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Pathobiology & Molecular Medicine

Photo of Jason Gardner

Jason Gardner

Research Interests

The overarching goal of our laboratory is to understand the axis of cytokines, signaling pathways and cellular responses that lead to complications and poor outcomes in the critically ill. Ongoing work in our laboratory is focused on developing interventional strategies that will improve outcomes in patients with pneumonia or anemia.

Education/Credentials
  • PhD: University of Cincinnati
  • BS: Indiana University
Contact Information

Peer Reviewed Publications

Nikolaidis, Nikolaos M; Noel, John G; Pitstick, Lori B; Gardner, Jason C; Uehara, Yasuaki; Wu, Huixing; Saito, Atsushi; Lewnard, Kara E; Liu, Huan; White, Mitchell R; Hartshorn, Kevan L; McCormack, Francis X 2017. Mitogenic stimulation accelerates influenza-induced mortality by increasing susceptibility of alveolar type II cells to infection. Proceedings of the National Academy of Sciences of the United States of America, ,

Noel, John G; Ramser, Benjamin J; Cancelas, Jose A; McCormack, Francis X; Gardner, Jason C 2017. Thermal injury of the skin induces G-CSF-dependent attenuation of EPO-mediated STAT signaling and erythroid differentiation arrest in mice. Experimental hematology, 56 , 16-30

Gardner, J. C.; Wu, H.; Noel, J. G.; Ramser, B. J.; Pitstick, L.; Saito, A.; Nikolaidis, N. M.; McCormack, F. X. 2016. Keratinocyte growth factor supports pulmonary innate immune defense through maintenance of alveolar antimicrobial protein levels and macrophage function Am J Physiol Lung Cell Mol Physiol, 310 9 , L868-79

Pasula, R.; Azad, A. K.; Gardner, J. C.; Schlesinger, L. S.; McCormack, F. X. 2015. Keratinocyte growth factor administration attenuates murine pulmonary mycobacterium tuberculosis infection through granulocyte-macrophage colony-stimulating factor (GM-CSF)-dependent macrophage activation and phagolysosome fusion J Biol Chem, 290 11 , 7151-9

Saito, A.; Nikolaidis, N. M.; Amlal, H.; Uehara, Y.; Gardner, J. C.; LaSance, K.; Pitstick, L. B.; Bridges, J. P.; Wikenheiser-Brokamp, K. A.; McGraw, D. W.; Woods, J. C.; Sabbagh, Y.; Schiavi, S. C.; Altinisik, G.; Jakopovic, M.; Inoue, Y.; McCormack, F. X. 2015. Modeling pulmonary alveolar microlithiasis by epithelial deletion of the Npt2b sodium phosphate cotransporter reveals putative biomarkers and strategies for treatment Sci Transl Med, 7 313 , 313ra181

Gardner, J. C.; Noel, J. G.; Nikolaidis, N. M.; Karns, R.; Aronow, B. J.; Ogle, C. K.; McCormack, F. X. 2014. G-CSF drives a posttraumatic immune program that protects the host from infection J Immunol, 192 5 , 2405-17

Healy, D. P.; Sombun, A. D.; Gardner, J. C.; Good, K.; Durkee, P. J.; Toner, L.; Rieman, M. T.; Neely, A. N.; Kagan, R. J. 2011. Pharmacokinetics of colistin in an adolescent boy with extensive burn injury J Burn Care Res, 32 1 , e7-11

Dugan, A. L.; Gregerson, K. A.; Neely, A.; Gardner, J.; Noel, G. J.; Babcock, G. F.; Horseman, N. D. 2010. Mice treated with a benzodiazepine had an improved survival rate following Pseudomonas aeruginosa infection J Burn Care Res, 31 1 , 1-12

Neely, A. N.; Gardner, J.; Durkee, P.; Warden, G. D.; Greenhalgh, D. G.; Gallagher, J. J.; Herndon, D. N.; Tompkins, R. G.; Kagan, R. J. 2009. Are topical antimicrobials effective against bacteria that are highly resistant to systemic antibiotics? J Burn Care Res, 30 1 , 19-29

Osterburg, A.; Gardner, J.; Hyon, S. H.; Neely, A.; Babcock, G. 2009. Highly antibiotic-resistant Acinetobacter baumannii clinical isolates are killed by the green tea polyphenol (-)-epigallocatechin-3-gallate (EGCG) Clin Microbiol Infect, 15 4 , 341-6

Supp, D. M.; Gardner, J.; Klingenberg, J. M.; Neely, A. N. 2009. Antibiotic resistance in clinical isolates of Acinetobacter baumannii, Pseudomonas aeruginosa, and Staphylococcus aureus does not impact sensitivity to human beta defensin 4 Burns, 35 7 , 949-55

Tschop, J.; Martignoni, A.; Reid, M. D.; Adediran, S. G.; Gardner, J.; Noel, G. J.; Ogle, C. K.; Neely, A. N.; Caldwell, C. C. 2009. Differential immunological phenotypes are exhibited after scald and flame burns Shock, 31 2 , 157-63

DiGiandomenico, A.; Rao, J.; Harcher, K.; Zaidi, T. S.; Gardner, J.; Neely, A. N.; Pier, G. B.; Goldberg, J. B. 2007. Intranasal immunization with heterologously expressed polysaccharide protects against multiple Pseudomonas aeruginosa infections Proc Natl Acad Sci U S A, 104 11 , 4624-9

Healy, Daniel P.; Gardner, Jason C.; Puthoff, Barbara K.; Kagan, Richard J.; Neely, Alice N. 2007. Antibiotic-mediated bacterial filamentation: A potentially important laboratory phenomenon Clinical Microbiology Newsletter, 29 3 , 22-24

Smiley, A. K.; Gardner, J.; Klingenberg, J. M.; Neely, A. N.; Supp, D. M. 2007. Expression of human beta defensin 4 in genetically modified keratinocytes enhances antimicrobial activity J Burn Care Res, 28 1 , 127-32

Neely, A. N.; Regnold, L. A.; Hayes, S.; Gardner, J.; Cahill, T. J. 2006. Redesign of portable suction equipment cases: an engineering approach to a disinfection problem Am J Infect Control, 34 5 , 281-4

Neely, A. N.; Mayes, T.; Gardner, J.; Kagan, R. J.; Gottschlich, M. M. 2006. A microbiologic study of enteral feeding hang time in a burn hospital: can feeding costs be reduced without compromising patient safety? Nutr Clin Pract, 21 6 , 610-6

Neely, A. N.; Clendening, C. E.; Gardner, J.; Greenhalgh, D. G. 2000. Gelatinase activities in wounds of healing-impaired mice versus wounds of non-healing-impaired mice J Burn Care Rehabil, 21 5 , 395-402

Neely, A. N.; Clendening, C. E.; Gardner, J.; Greenhalgh, D. G.; Warden, G. D. 1999. Gelatinase activity in keloids and hypertrophic scars Wound Repair Regen, 7 3 , 166-71

Neely, A. N.; Brown, R. L.; Clendening, C. E.; Orloff, M. M.; Gardner, J.; Greenhalgh, D. G. 1997. Proteolytic activity in human burn wounds Wound Repair Regen, 5 4 , 302-9