Today is Monday, Sep. 21, 2020

Coronavirus COVID-19 Updates: uc.edu/publichealth

Department of

Environmental and Public Health Sciences

Photo of  Long (Jason) Lu, PhD

Long (Jason) Lu, PhD

Associate Professor

Research Interests

Biomedical Informatics

Education/Credentials
  • Bachelor's Degree: Peking University
  • Doctoral Degree: Washington University School of Medicine
  • Postdoctorate: Yale University
Contact Information
  • Cincinnati Children's Hospital Medical Center
  • 3333 Burnett Avenue
  • Cincinnati, Ohio 45229
  • Office 513-636-8720
  • Email long.lu@cchmc.org

Peer Reviewed Publications

Chen Y.;Mazlack L.;Minai A.;Lu L. 12-01-2015. Inferring causal networks using fuzzy cognitive maps and evolutionary algorithms with application to Applied Soft Computing Journal, 37 , 667-679

Ren S.;Hinzman A.A.;Kang E.L.;Szczesniak R.D.;Lu L.J. 12-01-2015. Computational and statistical analysis of metabolomics data Metabolomics, 11 6, 1492-1513

Tan L.;Holland S.;Deshpande A.;Chen Y.;Choo D.;Lu L. 12-01-2015. A semi-supervised Support Vector Machine model for predicting the language outcomes following cochle Brain and Behavior, 5 12, 1-25

Chen Y.;Mazlack L.;Lu L. 12-01-2012. Inferring fuzzy cognitive map models for gene regulatory networks from gene expression data Proceedings - 2012 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2012, , 598-601

Zhang M.;Fang C.;Xu Y.;Bhatnagar R.;Lu L. 12-01-2010. An Integrative scoring approach to identify transcriptional regulations controlling lung surfactant Proceedings - IEEE International Conference on Data Mining, ICDM, , 787-792

Kim P.;Lu L.;Xia Y.;Gerstein M. 12-01-2006. Relating three-dimensional structures to protein networks provides evolutionary insights Science, 314 5807, 1938-1941

Tan L.;Chen Y.;Maloney T.;Caré M.;Holland S.;Lu L. 11-11-2013. Combined analysis of sMRI and fMRI imaging data provides accurate disease markers for hearing impair NeuroImage: Clinical, 3 , 416-428

Swertfeger D.;Rebholz S.;Li H.;Shah A.;Davidson W.;Lu L. 11-01-2018. Feasibility of a plasma bioassay to assess oxidative protection of low-density lipoproteins by high- Journal of Clinical Lipidology, 12 6, 1539-1548

Gordon S.;Deng J.;Tomann A.;Shah A.;Lu L.;Davidson W. 11-01-2013. Multi-dimensional co-separation analysis reveals protein-protein interactions defining plasma lipopr Molecular and Cellular Proteomics, 12 11, 3123-3134

Chen Y.;Mazlack L.;Lu L. 10-26-2012. Fuzzy cognitive maps development using ant colony optimization with local search procedure 2012 Annual Meeting of the North American Fuzzy Information Processing Society, NAFIPS 2012, ,

Tan L, Holland SK, Deshpande AK, Chen Y, Choo DI, Lu LJ. 10-2015. A semi-supervised Support Vector Machine model for predicting the language outcomes following cochlear implantation based on pre-implant brain fMRI imaging. Brain Behav., 5 12, e00391

He F.;Wen Y.;Deng J.;Lin X.;Lu L.;Jiao R.;Ma J. 10-14-2008. Probing Intrinsic Properties of a Robust Morphogen Gradient in Drosophila Developmental Cell, 15 4, 558-567

Feng X.;Krishnan K.;Richie D.;Aimanianda V.;Hartl L.;Grahl N.;Powers-Fletcher M.;Zhang M.;Fuller K.;Nierman W.;Lu L.;Latgé J.;Woollett L.;Newman S.;Cramer R.;Rhodes J.;Askew D. 10-01-2011. Haca-independent functions of the ER stress sensor irea synergize with the canonical UPR to influenc PLoS Pathogens, 7 10,

Gordon S.;Deng J.;Lu L.;Davidson W. 10-01-2010. Proteomic characterization of human plasma high density lipoprotein fractionated by gel filtration c Journal of Proteome Research, 9 10, 5239-5249

Huang Y.J.;Hang D.;Lu L.J.;Tong L.;Gerstein M.B.;Montelione G.T. 10-01-2008. Targeting the human cancer pathway protein interaction network by structural genomics Molecular and Cellular Proteomics, 7 10, 2048-2060

Gordon SM, Li H, Zhu X, Tso P, Reardon CA, Shah AS, Lu LJ, Davidson WS. 09-2012. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipoproteome. J Proteomics., 146 , 184

Zhang M.;Lu L. 09-16-2010. Investigating the validity of current network analysis on static conglomerate networks by protein ne BMC Bioinformatics, 11 ,

Deng J.;Wang W.;Lu L.;Ma J. 09-10-2010. A two-dimensional simulation model of the bicoid gradient in Drosophila PLoS ONE, 5 4,

Tan L.;Guo X.;Ren S.;Epstein J.N.;Lu L.J. 09-08-2017. A computational model for the automatic diagnosis of attention deficit hyperactivity disorder based Frontiers in Computational Neuroscience, 11 ,

Gordon S.;Li H.;Zhu X.;Tso P.;Reardon C.;Shah A.;Lu L.;Davidson W. 09-02-2016. Impact of genetic deletion of platform apolipoproteins on the size distribution of the murine lipopr Journal of Proteomics, 146 , 184-194

Ren J.;Jegga A.;Zhang M.;Deng J.;Liu J.;Gordon C.;Aronow B.;Lu L.;Zhang B.;Ma J. 09-01-2011. A Drosophila model of the neurodegenerative disease SCA17 reveals a role of RBJ-J/Su(H) in modulatin Human Molecular Genetics, 20 17, 3424-3436

Guo X.;Dominick K.C.;Minai A.A.;Li H.;Erickson C.A.;Lu L.J. 08-21-2017. Diagnosing autism spectrum disorder from brain resting-state functional connectivity patterns using Frontiers in Neuroscience, 11 AUG,

Cai WF, Liu GS, Lam CK, Florea S, Qian J, Zhao W, Pritchard T, Haghighi K, Lebeche D, Lu LJ, Deng J, Fan GC, Hajjar RJ, Kranias EG. 08-2015. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regulation of protein phosphatase inhibitor-1 and depressed contractility. Eur J Heart Fail., 17 8, 782

Li H, Gordon SM, Zhu X, Deng J, Swertfeger DK, Davidson WS, Lu LJ. 08-2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipoprotein Complexes. J Proteome Res., 14 8, 3082

Li H.;Gordon S.;Zhu X.;Deng J.;Swertfeger D.;Davidson W.;Lu L. 08-07-2015. Network-Based Analysis on Orthogonal Separation of Human Plasma Uncovers Distinct High Density Lipop Journal of Proteome Research, 14 8, 3082-3094

He F.;Wen Y.;Cheung D.;Deng J.;Lu L.;Jiao R.;Ma J. 08-05-2010. Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos BMC Developmental Biology, 10 ,

Cai W.;Liu G.;Lam C.;Florea S.;Qian J.;Zhao W.;Pritchard T.;Haghighi K.;Lebeche D.;Lu L.;Deng J.;Fan G.;Hajjar R.;Kranias E. 08-01-2015. Up-regulation of micro-RNA765 in human failing hearts is associated with post-transcriptional regula European Journal of Heart Failure, 17 8, 782-793

Gordon S.;Davidson W.;Urbina E.;Dolan L.;Heink A.;Zang H.;Lu L.;Shah A. 08-01-2013. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth Diabetes, 62 8, 2958-2967

Wu L.;Hwang S.I.;Rezaul K.;Lu L.J.;Mayya V.;Gerstein M.;Eng J.K.;Lundgren D.H.;Han D.K. 08-01-2007. Global survey of human T leukemic cells by integrating proteomics and transcriptomics profiling Molecular and Cellular Proteomics, 6 8, 1343-1353

Lu Y.;Lu Y.;Deng J.;Peng H.;Lu H.;Lu L.J. 07-31-2015. A novel essential domain perspective for exploring gene essentiality Bioinformatics, 31 18, 2921-2929

Xu Y.;Zhang M.;Wang Y.;Kadambi P.;Dave V.;Lu L.;Whitsett J. 07-26-2010. A systems approach to mapping transcriptional networks controlling surfactant homeostasis BMC Genomics, 11 1,

Zhang M.;Su S.;Bhatnagar R.;Hassett D.;Lu L. 07-24-2012. Prediction and analysis of the protein interactome in Pseudomonas aeruginosa to enable network-based PLoS ONE, 7 7,

Deshpande AK, Tan L, Lu LJ, Altaye M, Holland SK. 07-2016. fMRI as a Preimplant Objective Tool to Predict Postimplant Oral Language Outcomes in Children with Cochlear Implants. Ear Hear., 37 4, e263

Zhang M.;Deng J.;Fang C.;Zhang X.;Lu L. 07-07-2010. Molecular Network Analysis and Applications Knowledge-Based Bioinformatics: From Analysis to Interpretation, , 251-287

Heink A.;Davidson W.;Swertfeger D.;Lu L.;Shah A. 07-02-2015. A Comparison of Methods to Enhance Protein Detection of Lipoproteins by Mass Spectrometry Journal of Proteome Research, 14 7, 2943-2950

Deshpande A.;Tan L.;Lu L.;Altaye M.;Holland S. 07-01-2016. FMRI as a Preimplant Objective Tool to Predict Postimplant Oral Language Outcomes in Children with C Ear and Hearing, 37 4, e263-e272

Gordon S.;Davidson W.;Urbina E.;Dolan L.;Heink A.;Zang H.;Lu L.;Shah A. 07-01-2016. Erratum: The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male yo Diabetes, 65 7, 2100

Lu L.J.;Sboner A.;Huang Y.J.;Lu H.X.;Gianoulis T.A.;Yip K.Y.;Kim P.M.;Montelione G.T.;Gerstein M.B. 07-01-2007. Comparing classical pathways and modern networks: towards the development of an edge ontology Trends in Biochemical Sciences, 32 7, 320-331

Lu L.;Xia Y.;Paccanaro A.;Yu H.;Gerstein M. 07-01-2005. Assessing the limits of genomic data integration for predicting protein networks Genome Research, 15 7, 945-953

Guo X.;Minai A.;Lu L. 06-30-2017. Feature selection using multiple auto-encoders Proceedings of the International Joint Conference on Neural Networks, 2017-May , 4602-4609

Lu L.;Xia Y.;Yu H.;Rives A.;Lu H.;Schubert F.;Gerstein M. 06-15-2005. Protein Interaction Prediction by Integrating Genomic Features and Protein Interaction Network Analy Data Analysis and Visualization in Genomics and Proteomics, , 61-81

Zhang M.;Zhu C.;Jacomy A.;Lu L.;Jegga A. 06-10-2011. The orphan disease networks American Journal of Human Genetics, 88 6, 755-766

Gordon S.;Li H.;Zhu X.;Shah A.;Lu L.;Davidson W. 06-05-2015. A comparison of the mouse and human lipoproteome: Suitability of the mouse model for studies of huma Journal of Proteome Research, 14 6, 2686-2695

Panmanee W.;Su S.;Schurr M.;Lau G.;Zhu X.;Ren Z.;McDaniel C.;Lu L.;Ohman D.;Muruve D.;Panos R.;Yu H.;Thompson T.;Tseng B.;Hassett D. 06-01-2019. The anti-sigma factor MucA of Pseudomonas aeruginosa: Dramatic differences of a mucA22 vs. A ?mucA m PLoS ONE, 14 6,

Flores S.;Lu L.;Yang J.;Carriero N.;Gerstein M. 05-22-2007. Hinge Atlas: Relating protein sequence to sites of structural flexibility BMC Bioinformatics, 8 ,

Deshpande A.;Tan L.;Lu L.;Altaye M.;Holland S. 05-01-2018. fMRI as a preimplant objective tool to predict children's postimplant auditory and language outcomes Journal of the American Academy of Audiology, 29 5, 389-404

Swertfeger D.;Li H.;Rebholz S.;Zhu X.;Shah A.;Davidson W.;Lu L. 04-01-2017. Mapping atheroprotective functions and related proteins/lipoproteins in size fractionated human plas Molecular and Cellular Proteomics, 16 4, 680-693

Xia Y.;Lu L.J.;Gerstein M. 03-17-2006. Integrated prediction of the helical membrane protein interactome in yeast Journal of Molecular Biology, 357 1, 339-349

Deng J.;Su S.;Lin X.;Hassett D.;Lu L. 03-08-2013. A Statistical Framework for Improving Genomic Annotations of Prokaryotic Essential Genes PLoS ONE, 8 3,

Krishnan K.;Ren Z.;Losada L.;Nierman W.;Lu L.;Askew D. 02-25-2014. Polysome profiling reveals broad translatome remodeling during endoplasmic reticulum (ER) stress in BMC Genomics, 15 1,

Brewington J.J.;Backstrom J.;Feldman A.;Kramer E.L.;Moncivaiz J.D.;Ostmann A.J.;Zhu X.;Lu L.J.;Clancy J.P. 02-22-2018. Chronic ?2AR stimulation limits CFTR activation in human airway epithelia JCI insight, 3 4,

Chen Y.;Storrs J.;Tan L.;Mazlack L.;Lee J.;Lu L. 01-15-2014. Detecting brain structural changes as biomarker from magnetic resonance images using a local feature Journal of Neuroscience Methods, 221 , 22-31

Zhu X.;Shah A.S.;Swertfeger D.K.;Li H.;Ren S.;Melchior J.T.;Gordon S.M.;Davidson W.S.;Lu L.J. 01-01-2018. High-density lipoproteins-associated proteins and subspecies related to arterial stiffness in young Complexity, 2018 ,

Melchior J.;Street S.;Andraski A.;Furtado J.;Sacks F.;Shute R.;Greve E.;Swertfeger D.;Li H.;Shah A.;Lu L.;Davidson W. 01-01-2017. Apolipoprotein A-II alters the proteome of human lipoproteins and enhances cholesterol efflux from A Journal of Lipid Research, 58 7, 1374-1385

Lu L. 01-01-2015. Preface. Gene essentiality Methods in molecular biology (Clifton, N.J.), 1279 , v

Lu Y.;Lu Y.;Deng J.;Lu H.;Lu L.J. 01-01-2015. Discovering essential domains in essential genes Methods in Molecular Biology, 1279 , 235-245

Lu Y.;Deng J.;Carson M.;Lu H.;Lu L. 01-01-2014. Computational methods for the prediction of microbial essential genes Current Bioinformatics, 9 2, 89-101

Lu Y.;Deng J.;Rhodes J.;Lu H.;Lu L. 01-01-2014. Predicting essential genes for identifying potential drug targets in Aspergillus fumigatus Computational Biology and Chemistry, 50 , 29-40

Deng J.;Tan L.;Lin X.;Lu Y.;Lu L. 01-01-2012. Exploring the optimal strategy to predict essential genes in microbes Biomolecules, 2 1, 1-22

Deng J.;Deng L.;Su S.;Zhang M.;Lin X.;Wei L.;Minai A.;Hassett D.;Lu L. 01-01-2011. Investigating the predictability of essential genes across distantly related organisms using an inte Nucleic Acids Research, 39 3, 795-807