Today is Saturday, Aug. 15, 2020

Department of

Neuroscience Graduate Program

Photo of  Matthew Skelton, PhD

Matthew Skelton, PhD

Assistant Professor

Research Interests

Pediatric Neurology

Education/Credentials
  • Doctoral Degree: University of Cincinnati
  • Bachelor's Degree: Bellarmine University
Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnet Ave
  • Cincinnati, Ohio 45229
  • Office 513-636-4222
  • Email matthew.skelton@cchmc.org

Peer Reviewed Publications

Braun, Amanda A; Amos-Kroohs, Robyn M; Gutierrez, Arnold; Lundgren, Kerstin H; Seroogy, Kim B; Skelton, Matthew R; Vorhees, Charles V; Williams, Michael T 2015. Dopamine depletion in either the dorsomedial or dorsolateral striatum impairs egocentric Cincinnati water maze performance while sparing allocentric Morris water maze learning. Neurobiology of learning and memory, 118 , 55-63

Hautman, Emily R; Kokenge, Amanda N; Udobi, Kenea C; Williams, Michael T; Vorhees, Charles V; Skelton, Matthew R 2014. Female mice heterozygous for creatine transporter deficiency show moderate cognitive deficits. Journal of inherited metabolic disease, 37 1, 63-8

Russell, Aaron P; Ghobrial, Lobna; Wright, Craig R; Lamon, Séverine; Brown, Erin L; Kon, Michihiro; Skelton, Matthew R; Snow, Rodney J 2014. Creatine transporter (SLC6A8) knockout mice display an increased capacity for in vitro creatine biosynthesis in skeletal muscle. Frontiers in physiology, 5 , 314

Vorhees, Charles V; Graham, Devon L; Amos-Kroohs, Robyn M; Braun, Amanda A; Grace, Curtis E; Schaefer, Tori L; Skelton, Matthew R; Erikson, Keith M; Aschner, Michael; Williams, Michael T 2014. Effects of developmental manganese, stress, and the combination of both on monoamines, growth, and corticosterone. Toxicology reports, 1 , 1046-1061

Williams, Michael T; Skelton, Matthew R; Longacre, Ian D; Huggins, Kimberly N; Maple, Amanda M; Vorhees, Charles V; Brown, Russell W 2014. Neuronal reorganization in adult rats neonatally exposed to (±)-3,4-methylenedioxymethamphetamine. Toxicology reports, 1 , 699-706

Schaefer, Tori L; Grace, Curtis E; Braun, Amanda A; Amos-Kroohs, Robyn M; Graham, Devon L; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V 2013. Cognitive impairments from developmental exposure to serotonergic drugs: citalopram and MDMA. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 16 6, 1383-94

Skelton, Matthew R; Graham, Devon L; Schaefer, Tori L; Grace, Curtis E; Braun, Amanda A; Burns, Lindsey N; Amos-Kroohs, Robyn M; Williams, Michael T; Vorhees, Charles V 2012. Distinct periods of developmental sensitivity to the effects of 3,4-(±)-methylenedioxymethamphetamine (MDMA) on behaviour and monoamines in rats. The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP), 15 6, 811-24

Wong, Ann Chi Yan; Velamoor, Sailakshmi; Skelton, Matthew R; Thorne, Peter R; Vlajkovic, Srdjan M 2012. Expression and distribution of creatine transporter and creatine kinase (brain isoform) in developing and mature rat cochlear tissues. Histochemistry and cell biology, 137 5, 599-613

Curran, Christine P; Nebert, Daniel W; Genter, Mary Beth; Patel, Krishna V; Schaefer, Tori L; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V 2011. In utero and lactational exposure to PCBs in mice: adult offspring show altered learning and memory depending on Cyp1a2 and Ahr genotypes. Environmental health perspectives, 119 9, 1286-93

Skelton, Matthew R; Schaefer, Tori L; Graham, Devon L; Degrauw, Ton J; Clark, Joseph F; Williams, Michael T; Vorhees, Charles V 2011. Creatine transporter (CrT; Slc6a8) knockout mice as a model of human CrT deficiency. PloS one, 6 1, e16187

Sun, Ying; Liou, Benjamin; Ran, Huimin; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V; Kitatani, Kazuyuki; Hannun, Yusuf A; Witte, David P; Xu, You-Hai; Grabowski, Gregory A 2010. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Human molecular genetics, 19 6, 1088-97

Sun, Ying; Ran, Huimin; Zamzow, Matt; Kitatani, Kazuyuki; Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V; Witte, David P; Hannun, Yusuf A; Grabowski, Gregory A 2010. Specific saposin C deficiency: CNS impairment and acid beta-glucosidase effects in the mouse. Human molecular genetics, 19 4, 634-47

Skelton, Matthew R; Schaefer, Tori L; Herring, Nicole R; Grace, Curtis E; Vorhees, Charles V; Williams, Michael T 2009. Comparison of the developmental effects of 5-methoxy-N,N-diisopropyltryptamine (Foxy) to (+/-)-3,4-methylenedioxymethamphetamine (ecstasy) in rats. Psychopharmacology, 204 2, 287-97

Skelton, Matthew R; Able, Jessica A; Grace, Curtis E; Herring, Nicole R; Schaefer, Tori L; Gudelsky, Gary A; Vorhees, Charles V; Williams, Michael T 2008. (+/-)-3,4-Methylenedioxymethamphetamine treatment in adult rats impairs path integration learning: a comparison of single vs once per week treatment for 5 weeks. Neuropharmacology, 55 7, 1121-30

Skelton, Matthew R; Williams, Michael T; Vorhees, Charles V 2008. Developmental effects of 3,4-methylenedioxymethamphetamine: a review. Behavioural pharmacology, 19 2, 91-111

Sun, Ying; Witte, David P; Ran, Huimin; Zamzow, Matt; Barnes, Sonya; Cheng, Hua; Han, Xianlin; Williams, Michael T; Skelton, Matthew R; Vorhees, Charles V; Grabowski, Gregory A 2008. Neurological deficits and glycosphingolipid accumulation in saposin B deficient mice. Human molecular genetics, 17 15, 2345-56

Skelton, Matthew R; Williams, Michael T; Schaefer, Tori L; Vorhees, Charles V 2007. Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits. Psychoneuroendocrinology, 32 6, 734-45

Skelton, Matthew R; Blankenmeyer, Tracy L; Gudelsky, Gary A; Brown-Strittholt, Carrie A; Vorhees, Charles V; Williams, Michael T 2004. Metyrapone attenuates the sequential learning deficits but not monoamine depletions following d,l-fenfluramine administration to adult rats. Synapse (New York, N.Y.), 54 4, 214-22

Skelton, Matthew R; Ponniah, Sathivel; Wang, Dennis Z-M; Doetschman, Thomas; Vorhees, Charles V; Pallen, Catherine J 2003. Protein tyrosine phosphatase alpha (PTP alpha) knockout mice show deficits in Morris water maze learning, decreased locomotor activity, and decreases in anxiety. Brain research, 984 1-2, 1-10

Vorhees, Charles V; Graham, Devon L; Braun, Amanda A; Schaefer, Tori L; Skelton, Matthew R; Richtand, Neil M; Williams, Michael T . Prenatal immune challenge in rats: effects of polyinosinic-polycytidylic acid on spatial learning, prepulse inhibition, conditioned fear, and responses to MK-801 and amphetamine. Neurotoxicology and teratology, 47 , 54-65