Today is Monday, Sep. 21, 2020

Department of Environmental and Public Health Sciences

Risk Science Center (RSC)

Coronavirus COVID-19 Updates: uc.edu/publichealth

News & Events

  • SOT Virtual Session 
    Dr. Lynne Haber will present in a Society for Toxicology (SOT) Virtual Annual Meeting on latest guidance for chemical dose response assessment. With the cancellation of the Society of Toxicology (SOT) meeting in March, each SOT Specialty Section selected a session to deliver as a webinar. The Food Safety Specialty Section is hosting the following session on Tuesday, April 21 from noon to 2:45 PM (ET).

    Globally Harmonized Guidance for Dose-Response Analysis and Derivation of Health-Based Guidance Values for Chemicals in Food

    The event is free and open to members and nonmembers. Register HERE. Dr. Haber will introduce available Benchmark Dose Modeling platforms. She will address the need for global harmonization with case studies and present a new consensus decision tree, designed to aid in harmonizing approaches and be a practical guide to risk assessors and managers by illustrating how key decision points are affected by a variety of practical scenarios.

    For a full schedule of the SOT Virtual Meeting offerings, see: https://www.toxicology.org/events/am/AM2020/program.asp

  • SOT Virtual Poster
    Dr. Brian Palmer is presenting a poster in the SOT Virtual Poster Session. 

    3291: Poster Board - P104: Dosimetric Modeling of Inhaled Multiwalled Carbon Nanotubes for Use in Risk Assessment. B. C. Palmer1, J. Matheson2, and L. T. Haber1. 1University of Cincinnati, Cincinnati, OH; and 2Consumer Product Safety Commission, Bethesda, MD.

    View the poster HERE, Email Dr. Palmer at palmerbc@ucmail.uc.edu to discuss the findings.

  • Future Risk Assessment and Communication Workshop
    The RSC and UC ERC, in collaboration with Cardno Chemrisk, SafeDose, and RiskPartners.ca, have been planning our next Workshop on Assessing and Communicating Risks for Toxicologists and Risk Assessors, to be held when it is again safe to travel. Interested? Email risksciencecenter@uc.edu and we will keep you posted on the latest developments.  This two-part continuing education workshop is intended for new and veteran risk assessors. Two days will be focused on risk assessment, with an emphasis on hazard and dose response assessment, and two days on risk communication. Both parts are highly interactive. 

  • The International Toxicity Estimates for Risk (ITER) database is currently unavailable.  The National Library of Medicine is moving the toxicological resources found on TOXNET to new homes and ITER will be reformatted for inclusion on NLM’s Bookshelf.  See https://www.nlm.nih.gov/toxnet/index.html. 

  • Jacqueline Patterson of the Risk Science Center was elected a Fellow of the Society for Risk Analysis (SRA) at the December 2019 SRA Annual Meeting.  The SRA is a multidisciplinary, interdisciplinary, scholarly, international society that provides an open forum for all those who are interested in risk analysis. Congratulations Jacqueline!
  • A Risk Science Center project was featured in a podcast by the journal Integrated Environmental Management and Assessment. Alison Pecquet discussed her recent publication on polymers in cleaning products and data gaps for environmental risk assessment. The purpose of this study was to identify, characterize, and assess data needs for ecological risk of household cleaning product polymers currently being used in the United States.  Listen Here: https://ieampodcast.com/2019/09/03/cleaning-products-the-fine-print-with-alison-pecquet/  Pecquet, A.M., Pittinger, C.A., McAvoy, D.C. (2019). Survey of Polymers Used in Cleaning Products: Categorization, Data Availability, and Prioritization of Polymers for Ecological Risk Assessment. Integrated Environmental Assessment and Management, 15(4):621-632.
  • Dr. Lynne Haber was a coauthor, together with scientists from the US EPA, EFSA, and other groups around the world, of the update of Chapter 5 (dose-response assessment) of WHO EHC 240. A key element of the update relates to methods for benchmark dose (BMD) modeling. The public comment draft can be accessed at https://www.who.int/news-room/articles-detail/public-consultation-on-the-jecfa-jmpr-update-of-chapter-5-(ehc-240) and the deadline for comments is January 31, 2020. Dr. Haber is also part of the team presenting about the updates at the SRA annual meeting and the upcoming SOT annual meeting.
  • A recent publication describes a Risk Science Center project on a meta-regression of 55 studies (2652 subjects) to evaluate the impact of dietary cholesterol on serum LDL and HDL:  Vincent, M.J., B. Allen, O.M. Palacios, L.T. Haber, and K.C. Maki. 2019. Meta-regression analysis of the effects of dietary cholesterol intake on low- and high-density lipoprotein cholesterol. Am. J. Clin. Nutr. 109:7-16. doi: 10.1093/ajcn/nqy273
  • In a collaborative project with the Army Corp and Neutral Science, the RSC developed a technical report that informs product development decisions using NanoGRID by facilitating consideration of whether risk characterization is feasible for a given choice of product composition without substantial investment in analytical methods development, with the goal of clarifying risk management uncertainty for product development. L.T. Haber, A.J. Bednar, A.J. Kennedy, M.L. Ballentine, and R.A. Canady. 2019. Methods Evaluation for Assessing Release of Manufactured Nanomaterials from Polymers, Consistent with the NanoGRID Framework. Prepared for Army Corp of Engineers/ERDC. No. ERDC/EL TR-19-6
  • Vincent, M.J., B. Allen, O.M. Palacios, L.T. Haber, and K.C. Maki. 2019 Meta-regression analysis of the effects of dietary cholesterol intake on low- and high-density lipoprotein cholesterol. Am. J. Clin. Nutr. 109:7-16. doi: 10.1093/ajcn/nqy273. A meta-regression of 55 studies (2652 subjects) to evaluate the impact of dietary cholesterol on serum LDL and HDL.
  • Frank, E., LT Haber, MB Genter, and A Maier. 2018. Defining molecular initiating events of airway sensory irritation in support of predictive testing approaches. Applied In vitro Toxicology. 4:317-331. https://doi.org/10.1089/aivt.2018.0007. Sensory irritation is an important endpoint for inhalation exposure limits, but current testing methods are inadequate for identifying sensory irritants and effect levels. This paper uses an AOP approach to identify MIEs that could be used as the basis for an in vitro assay.
  • Haber, LT; ML Dourson, BC Allen, R Hertzberg, A Parker, MJ Vincent, A Maier, and AR Boobis. 2018. Benchmark Dose (BMD) Modeling: Current practice, issues and challenges. Crit Rev. Toxicol. https://doi.org/10.1080/10408444.2018.1430121 8:1-29. Methods for modeling are reviewed, together with key disagreements between EPA and EFSA guidance, including examples of the practical implications of the areas of difference. 
  • Felter, SP; JE Foreman, A Boobis, JC Corton, AM Doi, L Flowers, J Goodman, LT Haber, A Jacobs, JE Klaunig, A Lynch, J Moggs, A Pandiri. 2018. Human Relevance of Rodent Liver Tumors: Key Insights from a Toxicology Forum Workshop on Nongenotoxic Modes of Action. Regul Toxicol Pharmacol. 92:1-7. doi: 10.1016/j.yrtph.2017.11.003. The state of the science was reviewed regarding two nuclear receptor-mediated MOAs (Constitutive Androstane Receptor (CAR) and Peroxisome Proliferator Activated Receptor-alpha (PPARα), and cytotoxicity. 
  • Haber, L.T., H.K. Bates, B.C. Allen, M.J. Vincent, and A.R. Oller. 2017. Derivation of an oral toxicity reference value for nickel. Regul. Toxicol Pharmacol. 87 Suppl 1:S1-S18. doi: 10.1016/j.yrtph.2017.03.011. This paper derives toxicity reference values (TRVs) for three populations of interest: adults, toddlers, and people who have been dermally sensitized to nickel.
  • Registration is now open for the Risk Workshop for Toxicologists and Risk Assessors being held in Vancouver, British Columbia in November 2019. A 2-day risk assessment course (November 5-6) will be followed by a second 2-day course on risk communication (November 7-8). Dr. Lynne Haber of the Risk Science Center will be an instructor in the risk assessment course. These courses are being put on by the Society of Toxicology Canada. See details and register at https://riskworkshop2019.wixsite.com/stcriskworkshop2019.
  • Society for Risk Analysis workshop - Fundamentals of the Risk Assessment Paradigm, From Hazard Characterization to Risk Communication, with an Emphasis on Contaminated Sites. Dr. Lynne Haber will be an instructor in this all day workshop on Sunday, December 8 in Arlington, Virginia. The workshop is intended for entry- to mid-level risk assessors and will provide site assessors with an improved understanding of key issues underlying environmental standards, as well as provide toxicological risk assessors with improved understanding of real-world challenges in applying toxicity factors and interpreting risk estimates. More details and to register: http://srameetings.wpengine.com/programs/workshops/
  • New chemical risk information from IARC ( International Agency for Research on Carcinogenicity) has been added to the International Toxicity Estimates for Risk (ITER) database. See the latest list of additions and changes at https://med.uc.edu/eh/centers/rsc/risk-resources/chemical-toxicity-values-iter. Access ITER via National Library of Medicine’s TOXNET - https://toxnet.nlm.nih.gov/newtoxnet/iter.htm.
  • Dr Brian Palmer has joined the Risk Science Center as a post-doctoral fellow.Dr. Palmer earned his PhD in toxicology from the University of Rochester where he researched the dermal toxicity of engineered nanomaterials (e.g. carbon nanotubes, silica nanoparticles, and titanium dioxide nanoparticles) in a mouse model of allergic contact dermatitis. He can be reached at brian.palmer@uc.edu.