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Pathobiology & Molecular Medicine

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Peer Reviewed Publications

Jiange Qiu, Qianqian Li, Katherine A. Bell, Xue Yao, Erik Zhang, Jane J. Yu, Zhi Shi, and Jianxiong Jiang 2019. Small-molecule inhibition of prostaglandin receptor EP2 impairs cyclooxygenase-associated malignant glioma growth British Journal of Pharmacology , ,

Matthildi Valianou, Natalia Filippidou, Daniel L. Johnson, Peter Vogel, Erik Y. Zhang, Xiaolei Liu, Yiyang Lu, Jane J. Yu, John J. Bissler, Aristotelis Astrinidis. 2019. Rapalog resistance is associated with mesenchymal-type changes in Tsc2-null cells Sci Reports, ,

Qun Gao; Shumin Wang; Xinfeng Chen; Shaoyan Cheng; Zhen Zhang; Feng Li; Lan Huang; Yang Yang; Bin Zhou; Dongli Yue; Dan Wang; Ling Cao; Nomathamsanqa Resegofetse Maimela; Bin Zhang; Jane Yu; Liping Wang; Yi Zhang. 2019. Cancer-cell-secreted CXCL11 promoted CD8+ T cells infiltration through docetaxel-induced-release of HMGB1 in NSCLC J ImmunoTherapy of Cancer, ,

Xiaolei Liu , Erik Zhang , Kopras Elizabeth J. , Eric Smith , Yiyang Lu , Aristoteli Astreinidis , Yuet-Kin Leung , Shuk-Mei Ho , Maciej Markiewski , MAGDALENA KARBOWNICZEK , Manoocher Soleimani , Chenggang Li, and Jane J. YU 2019. mTORC1 and estrogen cooperate to induce pyruvate kinase M2 phosphorylation and increase the survival of TSC2-deficient cells Oncogenesis, ,

Hsieh, Hui-Ju; Zhang, Wei; Lin, Shu-Hong; Yang, Wen-Hao; Wang, Jun-Zhong; Shen, Jianfeng; Zhang, Yiran; Lu, Yiling; Wang, Hua; Yu, Jane; Mills, Gordon B; Peng, Guang 2018. Systems biology approach reveals a link between mTORC1 and G2/M DNA damage checkpoint recovery. Nature communications, 9 1, 3982

Li, Lifeng; Wang, Liping; Li, Jieyao; Fan, Zhirui; Yang, Li; Zhang, Zhen; Zhang, Chaoqi; Yue, Dongli; Qin, Guohui; Zhang, Tengfei; Li, Feng; Chen, Xinfeng; Ping, Yu; Wang, Dan; Gao, Qun; He, Qianyi; Huang, Lan; Li, Hong; Huang, Jianmin; Zhao, Xuan; Xue, Wenhua; Sun, Zhi; Lu, Jingli; Yu, Jane J; Zhao, Jie; Zhang, Bin; Zhang, Yi 2018. Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer. Cancer research, 78 7, 1779-1791

Qiao, Y; Zhang, C; Li, A; Wang, D; Luo, Z; Ping, Y; Zhou, B; Liu, S; Li, H; Yue, D; Zhang, Z; Chen, X; Shen, Z; Lian, J; Li, Y; Wang, S; Li, F; Huang, L; Wang, L; Zhang, B; Yu, J; Qin, Z; Zhang, Y 2018. IL6 derived from cancer-associated fibroblasts promotes chemoresistance via CXCR7 in esophageal squamous cell carcinoma. Oncogene, 37 7, 873-883

Shao, Yaping; Ye, Guozhu; Ren, Shancheng; Piao, Hai-Long; Zhao, Xinjie; Lu, Xin; Wang, Fubo; Ma, Wang; Li, Jia; Yin, Peiyuan; Xia, Tian; Xu, Chuanliang; Yu, Jane J; Sun, Yinghao; Xu, Guowang 2018. Metabolomics and transcriptomics profiles reveal the dysregulation of the tricarboxylic acid cycle and related mechanisms in prostate cancer. International journal of cancer, 143 2, 396-407

Tang, Ling; Zeng, Jun; Geng, Pengyu; Fang, Chengnan; Wang, Yang; Sun, Mingju; Wang, Changsong; Wang, Jiao; Yin, Peiyuan; Hu, Chunxiu; Guo, Lei; Yu, Jane; Gao, Peng; Li, Enyou; Zhuang, Zhengping; Xu, Guowang; Liu, Yang 2018. Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research, 24 2, 474-485

Wang Ma, Shuangyuan Wang, Tengfei Zhang, Erik Y. Zhang, Lina Zhou, Chunxiu Hu, Jane J. Yu* and Guowang Xu* 2018. Activation of choline kinase drives aberrant choline metabolism in esophageal squamous cell carcinomas. J Pharm Biomedical Anal, 155 , 148

Lam, Hilaire C; Baglini, Christian V; Lope, Alicia Llorente; Parkhitko, Andrey A; Liu, Heng-Jia; Alesi, Nicola; Malinowska, Izabela A; Ebrahimi-Fakhari, Darius; Saffari, Afshin; Yu, Jane J; Pereira, Ana; Khabibullin, Damir; Ogorek, Barbara; Nijmeh, Julie; Kavanagh, Taylor; Handen, Adam; Chan, Stephen Y; Asara, John M; Oldham, William M; Diaz-Meco, Maria T; Moscat, Jorge; Sahin, Mustafa; Priolo, Carmen; Henske, Elizabeth P 2017. p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis. Cancer research, 77 12, 3255-3267

Lee, Gina; Zheng, Yuxiang; Cho, Sungyun; Jang, Cholsoon; England, Christina; Dempsey, Jamie M; Yu, Yonghao; Liu, Xiaolei; He, Long; Cavaliere, Paola M; Chavez, Andre; Zhang, Erik; Isik, Meltem; Couvillon, Anthony; Dephoure, Noah E; Blackwell, T Keith; Yu, Jane J; Rabinowitz, Joshua D; Cantley, Lewis C; Blenis, John 2017. Post-transcriptional Regulation of De Novo Lipogenesis by mTORC1-S6K1-SRPK2 Signaling. Cell, 171 7, 1545-1558.e18

Li, Chenggang; Liu, Xiaolei; Liu, Yang; Zhang, Erik; Medepalli, Kantha; Masuda, Kouhei; Li, Na; Wikenheiser-Brokamp, Kathryn A; Osterburg, Andrew; Borchers, Michael T; Kopras, Elizabeth J; Plas, David R; Sun, Julia; Franz, David N; Capal, Jamie K; Mays, Maxwell; Sun, Yang; Kwiatkowski, David J; Alayev, Anya; Holz, Marina K; Krueger, Darcy A; Siroky, Brian J; Yu, Jane J 2017. Tuberin Regulates Prostaglandin Receptor-Mediated Viability, via Rheb, in mTORC1-Hyperactive Cells. Molecular cancer research : MCR, 15 10, 1318-1330

Li, Na; Lu, Yanjuan; Li, Daoming; Zheng, Xiangyu; Lian, Jingyao; Li, Shanshan; Cui, Huijuan; Zhang, Linda; Sang, Luqian; Wang, Ying; Yu, Jane J; Lu, Taiying 2017. All-trans retinoic acid suppresses the angiopoietin-Tie2 pathway and inhibits angiogenesis and metastasis in esophageal squamous cell carcinoma. PloS one, 12 4, e0174555

Li, Xiangke; Liu, Xiaolei; Zhang, Linda; Li, Chenggang; Zhang, Erik; Ma, Wang; Fan, Qingxia; Yu, Jane J 2017. Insulin growth factor binding protein 2 mediates the progression of lymphangioleiomyomatosis. Oncotarget, 8 22, 36628-36638

Lv, Zhuan; Yu, Jane J; Zhang, Wei-Jie; Xiong, Li; Wang, Feng; Li, Li-Feng; Zhou, Xue-Liang; Gao, Xin-Ya; Ding, Xian-Fei; Han, Li; Cai, Ya-Fei; Ma, Wang; Wang, Liu-Xing 2017. Expression and functional regulation of stemness gene Lgr5 in esophageal squamous cell carcinoma. Oncotarget, 8 16, 26492-26504

Goldberg, Alexander A; Joung, Kwang-Bo; Mansuri, Asma; Kang, Yujin; Echavarria, Raquel; Nikolajev, Ljiljana; Sun, Yang; Yu, Jane J; Laporte, Stephane A; Schwertani, Adel; Kristof, Arnold S 2016. Oncogenic effects of urotensin-II in cells lacking tuberous sclerosis complex-2. Oncotarget, 7 38, 61152-61165

Gu, Hongjing; Xie, Zhengde; Li, Tieling; Zhang, Shaogeng; Lai, Chengcai; Zhu, Ping; Wang, Keyu; Han, Lina; Duan, Yueqiang; Zhao, Zhongpeng; Yang, Xiaolan; Xing, Li; Zhang, Peirui; Wang, Zhouhai; Li, Ruisheng; Yu, Jane J; Wang, Xiliang; Yang, Penghui 2016. Angiotensin-converting enzyme 2 inhibits lung injury induced by respiratory syncytial virus. Scientific reports, 6 , 19840

He, Jing; Zhou, Mingxia; Chen, Xinfeng; Yue, Dongli; Yang, Li; Qin, Guohui; Zhang, Zhen; Gao, Qun; Wang, Dan; Zhang, Chaoqi; Huang, Lan; Wang, Liping; Zhang, Bin; Yu, Jane; Zhang, Yi 2016. Inhibition of SALL4 reduces tumorigenicity involving epithelial-mesenchymal transition via Wnt/?-catenin pathway in esophageal squamous cell carcinoma. Journal of experimental & clinical cancer research : CR, 35 1, 98

Jiang, Zhiqiang; Lao, Taotao; Qiu, Weiliang; Polverino, Francesca; Gupta, Kushagra; Guo, Feng; Mancini, John D; Naing, Zun Zar Chi; Cho, Michael H; Castaldi, Peter J; Sun, Yang; Yu, Jane; Laucho-Contreras, Maria E; Kobzik, Lester; Raby, Benjamin A; Choi, Augustine M K; Perrella, Mark A; Owen, Caroline A; Silverman, Edwin K; Zhou, Xiaobo 2016. A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of ?-Catenin. American journal of respiratory and critical care medicine, 194 2, 185-97

Li, Chenggang; Li, Na; Liu, Xiaolei; Zhang, Erik Y; Sun, Yang; Masuda, Kouhei; Li, Jing; Sun, Julia; Morrison, Tasha; Li, Xiangke; Chen, Yuanguang; Wang, Jiang; Karim, Nagla A; Zhang, Yi; Blenis, John; Reginato, Mauricio J; Henske, Elizabeth P; Yu, Jane J 2016. Proapoptotic protein Bim attenuates estrogen-enhanced survival in lymphangioleiomyomatosis. JCI insight, 1 19, e86629

Li, Jing; Shin, Sejeong; Sun, Yang; Yoon, Sang-Oh; Li, Chenggang; Zhang, Erik; Yu, Jane; Zhang, Jianming; Blenis, John 2016. mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress. Cancer research, 76 16, 4816-27

Alayev, Anya; Salamon, Rachel S; Sun, Yang; Schwartz, Naomi S; Li, Chenggang; Yu, Jane J; Holz, Marina K 2015. Effects of combining rapamycin and resveratrol on apoptosis and growth of TSC2-deficient xenograft tumors. American journal of respiratory cell and molecular biology, 53 5, 637-46

Li, Jing; Csibi, Alfredo; Yang, Sun; Hoffman, Gregory R; Li, Chenggang; Zhang, Erik; Yu, Jane J; Blenis, John 2015. Synthetic lethality of combined glutaminase and Hsp90 inhibition in mTORC1-driven tumor cells. Proceedings of the National Academy of Sciences of the United States of America, 112 1, E21-9

Medvetz, Doug; Sun, Yang; Li, Chenggang; Khabibullin, Damir; Balan, Murugabaskar; Parkhitko, Andrey; Priolo, Carmen; Asara, John M; Pal, Soumitro; Yu, Jane; Henske, Elizabeth P 2015. High-throughput drug screen identifies chelerythrine as a selective inducer of death in a TSC2-null setting. Molecular cancer research : MCR, 13 1, 50-62

Priolo, Carmen; Ricoult, Stéphane J H; Khabibullin, Damir; Filippakis, Harilaos; Yu, Jane; Manning, Brendan D; Clish, Clary; Henske, Elizabeth P 2015. Tuberous sclerosis complex 2 loss increases lysophosphatidylcholine synthesis in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 53 1, 33-41

Alayev, Anya; Sun, Yang; Snyder, Rose B; Berger, Sara Malka; Yu, Jane J; Holz, Marina K 2014. Resveratrol prevents rapamycin-induced upregulation of autophagy and selectively induces apoptosis in TSC2-deficient cells. Cell cycle (Georgetown, Tex.), 13 3, 371-82

Khabibullin, Damir; Medvetz, Douglas A; Pinilla, Miguel; Hariharan, Venkatesh; Li, Chenggang; Hergrueter, Anja; Laucho Contreras, Maria; Zhang, Erik; Parkhitko, Andrey; Yu, Jane J; Owen, Caroline A; Huang, Hayden; Baron, Rebecca M; Henske, Elizabeth P 2014. Folliculin regulates cell-cell adhesion, AMPK, and mTORC1 in a cell-type-specific manner in lung-derived cells. Physiological reports, 2 8,

Li, Chenggang; Lee, Po-Shun; Sun, Yang; Gu, Xiaoxiao; Zhang, Erik; Guo, Yanan; Wu, Chin-Lee; Auricchio, Neil; Priolo, Carmen; Li, Jing; Csibi, Alfredo; Parkhitko, Andrey; Morrison, Tasha; Planaguma, Anna; Kazani, Shamsah; Israel, Elliot; Xu, Kai-Feng; Henske, Elizabeth Petri; Blenis, John; Levy, Bruce D; Kwiatkowski, David; Yu, Jane J 2014. Estradiol and mTORC2 cooperate to enhance prostaglandin biosynthesis and tumorigenesis in TSC2-deficient LAM cells. The Journal of experimental medicine, 211 1, 15-28

Li, Chenggang; Zhang, Erik; Sun, Yang; Lee, Po-Shun; Zhan, Yongzhong; Guo, Yanan; Osorio, Juan C; Rosas, Ivan O; Xu, Kai-Feng; Kwiatkowski, David J; Yu, Jane J 2014. Rapamycin-insensitive up-regulation of adipocyte phospholipase A2 in tuberous sclerosis and lymphangioleiomyomatosis. PloS one, 9 10, e104809

Parkhitko, Andrey A; Priolo, Carmen; Coloff, Jonathan L; Yun, Jihye; Wu, Julia J; Mizumura, Kenji; Xu, Wenping; Malinowska, Izabela A; Yu, Jane; Kwiatkowski, David J; Locasale, Jason W; Asara, John M; Choi, Augustine M K; Finkel, Toren; Henske, Elizabeth P 2014. Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. Molecular cancer research : MCR, 12 1, 48-57

Sun, Y; Gu, X; Zhang, E; Park, M-A; Pereira, A M; Wang, S; Morrison, T; Li, C; Blenis, J; Gerbaudo, V H; Henske, E P; Yu, J J 2014. Estradiol promotes pentose phosphate pathway addiction and cell survival via reactivation of Akt in mTORC1 hyperactive cells. Cell death & disease, 5 , e1231

Sun, Yang; Gallacchi, Dana; Zhang, Erik Y; Reynolds, Samuel B; Robinson, Lauren; Malinowska, Izabela A; Chiou, Terry T; Pereira, Ana M; Li, Chenggang; Kwiatkowski, David J; Lee, Po-Shun; Yu, Jane J 2014. Rapamycin-resistant poly (ADP-ribose) polymerase-1 overexpression is a potential therapeutic target in lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 51 6, 738-49

Sun, Yang; Zhang, Erik; Lao, Taotao; Pereira, Ana M; Li, Chenggang; Xiong, Li; Morrison, Tasha; Haley, Kathleen J; Zhou, Xiaobo; Yu, Jane J 2014. Progesterone and estradiol synergistically promote the lung metastasis of tuberin-deficient cells in a preclinical model of lymphangioleiomyomatosis. Hormones & cancer, 5 5, 284-98

Yang, Ping; Cornejo, Kristine M; Sadow, Peter M; Cheng, Liang; Wang, Mingsheng; Xiao, Yu; Jiang, Zhong; Oliva, Esther; Jozwiak, Sergiusz; Nussbaum, Robert L; Feldman, Adam S; Paul, Elahna; Thiele, Elizabeth A; Yu, Jane J; Henske, Elizabeth P; Kwiatkowski, David J; Young, Robert H; Wu, Chin-Lee 2014. Renal cell carcinoma in tuberous sclerosis complex. The American journal of surgical pathology, 38 7, 895-909

Yu, Jane 2014. Reply: hormonally targeted therapy for women with lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 50 3, 665

Csibi, Alfred; Fendt, Sarah-Maria; Li, Chenggang; Poulogiannis, George; Choo, Andrew Y; Chapski, Douglas J; Jeong, Seung Min; Dempsey, Jamie M; Parkhitko, Andrey; Morrison, Tasha; Henske, Elizabeth P; Haigis, Marcia C; Cantley, Lewis C; Stephanopoulos, Gregory; Yu, Jane; Blenis, John 2013. The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4. Cell, 153 4, 840-54

Gu, Xiaoxiao; Yu, Jane J; Ilter, Didem; Blenis, Nickolas; Henske, Elizabeth Petri; Blenis, John 2013. Integration of mTOR and estrogen-ERK2 signaling in lymphangioleiomyomatosis pathogenesis. Proceedings of the National Academy of Sciences of the United States of America, 110 37, 14960-5

Li, Chenggang; Zhou, Xiaobo; Sun, Yang; Zhang, Erik; Mancini, John D; Parkhitko, Andrey; Morrison, Tasha A; Silverman, Edwin K; Henske, Elizabeth P; Yu, Jane J 2013. Faslodex inhibits estradiol-induced extracellular matrix dynamics and lung metastasis in a model of lymphangioleiomyomatosis. American journal of respiratory cell and molecular biology, 49 1, 135-42

Trindade, Anil J; Medvetz, Douglas A; Neuman, Nicole A; Myachina, Faina; Yu, Jane; Priolo, Carmen; Henske, Elizabeth P 2013. MicroRNA-21 is induced by rapamycin in a model of tuberous sclerosis (TSC) and lymphangioleiomyomatosis (LAM). PloS one, 8 3, e60014

Liu, Fangbing; Lunsford, Elaine P; Tong, Jingli; Ashitate, Yoshitomo; Gibbs, Summer L; Yu, Jane; Choi, Hak Soo; Henske, Elizabeth P; Frangioni, John V 2012. Real-time monitoring of tumorigenesis, dissemination, & drug response in a preclinical model of lymphangioleiomyomatosis/tuberous sclerosis complex. PloS one, 7 6, e38589

Yu, Jane; Henske, Elizabeth Petri 2011. TORC1 activation and autophagy inhibition: opposing forces in Rheb-driven tumorigenesis. Cell cycle (Georgetown, Tex.), 10 22, 3803-4

Yu, Jane; Parkhitko, Andrey; Henske, Elizabeth Petri 2011. Autophagy: an 'Achilles' heel of tumorigenesis in TSC and LAM. Autophagy, 7 11, 1400-1

Karbowniczek, Magdalena; Zitserman, Diana; Khabibullin, Damir; Hartman, Tiffiney; Yu, Jane; Morrison, Tasha; Nicolas, Emmanuelle; Squillace, Rachel; Roegiers, Fabrice; Henske, Elizabeth Petri 2010. The evolutionarily conserved TSC/Rheb pathway activates Notch in tuberous sclerosis complex and Drosophila external sensory organ development. The Journal of clinical investigation, 120 1, 93-102

Yu, Jane; Henske, Elizabeth Petri 2010. mTOR activation, lymphangiogenesis, and estrogen-mediated cell survival: the "perfect storm" of pro-metastatic factors in LAM pathogenesis. Lymphatic research and biology, 8 1, 43-9

Yu, Jane; Parkhitko, Andrey A; Henske, Elizabeth Petri 2010. Mammalian target of rapamycin signaling and autophagy: roles in lymphangioleiomyomatosis therapy. Proceedings of the American Thoracic Society, 7 1, 48-53

Yu, Jane J; Robb, Victoria A; Morrison, Tasha A; Ariazi, Eric A; Karbowniczek, Magdalena; Astrinidis, Aristotelis; Wang, Chunrong; Hernandez-Cuebas, Lisa; Seeholzer, Laura F; Nicolas, Emmanuelle; Hensley, Harvey; Jordan, V Craig; Walker, Cheryl L; Henske, Elizabeth P 2009. Estrogen promotes the survival and pulmonary metastasis of tuberin-null cells. Proceedings of the National Academy of Sciences of the United States of America, 106 8, 2635-40

Li, Faqiang; Vallabhaneni, Ratnakar; Yu, Jane; Rocheford, Torbert; Wurtzel, Eleanore T 2008. The maize phytoene synthase gene family: overlapping roles for carotenogenesis in endosperm, photomorphogenesis, and thermal stress tolerance. Plant physiology, 147 3, 1334-46

Yu, Jane; Henske, Elizabeth Petri 2006. Estrogen-induced activation of mammalian target of rapamycin is mediated via tuberin and the small GTPase Ras homologue enriched in brain. Cancer research, 66 19, 9461-6

Yu, Jane; Astrinidis, Aristotelis; Howard, Sharon; Henske, Elizabeth Petri 2004. Estradiol and tamoxifen stimulate LAM-associated angiomyolipoma cell growth and activate both genomic and nongenomic signaling pathways. American journal of physiology. Lung cellular and molecular physiology, 286 4, L694-700

Karbowniczek, Magdalena; Yu, Jane; Henske, Elizabeth Petri 2003. Renal angiomyolipomas from patients with sporadic lymphangiomyomatosis contain both neoplastic and non-neoplastic vascular structures. The American journal of pathology, 162 2, 491-500

Yu, J; Astrinidis, A; Henske, E P 2001. Chromosome 16 loss of heterozygosity in tuberous sclerosis and sporadic lymphangiomyomatosis. American journal of respiratory and critical care medicine, 164 8 Pt 1, 1537-40