Today is Monday, Aug. 3, 2020

Department of Internal Medicine

Immunology, Allergy and Rheumatology

Research Activity

The division's research productivity has been high, with more than 60 papers published in PubMed-cited journals since January 2003.

The adult and pediatric rheumatology divisions collaborate on research endeavors with both groups having combined research conferences and both playing critical roles in the establishment of a basic and translational immunobiology division and the founding of a new immunobiology graduate program.

 

Laboratory Research

The division has RO1, R21, PO1, and VA Merit awards of more than $2 million annually. Key research laboratories include that of Fred Finkelman, MD, Wenhai Shao, MD.

Dr. Finkelman, McDonald Professor of Medicine and Professor of Pediatrics, has considerable expertise in cytokine biology and the use of mouse models to study immunobiology.

Dr. Finkelman's research interests include the regulation of Th2 cytokine responses and Th2 cytokine effects; the roles of TH2 cytokines in host protection against infectious agents; the roles of B cell membrane immunoglobulin in lymphocyte activation and tolerance; and the development of a novel method for measuring in vivo cytokine production.

Dr. Finkelman's lab has published more than 300 papers and he has been among the 100 most-cited immunologists during the past 20 years.

The lab specializes in the use and manipulation of in vivo mouse models to answer questions of biological importance about immunoregulation. His lab has been active in training young faculty members and has recently accepted its first clinical immunology fellow.

Dr. Shao has three projects going on in the lab: 1). Axl small molecule inhibitor targeted therapy in mouse model of lupus nephritis; 2). Ezh2 methyl transferase targeted therapy in mouse model of systemic lupus. 3). Differential role of TAM receptors in the development of lupus and lupus nephritis. Since joining UC his research has been supported by a K01 grant from NIDDK. During his time as UC faculty, he has submitted extramural grant proposals to the US Department of Defense (DOD), NIDDK (NIH), the Lupus Research Alliance (LRA) and Kymera Therapeutics, LLC, as well as an intramural COM innovative and Department Junior Faculty Award. Recently, his research project was awarded an R01 from NIDDK/NIH. Currently, he has two grants pending at the DOD and the LRA, respectively.

 

Doctor at computer

More Information

Academic Office:
University of Cincinnati | Division of Immunology, Allergy and Rheumatology
231 Albert Sabin Way, MSB 7501
Mail Location #0563
Cincinnati, OH 45267-0563

Phone: 513-558-4701
Fax: 513-558-3799

Division Director:
Avis Ware, MD

Business Administrator:
Greg Taulbee
513-558-4701
taulbegw@ucmail.uc.edu