Today is Tuesday, Aug. 11, 2020

Department of

Neuroscience Graduate Program

Photo of  Rolf Stottmann, Ph.D.

Rolf Stottmann, Ph.D.

Assistant Professor of Pediatrics

  • Ph.D.: Duke University School of Medicine
  • M.S.: University of Maryland, College Park
  • B.S.: University of Maryland, College Park
Contact Information
  • CCHMC R.1033
  • MLC 7016
  • 3333 Burnet Ave
  • Cincinnati, Ohio 45229
  • Office 513-636-7136
  • Fax 513-636-4373
  • Email

Peer Reviewed Publications

Ha, Seungshin; Stottmann, Rolf W; Furley, Andrew J; Beier, David R 2013. A Forward Genetic Screen in Mice Identifies Mutants with Abnormal Cortical Patterning. Cerebral cortex (New York, N.Y. : 1991), ,

Stottmann, R W; Donlin, M; Hafner, A; Bernard, A; Sinclair, D A; Beier, D R 2013. A mutation in Tubb2b, a human polymicrogyria gene, leads to lethality and abnormal cortical development in the mouse. Human molecular genetics, 22 20, 4053-63

Leshchiner, Ignaty; Alexa, Kristen; Kelsey, Peter; Adzhubei, Ivan; Austin-Tse, Christina A; Cooney, Jeffrey D; Anderson, Heidi; King, Matthew J; Stottmann, Rolf W; Garnaas, Maija K; Ha, Seungshin; Drummond, Iain A; Paw, Barry H; North, Trista E; Beier, David R; Goessling, Wolfram; Sunyaev, Shamil R 2012. Mutation mapping and identification by whole-genome sequencing. Genome research, 22 8, 1541-8

Stottmann, R W; Moran, J L; Turbe-Doan, A; Driver, E; Kelley, M; Beier, D R 2011. Focusing forward genetics: a tripartite ENU screen for neurodevelopmental mutations in the mouse. Genetics, 188 3, 615-24

Stottmann, Rolf W; Klingensmith, John 2011. Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. Developmental dynamics : an official publication of the American Association of Anatomists, 240 4, 755-65

Stottmann, Rolf W; Turbe-Doan, Annick; Tran, Pamela; Kratz, Lisa E; Moran, Jennifer L; Kelley, Richard I; Beier, David R 2011. Cholesterol metabolism is required for intracellular hedgehog signal transduction in vivo. PLoS genetics, 7 9, e1002224

Jaeger, Savina A; Chan, Esther T; Berger, Michael F; Stottmann, Rolf; Hughes, Timothy R; Bulyk, Martha L 2010. Conservation and regulatory associations of a wide affinity range of mouse transcription factor binding sites. Genomics, 95 4, 185-95

Stottmann, R W; Bjork, B C; Doyle, J B; Beier, D R 2010. Identification of a Van der Woude syndrome mutation in the cleft palate 1 mutant mouse. Genesis (New York, N.Y. : 2000), 48 5, 303-8

Stottmann, Rolf W; Beier, David R 2010. Using ENU mutagenesis for phenotype-driven analysis of the mouse. Methods in enzymology, 477 , 329-48

Stottmann, R W; Tran, P V; Turbe-Doan, A; Beier, D R 2009. Ttc21b is required to restrict sonic hedgehog activity in the developing mouse forebrain. Developmental biology, 335 1, 166-78

Tran, Pamela V; Haycraft, Courtney J; Besschetnova, Tatiana Y; Turbe-Doan, Annick; Stottmann, Rolf W; Herron, Bruce J; Chesebro, Allyson L; Qiu, Haiyan; Scherz, Paul J; Shah, Jagesh V; Yoder, Bradley K; Beier, David R 2008. THM1 negatively modulates mouse sonic hedgehog signal transduction and affects retrograde intraflagellar transport in cilia. Nature genetics, 40 4, 403-10

Choi, Murim; Stottmann, Rolf W; Yang, Yu-Ping; Meyers, Erik N; Klingensmith, John 2007. The bone morphogenetic protein antagonist noggin regulates mammalian cardiac morphogenesis. Circulation research, 100 2, 220-8

Anderson, Ryan M; Stottmann, Rolf W; Choi, Murim; Klingensmith, John 2006. Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. Developmental dynamics : an official publication of the American Association of Anatomists, 235 9, 2507-20

Stottmann, Rolf W; Berrong, Mark; Matta, Karen; Choi, Murim; Klingensmith, John 2006. The BMP antagonist Noggin promotes cranial and spinal neurulation by distinct mechanisms. Developmental biology, 295 2, 647-63

Stottmann, Rolf W; Choi, Murim; Mishina, Yuji; Meyers, Erik N; Klingensmith, John 2004. BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. Development (Cambridge, England), 131 9, 2205-18

Anderson, Ryan M; Lawrence, Alison R; Stottmann, Rolf W; Bachiller, Daniel; Klingensmith, John 2002. Chordin and noggin promote organizing centers of forebrain development in the mouse. Development (Cambridge, England), 129 21, 4975-87

Stottmann, R W; Anderson, R M; Klingensmith, J 2001. The BMP antagonists Chordin and Noggin have essential but redundant roles in mouse mandibular outgrowth. Developmental biology, 240 2, 457-73

Stottmann, R W; Rivas, R J 1998. Distribution of TAG-1 and synaptophysin in the developing cerebellar cortex: relationship to Purkinje cell dendritic development. The Journal of comparative neurology, 395 1, 121-35

Bauer, Kim A; George, Timothy M; Enterline, David S; Stottmann, Rolf W; Melvin, Elizabeth C; Siegel, Deborah; Samal, Surekha; Hauser, Michael A; Klingensmith, John; Nye, Jeffery S; Speer, Marcy C . A novel mutation in the gene encoding noggin is not causative in human neural tube defects. Journal of neurogenetics, 16 1, 65-71

Beckstead, Wesley A; Bjork, Bryan C; Stottmann, Rolf W; Sunyaev, Shamil; Beier, David R . SNP2RFLP: a computational tool to facilitate genetic mapping using benchtop analysis of SNPs. Mammalian genome : official journal of the International Mammalian Genome Society, 19 10-12, 687-90

Tran, Pamela V; Lachke, Salil A; Stottmann, Rolf W . Toward a systems-level understanding of the Hedgehog signaling pathway: defining the complex, robust, and fragile. Wiley interdisciplinary reviews. Systems biology and medicine, 5 1, 83-100