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ASPET Summer Undergraduate Research Fellowships

Photo of  Georg Weber, MD,PhD

Georg Weber, MD,PhD

Associate Professor

Contact Information
  • UC College of Pharmacy
  • 231 Albert Sabin Way, MSB
  • Cincinnati, Ohio 45267
  • Office 513-558-0947
  • Email Georg.Weber@uc.edu
  • UC Institute Member Seal

Peer Reviewed Publications

Alsarkhi, Lamyaa Kadhim; Weber, Georg F 2018. Anti?osteopontin autoantibodies in various types of cancer. Oncology reports, 40 6, 3879-3889

Walaszek, Kinga; Lower, Elyse E; Ziolkowski, Piotr; Weber, Georg F 2018. Breast cancer risk in premalignant lesions: osteopontin splice variants indicate prognosis. British journal of cancer, 119 10, 1259-1266

Weber, Georg F 2018. The Phylogeny of Osteopontin-Analysis of the Protein Sequence. International journal of molecular sciences, 19 9,

Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Aparicio-Bautista, Diana Ivette; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Osteopontin splice variants and polymorphisms in cancer progression and prognosis. Biochimica et biophysica acta. Reviews on cancer, 1868 1, 93-108.A

Briones-Orta, Marco Antonio; Avendaño-Vázquez, S Eréndira; Ivette Aparicio-Bautista, Diana; Coombes, Jason D; Weber, Georg F; Syn, Wing-Kin 2017. Prediction of transcription factor bindings sites affected by SNPs located at the osteopontin promoter. Data in brief, 14 , 538-542

Hartung, Franz; Wang, Yunguan; Aronow, Bruce; Weber, Georg F 2017. A core program of gene expression characterizes cancer metastases. Oncotarget, 8 60, 102161-102175

Ramchandani, Divya; Unruh, Dusten; Lewis, Clayton S; Bogdanov, Vladimir Y; Weber, Georg F 2016. Activation of carbonic anhydrase IX by alternatively spliced tissue factor under late-stage tumor conditions. Laboratory investigation; a journal of technical methods and pathology, 96 12, 1234-1245

Unruh D, Ünlu B, Lewis CS, Qi X, Chu Z, Sturm R, Keil R, Ahmad SA, Sovershaev T, Adam M, Van Dreden P, Woodhams BJ, Ramchandani D, Weber GF, Rak JW, Wolberg AS, Mackman N, Versteeg HH, Bogdanov VY 2016. Antibody-based targeting of alternatively spliced Tissue Factor: a new approach to impede the primary growth and aggressiveness of pancreatic ductal adenocarcinoma. Oncotarget, ,

Unruh, Dusten; Ünlü, Betül; Lewis, Clayton S; Qi, Xiaoyang; Chu, Zhengtao; Sturm, Robert; Keil, Ryan; Ahmad, Syed A; Sovershaev, Timofey; Adam, Mariette; Van Dreden, Patrick; Woodhams, Barry J; Ramchandani, Divya; Weber, Georg F; Rak, Janusz W; Wolberg, Alisa S; Mackman, Nigel; Versteeg, Henri H; Bogdanov, Vladimir Y 2016. Antibody-based targeting of alternatively spliced tissue factor: a new approach to impede the primary growth and spread of pancreatic ductal adenocarcinoma. Oncotarget, 7 18, 25264-75

Weber GF 2016. Metabolism in cancer metastasis International Journal of Cancer, ,

Weber, Georg F 2016. Time and Circumstances: Cancer Cell Metabolism at Various Stages of Disease Progression. Frontiers in oncology, 6 , 257

Weber, Georg F 2016. Metabolism in cancer metastasis. International journal of cancer, 138 9, 2061-6

Zduniak, Krzysztof; Agrawal, Anil; Agrawal, Siddarth; Hossain, Md Monir; Ziolkowski, Piotr; Weber, Georg F 2016. Osteopontin splice variants are differential predictors of breast cancer treatment responses. BMC cancer, 16 , 441

Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for cancer BBA Reviews on Cancer, 1855 , 202-222

Ramchandani D, Weber GF 2015. Interactions between OPN and VEGF in health and disease. Implications for the skeletal system Bone, 81 , 7-15

Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for skeletal disorders. Bone, 81 , 7-15

Ramchandani, Divya; Weber, Georg F 2015. Interactions between osteopontin and vascular endothelial growth factor: Implications for cancer. Biochimica et biophysica acta, 1855 2, 202-22

Weber GF 2015. Somnambulism and allergy Clinical and Experimental Neuroimmunology , 6 , 321

Weber GF 2015. Molecular analysis of a recurrent sarcoma identifies a mutation in FAF1 Sarcoma, 839182 , doi:10.1155/2015/839182

Weber, Georg F 2015. Molecular Analysis of a Recurrent Sarcoma Identifies a Mutation in FAF1. Sarcoma, 2015 , 839182

Zduniak K, Ziolkowski P, Ahlin C, Agrawal A, Agrawal S, Blomqvist C, Fjällskog ML, Weber GF 2015. Nuclear Osteopontin-c is a marker for breast cancer prognosis British Journal of Cancer , 112 , 729-738

Zduniak, K; Ziolkowski, P; Ahlin, C; Agrawal, A; Agrawal, S; Blomqvist, C; Fjällskog, M-L; Weber, G F 2015. Nuclear osteopontin-c is a prognostic breast cancer marker. British journal of cancer, 112 4, 729-38

Shen H, Weber GF 2014. The osteopontin-c splice junction is important for anchorage-independent growth Molecular Carcinogenesis, 53 , 480-487

Shi Z, Mirza M, Wang B, Kennedy MA, Weber GF 2014. Osteopontin-a alters glucose homeostasis in anchorage-independent breast cancer cells Cancer Letters, 344 , 47-53

Shi Z, Wang B, Kennedy MA, Weber GF 2014. Metabolic skewing during anchorage independence. Induction by osteopontin-c PlosOne, 9 , e105675

Shi, Zhanquan; Wang, Bo; Chihanga, Tafadzwa; Kennedy, Michael A; Weber, Georg F 2014. Energy metabolism during anchorage-independence. Induction by osteopontin-c. PloS one, 9 8, e105675

Weber GF, Johnson BN, Yamamoto BK, Gudelsky GA 2014. Effects of stress and MDMA on hippocampal gene expression BioMed Research International, 2014 , 141396

Hartung F, Weber GF 2013. RNA blood levels of osteopontin splice variants are cancer markers SpringerPlus, 2 , 110

Milanowski P, Carter TJ, Weber GF 2013. Enzyme catalysis and the outcome of biochemical reactions Journal of Proteomics and Bioinformatics , 6 , 132-141

Ramchandani D, Weber GF 2013. An osteopontin promoter polymorphism is associated with aggressiveness in breast cancer Oncology Reports, 30 , 1860-1868

Wang B, Shi Z, Weber GF, Kennedy MA 2013. Introduction of a new critical p value correction method for statistical significance analysis of metabonomics data Analytical and Bioanalytical Chemistry, 405 , 8419-8429

Weber GF 2013. Gene therapy--why can it fail? Medical Hypotheses, 80 , 613-616

Weber GF 2013. Dynamic knowledge - a century of evolution Sociology Mind , 3 , 268-277

Weber, Georg F 2013. Why does cancer therapy lack effective anti-metastasis drugs? Cancer letters, 328 2, 207-11

Weber GF 2012. Why does cancer therapy lack effective anti-metastasis drugs? Cancer Letters, 328 , 207-211

Weber GF, Warren J, Shoma H, Chen T, Halim A, Chakravarty G 2012. Biomarkers - A pot of gold or a can of worms? Meeting report from the 2nd world congress on biomarkers in clinical research, 2011, Baltimore, USA Cancer Biology & Therapy , 13 , 831-835

Tilli TM, Franco VF, Robbs BK, Wanderley JL, Silva F, Duarte de Mello K, Viola JPB, Weber GF, Gimba ERP 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression Molecular Cancer Research , 9 , 280-293

Tilli, Tatiana M; Franco, Vanessa Ferreira; Robbs, Bruno Kaufmann; Wanderley, João Luiz Mendes; da Silva, Fabrício Ribeiro de Azevedo; de Mello, Kivvi Duarte; Viola, João P B; Weber, Georg F; Gimba, Etel R 2011. Osteopontin-c splicing isoform contributes to ovarian cancer progression. Molecular cancer research : MCR, 9 3, 280-93

Weber GF 2011. The cancer biomarker Osteopontin: Combination with other markers Cancer Genomics and Proteomics, 8 , 263-288

Weber GF, Lett GS, Haubein NC 2011. Categorical meta-analysis of Osteopontin as a clinical cancer marker Oncology Reports, 25 , 433-441

Zhang R, Pan X, Huang Z, Weber GF, Zhang G 2011. Osteopontin enhances the expression and activity of MMP-2 via the SDF-1/CXCR4 axis in hepatocellular carcinoma cell lines PloS one, 6 , e23831

Weber GF 2010. Molecular genetics and metastasis Encyclopedia of Life Sciences, , DOI 10.1002/9780470015902.a0022447

Weber GF 2010. Toward a molecular classification of cancer Biomarker Theme Issue of Toxicology, 278 , 195-198

Weber GF, Lett GS, Haubein NC 2010. Osteopontin is a marker for cancer aggressiveness and patient survival British Journal of Cancer , 103 , 861-869

Weber, G F; Lett, G S; Haubein, N C 2010. Osteopontin is a marker for cancer aggressiveness and patient survival. British journal of cancer, 103 6, 861-9

Weber, Georg F 2010. Toward a molecular classification of cancer. Toxicology, 278 2, 195-8

Sullivan J, Blair L, Alnajar A, Aziz T, Ng CY, Chipitsyna G, Gong Q, Witkiewicz A, Weber GF, Denhardt DT, Yeo CJ, Arafat HA. 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma Surgery, 146 , 232-240

Sullivan, Jennifer; Blair, Laurel; Alnajar, Amer; Aziz, Tamer; Ng, Chee Yuan; Chipitsyna, Galina; Gong, Qiaoke; Witkiewicz, Agnes; Weber, Georg F; Denhardt, David T; Yeo, Charles J; Arafat, Hwyda A 2009. Expression of a prometastatic splice variant of osteopontin, OPNC, in human pancreatic ductal adenocarcinoma. Surgery, 146 2, 232-40

Weber GF 2009. Drug targets in cancer metastasis American Association for Cancer Research 100th Annual Meeting Education Book, , 137-140

Mirza M, Shaughnessy E, Hurley JK, Vanpatten KA, Pestano GA, He B, Weber GF 2008. Osteopontin-c is a highly selective marker for breast cancer International Journal of Cancer , 122 , 889-897

Mirza, Mana; Shaughnessy, Elizabeth; Hurley, John K; Vanpatten, Kristie A; Pestano, Gary A; He, Bin; Weber, Georg F 2008. Osteopontin-c is a selective marker of breast cancer. International journal of cancer, 122 4, 889-97

Syed M, Fenoglio-Preiser C, Skau KA, Weber GF 2008. Acetylcholinesterase supports anchorage independence in colon cancer Clinical and Experimental Metastasis, 25 , 787-798

Syed, Moyeenuddin; Fenoglio-Preiser, Cecilia; Skau, Kenneth A; Weber, Georg F 2008. Acetylcholinesterase supports anchorage independence in colon cancer. Clinical & experimental metastasis, 25 7, 787-98

Weber GF 2008. Molecular mechanisms of metastasis Cancer Letters, 270 , 181-190

Whalen KA, Weber GF, Benjamin TL, Schaffhausen BS 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for migration of transformed cells The Journal of Virology, 82 , 4946-4954

Whalen, Kerry A; Weber, Georg F; Benjamin, Thomas L; Schaffhausen, Brian S 2008. Polyomavirus middle T antigen induces the transcription of osteopontin, a gene important for the migration of transformed cells. Journal of virology, 82 10, 4946-54

He B, Mirza M, Weber GF 2006. An osteopontin splice variant induces anchorage independence in human breast cancer cells Oncogene, 25 , 2192-2202

Mesa C Jr, Mirza M, Mitsutake N, Sartor M, Medvedovic M, Tomlinson C, Knauf JA, Weber GF, Fagin JA 2006. Conditional activation of RET/PTC3 and BRAFV600E in thyroid cells is associated with gene expression profiles that predict a preferential role of BRAF in extracellular matrix remodeling Cancer Research, 66 , 6521-6529

Craig-Mylius C, Weber GF, Coburn JL, Glickstein LG 2005. Borrelia burgdorferi, an extracellular pathogen, circumvents osteopontin in inducing an inflammatory cytokine response Journal of Leukocyte Biology, 77 , 710-718

He B, Weber GF 2004. Synergistic activation of the CMV promoter by NF-kB P50 and Cyclic GMP-Dependent Kinase Biochemical and Biophysical Research Communications , 321 , 13-20

Weber GF 2004. The absence of CD44 ameliorates Faslpr/lpr disease Autoimmunity , 37 , 1-8

Weber, Georg F . The cancer biomarker osteopontin: combination with other markers. Cancer genomics & proteomics, 8 6, 263-88