; Leung, John; Mukkada, Vincent A; Spergel, Jonathan M; Trimarchi, Michael P; Yang, Guang-Yu; Zimmermann, Nives; Furuta, Glenn T; Rothenberg, Marc E 2018. Eosinophilic oesophagitis endotype classification by molecular, clinical, and histopathological analyses: a cross-sectional study. The lancet. Gastroenterology & hepatology, 3 7, 477-488

Zimmermann, Nives; Wikenheiser-Brokamp, Kathryn A 2018. Hypereosinophilic syndrome in the differential diagnosis of pulmonary infiltrates with eosinophilia. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, 121 2, 179-185

Kano, Gen; Bochner, Bruce S; Zimmermann, Nives 2017. Regulation of Siglec-8-induced intracellular reactive oxygen species production and eosinophil cell death by Src family kinases. Immunobiology, 222 2, 343-349

Zimmermann, Nives; Stanek, Jerzy 2017. Perinatal Case of Fatal Simpson-Golabi-Behmel Syndrome with Hyperplasia of Seminiferous Tubules. The American journal of case reports, 18 , 649-655

Zhu, Xiang; Hogan, Simon Patrick; Molkentin, Jeffery D; Zimmermann, Nives 2016. Cyclophilin D Regulates Necrosis But Not Apoptosis of Murine Eosinophils. American journal of physiology. Gastrointestinal and liver physiology, , ajpgi.00389.2015

Bochner, Bruce S; Zimmermann, Nives 2015. Role of siglecs and related glycan-binding proteins in immune responses and immunoregulation. The Journal of allergy and clinical immunology, 135 3, 598-608

Zimmermann, Nives; Hagen, Matthew C; Schrager, Jason J; Hebbeler-Clark, Renee S; Masineni, Sreeharsha 2015. Utility of frozen section analysis for fungal organisms in soft tissue wound debridement margin determination. Diagnostic pathology, 10 , 188

Zimmermann, Nives; Rothenberg, Marc E 2015. Mechanism of enhanced eosinophil survival in inflammation. Blood, 125 25, 3831-2

Wen, Ting; Mingler, Melissa K; Wahl, Benjamin; Khorki, M Eyad; Pabst, Oliver; Zimmermann, Nives; Rothenberg, Marc E 2014. Carbonic anhydrase IV is expressed on IL-5-activated murine eosinophils. Journal of immunology (Baltimore, Md. : 1950), 192 12, 5481-9

Zhu, Xiang; Mose, Eucabeth; Hogan, Simon P; Zimmermann, Nives 2014. Differential eosinophil and mast cell regulation: mast cell viability and accumulation in inflammatory tissue are independent of proton-sensing receptor GPR65. American journal of physiology. Gastrointestinal and liver physiology, 306 11, G974-82

Collison, Adam; Hatchwell, Luke; Verrills, Nicole; Wark, Peter A B; de Siqueira, Ana Pereira; Tooze, Melinda; Carpenter, Helen; Don, Anthony S; Morris, Jonathan C; Zimmermann, Nives; Bartlett, Nathan W; Rothenberg, Marc E; Johnston, Sebastian L; Foster, Paul S; Mattes, Joerg 2013. The E3 ubiquitin ligase midline 1 promotes allergen and rhinovirus-induced asthma by inhibiting protein phosphatase 2A activity. Nature medicine, 19 2, 232-7

Epstein, Tolly G; Kesavalu, Banurekha; Bernstein, Cheryl K; Ryan, Patrick H; Bernstein, Jonathan A; Zimmermann, Nives; Lummus, Zana; Villareal, Manuel S; Smith, Andrew M; Lenz, Peter H; Bernstein, David I 2013. Chronic traffic pollution exposure is associated with eosinophilic, but not neutrophilic inflammation in older adult asthmatics. The Journal of asthma : official journal of the Association for the Care of Asthma, 50 9, 983-9

Kano, Gen; Almanan, Maha; Bochner, Bruce S; Zimmermann, Nives 2013. Mechanism of Siglec-8-mediated cell death in IL-5-activated eosinophils: role for reactive oxygen species-enhanced MEK/ERK activation. The Journal of allergy and clinical immunology, 132 2, 437-45

Mao, Hui; Kano, Gen; Hudson, Sherry A; Brummet, Mary; Zimmermann, Nives; Zhu, Zhou; Bochner, Bruce S 2013. Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen. PloS one, 8 6, e68143

Zhu, Xiang; Mose, Eucabeth; Zimmermann, Nives 2013. Proton channel HVCN1 is required for effector functions of mouse eosinophils. BMC immunology, 14 , 24

Arumugam, Muthuvel; Ahrens, Richard; Osterfeld, Heather; Kottyan, Leah C; Shang, Xun; Maclennan, John A; Zimmermann, Nives; Zheng, Yi; Finkelman, Fred D; Hogan, Simon P 2011. Increased susceptibility of 129SvEvBrd mice to IgE-Mast cell mediated anaphylaxis. BMC immunology, 12 , 14

Lacy, Paige; Willetts, Lian; Kim, John D; Lo, Andrea N; Lam, Bon; Maclean, Emily I; Moqbel, Redwan; Rothenberg, Marc E; Zimmermann, Nives 2011. Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2. International archives of allergy and immunology, 156 2, 137-47

Gao, Pei-Song; Shimizu, Kenichi; Grant, Audrey V; Rafaels, Nicholas; Zhou, Lin-Fu; Hudson, Sherry A; Konno, Satoshi; Zimmermann, Nives; Araujo, Maria I; Ponte, Eduardo V; Cruz, Alvaro A; Nishimura, Masaharu; Su, Song-Nan; Hizawa, Nobuyuki; Beaty, Terry H; Mathias, Rasika A; Rothenberg, Marc E; Barnes, Kathleen C; Bochner, Bruce S 2010. Polymorphisms in the sialic acid-binding immunoglobulin-like lectin-8 (Siglec-8) gene are associated with susceptibility to asthma. European journal of human genetics : EJHG, 18 6, 713-9

Herbert, De'Broski R; Orekov, Tatyana; Roloson, Amanda; Ilies, Monica; Perkins, Charles; O'Brien, William; Cederbaum, Stephen; Christianson, David W; Zimmermann, Nives; Rothenberg, Marc E; Finkelman, Fred D 2010. Arginase I suppresses IL-12/IL-23p40-driven intestinal inflammation during acute schistosomiasis. Journal of immunology (Baltimore, Md. : 1950), 184 11, 6438-46

Niese, Kathryn A; Chiaramonte, Monica G; Ellies, Lesley G; Rothenberg, Marc E; Zimmermann, Nives 2010. The cationic amino acid transporter 2 is induced in inflammatory lung models and regulates lung fibrosis. Respiratory research, 11 , 87

Kottyan, Leah C; Collier, Ann R; Cao, Khanh H; Niese, Kathryn A; Hedgebeth, Megan; Radu, Caius G; Witte, Owen N; Khurana Hershey, Gurjit K; Rothenberg, Marc E; Zimmermann, Nives 2009. Eosinophil viability is increased by acidic pH in a cAMP- and GPR65-dependent manner. Blood, 114 13, 2774-82

Niese, Kathryn A; Collier, Ann R; Hajek, Amanda R; Cederbaum, Stephen D; O'Brien, William E; Wills-Karp, Marsha; Rothenberg, Marc E; Zimmermann, Nives 2009. Bone marrow cell derived arginase I is the major source of allergen-induced lung arginase but is not required for airway hyperresponsiveness, remodeling and lung inflammatory responses in mice. BMC immunology, 10 , 33

Bergeron, Céline; Boulet, Louis-Philippe; Page, Nathalie; Laviolette, Michel; Zimmermann, Nives; Rothenberg, Marc E; Hamid, Qutayba 2007. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. The Journal of allergy and clinical immunology, 119 2, 391-7

Rothenberg, Marc E; Doepker, Matthew P; Lewkowich, Ian P; Chiaramonte, Monica G; Stringer, Keith F; Finkelman, Fred D; MacLeod, Carol L; Ellies, Lesley G; Zimmermann, Nives 2006. Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proceedings of the National Academy of Sciences of the United States of America, 103 40, 14895-900

Zimmermann, Nives; Rothenberg, Marc E 2006. The arginine-arginase balance in asthma and lung inflammation. European journal of pharmacology, 533 1-3, 253-62

Fulkerson, Patricia C; Zhu, Hongyan; Williams, David A; Zimmermann, Nives; Rothenberg, Marc E 2005. CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. Blood, 106 2, 436-43

Pope, Samuel M; Fulkerson, Patricia C; Blanchard, Carine; Akei, Hiroko Saito; Nikolaidis, Nikolaos M; Zimmermann, Nives; Molkentin, Jeffery D; Rothenberg, Marc E 2005. Identification of a cooperative mechanism involving interleukin-13 and eotaxin-2 in experimental allergic lung inflammation. The Journal of biological chemistry, 280 14, 13952-61

Pope, Samuel M; Zimmermann, Nives; Stringer, Keith F; Karow, Margaret L; Rothenberg, Marc E 2005. The eotaxin chemokines and CCR3 are fundamental regulators of allergen-induced pulmonary eosinophilia. Journal of immunology (Baltimore, Md. : 1950), 175 8, 5341-50

Zimmermann, Nives; Colyer, Jessica L; Koch, Laura E; Rothenberg, Marc E 2005. Analysis of the CCR3 promoter reveals a regulatory region in exon 1 that binds GATA-1. BMC immunology, 6 , 7

Zimmermann, Nives; Doepker, Matthew P; Witte, David P; Stringer, Keith F; Fulkerson, Patricia C; Pope, Samuel M; Brandt, Eric B; Mishra, Anil; King, Nina E; Nikolaidis, Nikolaos M; Wills-Karp, Marsha; Finkelman, Fred D; Rothenberg, Marc E 2005. Expression and regulation of small proline-rich protein 2 in allergic inflammation. American journal of respiratory cell and molecular biology, 32 5, 428-35

Fulkerson, Patricia C; Zimmermann, Nives; Brandt, Eric B; Muntel, Emily E; Doepker, Matthew P; Kavanaugh, Jessica L; Mishra, Anil; Witte, David P; Zhang, Hongwei; Farber, Joshua M; Yang, Ming; Foster, Paul S; Rothenberg, Marc E 2004. Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-gamma (Mig, CXCL9). Proceedings of the National Academy of Sciences of the United States of America, 101 7, 1987-92

Fulkerson, Patricia C; Zimmermann, Nives; Hassman, Lynn M; Finkelman, Fred D; Rothenberg, Marc E 2004. Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma. Journal of immunology (Baltimore, Md. : 1950), 173 12, 7565-74

King, Nina E; Rothenberg, Marc E; Zimmermann, Nives 2004. Arginine in asthma and lung inflammation. The Journal of nutrition, 134 10 Suppl, 2830S-2836S; discuss

King, Nina E; Zimmermann, Nives; Pope, Samuel M; Fulkerson, Patricia C; Nikolaidis, Nikolaos M; Mishra, Anil; Witte, David P; Rothenberg, Marc E 2004. Expression and regulation of a disintegrin and metalloproteinase (ADAM) 8 in experimental asthma. American journal of respiratory cell and molecular biology, 31 3, 257-65

Zimmermann, Nives; Mishra, Anil; King, Nina E; Fulkerson, Patricia C; Doepker, Matthew P; Nikolaidis, Nikolaos M; Kindinger, Laura E; Moulton, Elizabeth A; Aronow, Bruce J; Rothenberg, Marc E 2004. Transcript signatures in experimental asthma: identification of STAT6-dependent and -independent pathways. Journal of immunology (Baltimore, Md. : 1950), 172 3, 1815-24

Aizawa, Hideyuki; Zimmermann, Nives; Carrigan, Patricia E; Lee, James J; Rothenberg, Marc E; Bochner, Bruce S 2003. Molecular analysis of human Siglec-8 orthologs relevant to mouse eosinophils: identification of mouse orthologs of Siglec-5 (mSiglec-F) and Siglec-10 (mSiglec-G). Genomics, 82 5, 521-30

Brandt, Eric B; Strait, Richard T; Hershko, Dan; Wang, Quan; Muntel, Emily E; Scribner, Troy A; Zimmermann, Nives; Finkelman, Fred D; Rothenberg, Marc E 2003. Mast cells are required for experimental oral allergen-induced diarrhea. The Journal of clinical investigation, 112 11, 1666-77

Nikolaidis, Nikolaos M; Zimmermann, Nives; King, Nina E; Mishra, Anil; Pope, Samuel M; Finkelman, Fred D; Rothenberg, Marc E 2003. Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung. American journal of respiratory cell and molecular biology, 29 4, 458-64

Yang, Ming; Hogan, Simon P; Mahalingam, Surendran; Pope, Sam M; Zimmermann, Nives; Fulkerson, Patricia; Dent, Lindsay A; Young, Ian G; Matthaei, Klaus I; Rothenberg, Marc E; Foster, Paul S 2003. Eotaxin-2 and IL-5 cooperate in the lung to regulate IL-13 production and airway eosinophilia and hyperreactivity. The Journal of allergy and clinical immunology, 112 5, 935-43

Zimmermann, Nives; Hershey, Gurjit Khurana; Foster, Paul S; Rothenberg, Marc E 2003. Chemokines in asthma: cooperative interaction between chemokines and IL-13. The Journal of allergy and clinical immunology, 111 2, 227-42; quiz 243

Zimmermann, Nives; King, Nina E; Laporte, Johanne; Yang, Ming; Mishra, Anil; Pope, Sam M; Muntel, Emily E; Witte, David P; Pegg, Anthony A; Foster, Paul S; Hamid, Qutayba; Rothenberg, Marc E 2003. Dissection of experimental asthma with DNA microarray analysis identifies arginase in asthma pathogenesis. The Journal of clinical investigation, 111 12, 1863-74

Zimmermann, Nives; Rothenberg, Marc E 2003. Receptor internalization is required for eotaxin-induced responses in human eosinophils. The Journal of allergy and clinical immunology, 111 1, 97-105