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Department of Pharmacology & Systems Physiology

Master’s Program in Pharmacology

MS Program Research Interests

Mentor & Department* Research Interests
Zalfa Abdel-Malek, PhD
Department of Dermatology
Regulation of human pigmentation, photobiology and photocarcinogenesis, genetic susceptibility to melanoma; role of melanocortins and the melanocortin 1 receptor
Hassane Amlal, PhD
Internal Medicine
Nephrology
Regulation of acid-base transporters, glutamine metabolism, and inorganic phosphate in health and disease
Mark Baccei, PhD
Department of Anesthesiology
Characterization of the short- and long-term consequences of tissue injury during early life for the function of developing synaptic networks in the superficial dorsal horn of the spinal cord
George Deepe, MD
Department of Internal Medicine
Division of Infectious Diseases
Cellular immunology of fungal infections; characterization of the protective T-cell epitopes of H. capsulatum antigens and analysis of the functional activity of antigen-reactive T-cells 
Senad Divanovic, PhD
Cincinnati Children's
Division of Immunobiology
Our research program focuses on the role of immune response in inflammation and metabolism. Our expertise in pathways that regulate innate immunity — developed through the pursuit of studies ranging from reductive analysis of TLR ligand signaling to the role of IL-17 axis in experimental models of obesity and infection — have spearheaded the projects aimed at defining the role of the immune mediators in the development and progression of obesity, obesity-associated sequelae and infection / inflammation driven preterm birth. 
Guochang Fan, PhD
Department of Pharmacology and Systems Physiology
Regulatory roles of microRNAs and exosome signaling pathway in sepsis-, diabetes- and infarction-induced heart failure; 2) protective roles of stem cell-derived exosomes in cardiovascular disease; and 3) the influence of microRNAs on bone marrow-derived mesenchymal stem cell behavior
James Herman, PhD
Department of Psychiatry and Behavior Neuroscience
1) limbic system regulation of the stress response and, consequently, on the generation of stress-related disorders, ranging from major depressive illness to essential hypertension to neurodegeneration and aging, and
2) defining the role of central adrenocorticosteroid receptors in transducing stress-related signals in normal physiology, aging and disease states.
Christy Holland, PhD
UC Internal Medicine
Division of Cardiovascular Diseases
 

Bioeffects of Diagnostic and Therapeutic Ultrasound, Acoustic Cavitation, New Diagnostic imaging Techniques for the Early Detection of Vascular Disease and Ischemic Injury to Brain

David Hui, PhD
Department of Pathology and Laboratory Medicine
Lipid Metabolism, Atherosclerosis, Diabetes, Obesity, Vascular Biology

Our research program focuses on three specific areas relating cholesterol metabolism with individual susceptibility for coronary heart disease.
Jeffrey Molkentin, PhD
Cincinnati Children's
Division of Molecular Cardiovascular Biology
Molecular biology of heart and skeletal muscle disease
Andy Norman, PhD
Department of Pharmacology and Systems Physiology
Development of quantitative pharmacological models of addictive behavior. These models can then be used to predict the clinical efficacy of potential medications for the treatment of cocaine and other addictions. Dr. Norman leads a multidisciplinary team that is developing human anti-cocaine monoclonal antibodies suitable for use as therapeutic agents for the prevention of relapse in cocaine addicts.
Joseph Qualls, PhD
Cincinnati Children's
Division of Infectious Diseases
Immunology; innate immunity; macrophage biology; amino acid metabolism; intracellular pathogenesis 
Jack Rubinstein, MD
Department of Internal Medicine
Division of Cardiology
Advanced Echocardiographic Imaging, Myocardial Energy Utilization 
Laura Ramsey, PhD
Cincinnati Children's
Research in Patient Services
The Ramsey lab is interested in all aspects of pharmacogenetics, from basic research to implementation in patient care. Pharmacogenetics refers to the effect of a person’s genetic code on his/her response to a medication. Research has been done in this field for decades, but only recently has pharmacogenetic information been incorporated into clinical care. There are now guidelines for dosing of more than 30 drugs based on genetic information, provided by the NIH-funded Clinical Pharmacogenetics Implementation Consortium (CPIC). Many of the genes involved in response to medication alter the pharmacokinetics of the drug (the speed at which it’s absorbed, distributed, metabolized or eliminated). 
Sakthivel Sadayappan, PhD, MBA
Department of Internal Medicine
Division of Cardiology
The long-term goal of the Sadayappan Lab involves 1) elucidating the causes of muscle-specific diseases at the molecular level and 2) identifying therapeutic targets that will lead to the development of effective cures. The more specific objectives involve determining the up- and downstream regulators of sarcomere structure and function of both cardiac and skeletal muscles in health and disease. The sarcomere is the functional unit of striated muscle to generate contractility. 
Manoocher Soleimani, MD
Department of Internal Medicine
Division of Cardiology
Identification, Cloning and Examination of Genes Regulating Acid Base Transport in the Kidney, Salt Absorption in the Kidney Distal Nephron and Blood Pressure Regulation Through the Generation and Examination of Transgenic Mice, Identification and Examination of Genes that Play Important Roles in Either Promoting or Protecting Against Tissue Injury in Kidney Damage 
Saulius Sumanas, PhD
Cincinnati Children's
Division of Developmental Biology
 Blood vessel formation is tightly linked to different types of vascular diseases, wound healing, regeneration and cancer in humans. Mechanisms controlling blood vessel formation de novo, vasculogenesis, and blood vessels sprouting from the existing vessels, angiogenesis, are still poorly understood.
Tom Thompson, PhD
Department of Molecular Genetics
Study of the structural and functional aspects of TGFbeta family signaling and regulation along with the structures of apolipoproteins and how this relates to HDL particles and other related biological functions.  The laboratory uses a combination of structural techniques including X-ray crstallography, small angle X-ray scattering coupled with biophysical and biochemical experiments.
Michael Tranter, PhD
Department of Internal Medicine 
Division of Cardiology
The long-term goals of my research are to increase our understanding of the molecular mechanisms of cardiovascular disease. Within this realm, the ongoing work in the laboratory is broadly centered around post-transcriptional gene regulation in the setting of (1) pathological left ventricular hypertrophy and fibrosis, and (2) the mechanisms of cardioprotection against ischemia/reperfusion injury. 
Patrick Tso, PhD
Department of Pathology and Laboratory Medicine
One of our research goals is to gain a better understanding of the mechanisms and factors regulating intestinal lipid absorption and the assembly and secretion of chylomicrons and very low density lipoproteins by the small intestine.  The techniques we employ consist of conscious intestinal lymph fistula rats, lymph fistula mouse, intestinal epithelial cell culture, and also molecular biology.
Hong-Sheng Wang, PhD
Department of Pharmacology and Systems Physiology
Ion channels are pore-forming membrane proteins. Transmembrane ionic currents generated by ion channels are the basis of electrical activities of excitable tissues, including the heart. Alterations of ionic currents are a major factor in various cardiac diseases such as arrhythmias. We are interested in the role of ion channels in controlling the electrical and mechanical properties of cardiac cells. We are also interested in how alterations of ion channel expression and/or properties contribute to abnormal myocyte electrical and mechanical properties in various disease conditions such as heart failure and arrhythmias. We employ electrophysiology, protein chemistry and molecular biology techniques in the lab. In addition, we use mathematical modeling and the real-time dynamic clamp technique to address these questions. The later approach combines computer simulation with experimental biology, and allows us to simulate artificial ionic conductances in real, live cells. A second major focus of our lab is to understand both the acute effects of endogenous estrogen and environmental endocrine disrupters on the physiology of the heart and the role they play in cardiac diseases. 
Yi-Gang Wang, PhD
Department of Pathology and Laboratory Medicine
Currently, Dr. Wang's research activities focus on stem cell therapies using three animal models.  These models are myocardial infarction (MI) via ligation of the left anterior descending (LAD) coronary artery, heterotopic heart transplantation, and the use of a special cell patch to treat MI. These models are used to explore the role of progenitor cell differentiation, migration, and proliferation on protection and functional regeneration of injured heart tissue. 
Joshua Waxman, PhD
Cincinnati Children's
Division of Molecular Cardiovascular Biology
The Waxman Lab uses genetic, molecular and cellular biological techniques to understand the underlying mechanisms of congenital heart defects and cardiomyocyte formation during development.
Jun-Ming Zhang, MD
Department of Anesthesiology 
Physiology and pathophysiology of neuropathic pain, Sympathetic regulation of inflammatory response in pain, Mechanisms and management of low back pain, Sodium channels, ectopic discharges and pathological pain.  Specifically, we are interested in whether extended nerve block provides additional benefit for patients with traumatic injury in lowing the risk of chronic pain; and how to improve efficacy of epidural steroids for managing low back pain.    
Tongli Zhang, PhD
Department of Pharmacology and Systems Physiology
In my research, I combine biological intuition with mathematical modeling to make clear the seemingly confusing networks. My biological intuition is on cell cycle, apoptosis, p53 pathway and NF-κB pathway. My modeling expertise is on positive feedbacks, negative feedbacks, switches, and oscillations.  
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