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ASPET Summer Undergraduate Research Fellowships

Photo of  David Hildeman, PhD

David Hildeman, PhD

Associate Professor of Pediatrics-Division of Immunobiology and Director of the Immunobiology Graduate Program

Research Interests

The overall goal of the Hildeman laboratory is to investigate the apoptotic control of T cell homeostasis in health and disease.

Education/Credentials
  • Ph.D.: University of Wisconsin
  • Post Doc: National Jewish Hospital and Medical Center
Contact Information

Peer Reviewed Publications

Lampe, Kristin; Endale, Mehari; Cashman, Siobhan; Fang, Hao; Mattner, Jochen; Hildeman, David; Hoebe, Kasper 2015. Slp-76 is a critical determinant of NK-cell mediated recognition of missing-self targets. European journal of immunology, 45 7, 2072-83

Niss, Omar; Sholl, Allyson; Bleesing, Jack J; Hildeman, David A 2015. IL-10/Janus kinase/signal transducer and activator of transcription 3 signaling dysregulates Bim expression in autoimmune lymphoproliferative syndrome. The Journal of allergy and clinical immunology, 135 3, 762-70

Raynor, Jana; Karns, Rebekah; Almanan, Maha; Li, Kun-Po; Divanovic, Senad; Chougnet, Claire A; Hildeman, David A 2015. IL-6 and ICOS Antagonize Bim and Promote Regulatory T Cell Accrual with Age. Journal of immunology (Baltimore, Md. : 1950), 195 3, 944-52

Johnson, Theodore S; Terrell, Catherine E; Millen, Scott H; Katz, Jonathan D; Hildeman, David A; Jordan, Michael B 2014. Etoposide selectively ablates activated T cells to control the immunoregulatory disorder hemophagocytic lymphohistiocytosis. Journal of immunology (Baltimore, Md. : 1950), 192 1, 84-91

McNally, Jonathan P; Elfers, Eileen E; Terrell, Catherine E; Grunblatt, Eli; Hildeman, David A; Jordan, Michael B; Katz, Jonathan D 2014. Eliminating encephalitogenic T cells without undermining protective immunity. Journal of immunology (Baltimore, Md. : 1950), 192 1, 73-83

Currier, Mark A; Eshun, Francis K; Sholl, Allyson; Chernoguz, Artur; Crawford, Kelly; Divanovic, Senad; Boon, Louis; Goins, William F; Frischer, Jason S; Collins, Margaret H; Leddon, Jennifer L; Baird, William H; Haseley, Amy; Streby, Keri A; Wang, Pin-Yi; Hendrickson, Brett W; Brekken, Rolf A; Kaur, Balveen; Hildeman, David; Cripe, Timothy P 2013. VEGF blockade enables oncolytic cancer virotherapy in part by modulating intratumoral myeloid cells. Molecular therapy : the journal of the American Society of Gene Therapy, 21 5, 1014-23

Kurtulus, Sema; Hildeman, David 2013. Assessment of CD4(+) and CD8 (+) T cell responses using MHC class I and II tetramers. Methods in molecular biology (Clifton, N.J.), 979 , 71-9

Phelan, James D; Saba, Ingrid; Zeng, Hui; Kosan, Christian; Messer, Malynda S; Olsson, H Andre; Fraszczak, Jennifer; Hildeman, David A; Aronow, Bruce J; Möröy, Tarik; Grimes, H Leighton 2013. Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. PLoS genetics, 9 9, e1003713

Pierson, Wim; Cauwe, Bénédicte; Policheni, Antonia; Schlenner, Susan M; Franckaert, Dean; Berges, Julien; Humblet-Baron, Stephanie; Schönefeldt, Susann; Herold, Marco J; Hildeman, David; Strasser, Andreas; Bouillet, Philippe; Lu, Li-Fan; Matthys, Patrick; Freitas, Antonio A; Luther, Rita J; Weaver, Casey T; Dooley, James; Gray, Daniel H D; Liston, Adrian 2013. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3? regulatory T cells. Nature immunology, 14 9, 959-65

Raynor, Jana; Sholl, Allyson; Plas, David R; Bouillet, Philippe; Chougnet, Claire A; Hildeman, David A 2013. IL-15 Fosters Age-Driven Regulatory T Cell Accrual in the Face of Declining IL-2 Levels. Frontiers in immunology, 4 , 161

Sena, Laura A; Li, Sha; Jairaman, Amit; Prakriya, Murali; Ezponda, Teresa; Hildeman, David A; Wang, Chyung-Ru; Schumacker, Paul T; Licht, Jonathan D; Perlman, Harris; Bryce, Paul J; Chandel, Navdeep S 2013. Mitochondria are required for antigen-specific T cell activation through reactive oxygen species signaling. Immunity, 38 2, 225-36

Kurtulus, Sema; Tripathi, Pulak; Hildeman, David A 2012. Protecting and rescuing the effectors: roles of differentiation and survival in the control of memory T cell development. Frontiers in immunology, 3 , 404

Raynor, Jana; Lages, Celine S; Shehata, Hesham; Hildeman, David A; Chougnet, Claire A 2012. Homeostasis and function of regulatory T cells in aging. Current opinion in immunology, 24 4, 482-7

Chougnet, Claire A; Tripathi, Pulak; Lages, Celine S; Raynor, Jana; Sholl, Allyson; Fink, Pamela; Plas, David R; Hildeman, David A 2011. A major role for Bim in regulatory T cell homeostasis. Journal of immunology (Baltimore, Md. : 1950), 186 1, 156-63

Doetschman, Thomas; Sholl, Allyson; Chen, Hwu dau rw; Gard, Connie; Hildeman, David A; Bommireddy, Ramireddy 2011. Divergent effects of calcineurin A? on regulatory and conventional T-cell homeostasis. Clinical immunology (Orlando, Fla.), 138 3, 321-30

Guo, Fukun; Zhang, Shuangmin; Tripathi, Pulak; Mattner, Jochen; Phelan, James; Sproles, Alyssa; Mo, Jun; Wills-Karp, Marsha; Grimes, H Leighton; Hildeman, David; Zheng, Yi 2011. Distinct roles of Cdc42 in thymopoiesis and effector and memory T cell differentiation. PloS one, 6 3, e18002

Kurtulus, Sema; Tripathi, Pulak; Moreno-Fernandez, Maria E; Sholl, Allyson; Katz, Jonathan D; Grimes, H Leighton; Hildeman, David A 2011. Bcl-2 allows effector and memory CD8+ T cells to tolerate higher expression of Bim. Journal of immunology (Baltimore, Md. : 1950), 186 10, 5729-37

Barnes, Michael J; Aksoylar, Halil; Krebs, Philippe; Bourdeau, Tristan; Arnold, Carrie N; Xia, Yu; Khovananth, Kevin; Engel, Isaac; Sovath, Sosathya; Lampe, Kristin; Laws, Eleana; Saunders, Amy; Butcher, Geoffrey W; Kronenberg, Mitchell; Steinbrecher, Kris; Hildeman, David; Grimes, H Leighton; Beutler, Bruce; Hoebe, Kasper 2010. Loss of T cell and B cell quiescence precedes the onset of microbial flora-dependent wasting disease and intestinal inflammation in Gimap5-deficient mice. Journal of immunology (Baltimore, Md. : 1950), 184 7, 3743-54

Chae, Hee-Don; Siefring, Jamie E; Hildeman, David A; Gu, Yi; Williams, David A 2010. RhoH regulates subcellular localization of ZAP-70 and Lck in T cell receptor signaling. PloS one, 5 11, e13970

Guo, Fukun; Hildeman, David; Tripathi, Pulak; Velu, Chinavenmeni S; Grimes, H Leighton; Zheng, Yi 2010. Coordination of IL-7 receptor and T-cell receptor signaling by cell-division cycle 42 in T-cell homeostasis. Proceedings of the National Academy of Sciences of the United States of America, 107 43, 18505-10

Kasten, Kevin R; Prakash, Priya S; Unsinger, Jacqueline; Goetzman, Holly S; England, Lisa G; Cave, Cindy M; Seitz, Aaron P; Mazuski, Cristina N; Zhou, Tony T; Morre, Michel; Hotchkiss, Richard S; Hildeman, David A; Caldwell, Charles C 2010. Interleukin-7 (IL-7) treatment accelerates neutrophil recruitment through gamma delta T-cell IL-17 production in a murine model of sepsis. Infection and immunity, 78 11, 4714-22

Kasten, Kevin R; Tschöp, Johannes; Adediran, Samuel G; Hildeman, David A; Caldwell, Charles C 2010. T cells are potent early mediators of the host response to sepsis. Shock (Augusta, Ga.), 34 4, 327-36

Kasten, Kevin R; Tschöp, Johannes; Goetzman, Holly S; England, Lisa G; Dattilo, Jonathan R; Cave, Cindy M; Seitz, Aaron P; Hildeman, David A; Caldwell, Charles C 2010. T-cell activation differentially mediates the host response to sepsis. Shock (Augusta, Ga.), 34 4, 377-83

Kurtulus, Sema; Tripathi, Pulak; Opferman, Joseph T; Hildeman, David A 2010. Contracting the 'mus cells'--does down-sizing suit us for diving into the memory pool? Immunological reviews, 236 , 54-67

Lin, Adora A; Wojciechowski, Sara E; Hildeman, David A 2010. Androgens suppress antigen-specific T cell responses and IFN-? production during intracranial LCMV infection. Journal of neuroimmunology, 226 1-2, 8-19

Rudra, Jai S; Tripathi, Pulak K; Hildeman, David A; Jung, Jangwook P; Collier, Joel H 2010. Immune responses to coiled coil supramolecular biomaterials. Biomaterials, 31 32, 8475-83

Tripathi, Pulak; Kurtulus, Sema; Wojciechowski, Sara; Sholl, Allyson; Hoebe, Kasper; Morris, Suzanne C; Finkelman, Fred D; Grimes, H Leighton; Hildeman, David A 2010. STAT5 is critical to maintain effector CD8+ T cell responses. Journal of immunology (Baltimore, Md. : 1950), 185 4, 2116-24

Unsinger, Jacqueline; McGlynn, Margaret; Kasten, Kevin R; Hoekzema, Andrew S; Watanabe, Eizo; Muenzer, Jared T; McDonough, Jacquelyn S; Tschoep, Johannes; Ferguson, Thomas A; McDunn, Jonathan E; Morre, Michel; Hildeman, David A; Caldwell, Charles C; Hotchkiss, Richard S 2010. IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis. Journal of immunology (Baltimore, Md. : 1950), 184 7, 3768-79

Lin, Adora A; Tripathi, Pulak K; Sholl, Allyson; Jordan, Michael B; Hildeman, David A 2009. Gamma interferon signaling in macrophage lineage cells regulates central nervous system inflammation and chemokine production. Journal of virology, 83 17, 8604-15

Madan, Rajat; Demircik, Filiz; Surianarayanan, Sangeetha; Allen, Jessica L; Divanovic, Senad; Trompette, Aurelien; Yogev, Nir; Gu, Yuanyuan; Khodoun, Marat; Hildeman, David; Boespflug, Nicholas; Fogolin, Mariela B; Gröbe, Lothar; Greweling, Marina; Finkelman, Fred D; Cardin, Rhonda; Mohrs, Markus; Müller, Werner; Waisman, Ari; Roers, Axel; Karp, Christopher L 2009. Nonredundant roles for B cell-derived IL-10 in immune counter-regulation. Journal of immunology (Baltimore, Md. : 1950), 183 4, 2312-20

Morris, Suzanne C; Heidorn, Stephanie M; Herbert, De'Broski R; Perkins, Charles; Hildeman, David A; Khodoun, Marat V; Finkelman, Fred D 2009. Endogenously produced IL-4 nonredundantly stimulates CD8+ T cell proliferation. Journal of immunology (Baltimore, Md. : 1950), 182 3, 1429-38

Guo, Fukun; Cancelas, Jose A; Hildeman, David; Williams, David A; Zheng, Yi 2008. Rac GTPase isoforms Rac1 and Rac2 play a redundant and crucial role in T-cell development. Blood, 112 5, 1767-75

Hildeman, David; Janssen, Edith 2008. IFN-gamma and self-absorbed CD4+ T cells: a regulatory double negative. Nature immunology, 9 11, 1210-2

Lages, Celine S; Suffia, Isabelle; Velilla, Paula A; Huang, Bin; Warshaw, Gregg; Hildeman, David A; Belkaid, Yasmin; Chougnet, Claire 2008. Functional regulatory T cells accumulate in aged hosts and promote chronic infectious disease reactivation. Journal of immunology (Baltimore, Md. : 1950), 181 3, 1835-48

Machado, Fabiana S; Esper, Lísia; Dias, Alexandra; Madan, Rajat; Gu, YuanYuan; Hildeman, David; Serhan, Charles N; Karp, Christopher L; Aliberti, Júlio 2008. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. The Journal of experimental medicine, 205 5, 1077-86

Reckling, Stacie; Divanovic, Senad; Karp, Christopher L; Wojciechowski, Sara; Belkaid, Yasmine; Hildeman, David 2008. Proapoptotic Bcl-2 family member Bim promotes persistent infection and limits protective immunity. Infection and immunity, 76 3, 1179-85

Zarebski, Adrian; Velu, Chinavenmeni S; Baktula, Avinash M; Bourdeau, Tristan; Horman, Shane R; Basu, Sudeep; Bertolone, Salvatore J; Horwitz, Marshal; Hildeman, David A; Trent, John O; Grimes, H Leighton 2008. Mutations in growth factor independent-1 associated with human neutropenia block murine granulopoiesis through colony stimulating factor-1. Immunity, 28 3, 370-80

Chougnet, Claire; Hildeman, David A 2007. It's hard to get downstream without a raft: a commentary on "reactive oxygen species promote raft formation in T lymphocytes". Free radical biology & medicine, 42 7, 933-5

DeKoter, Rodney P; Schweitzer, Brock L; Kamath, Meghana B; Jones, Darrel; Tagoh, Hiromi; Bonifer, Constanze; Hildeman, David A; Huang, Kelly J 2007. Regulation of the interleukin-7 receptor alpha promoter by the Ets transcription factors PU.1 and GA-binding protein in developing B cells. The Journal of biological chemistry, 282 19, 14194-204

Hildeman, David; Jorgensen, Trine; Kappler, John; Marrack, Philippa 2007. Apoptosis and the homeostatic control of immune responses. Current opinion in immunology, 19 5, 516-21

Tripathi, Pulak; Mitchell, Thomas C; Finkelman, Fred; Hildeman, David A 2007. Cutting Edge: Limiting amounts of IL-7 do not control contraction of CD4+ T cell responses. Journal of immunology (Baltimore, Md. : 1950), 178 7, 4027-31

Wojciechowski, Sara; Tripathi, Pulak; Bourdeau, Tristan; Acero, Luis; Grimes, H Leighton; Katz, Jonathan D; Finkelman, Fred D; Hildeman, David A 2007. Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. The Journal of experimental medicine, 204 7, 1665-75

Grayson, Jason M; Weant, Ashley E; Holbrook, Beth C; Hildeman, David 2006. Role of Bim in regulating CD8+ T-cell responses during chronic viral infection. Journal of virology, 80 17, 8627-38

Gu, Yi; Chae, Hee-Don; Siefring, Jamie E; Jasti, Aparna C; Hildeman, David A; Williams, David A 2006. RhoH GTPase recruits and activates Zap70 required for T cell receptor signaling and thymocyte development. Nature immunology, 7 11, 1182-90

Tripathi, Pulak; Madan, Rajat; Chougnet, Claire; Divanovic, Senad; Ma, Xiaojing; Wahl, Larry M; Gajewski, Thomas; Karp, Christopher L; Hildeman, David A 2006. An adenoviral vector for probing promoter activity in primary immune cells. Journal of immunological methods, 311 1-2, 19-30

Wojciechowski, Sara; Jordan, Michael B; Zhu, Yanan; White, Janice; Zajac, Allan J; Hildeman, David A 2006. Bim mediates apoptosis of CD127(lo) effector T cells and limits T cell memory. European journal of immunology, 36 7, 1694-706

Zhu, Yanan; Liu, Xinqi; Hildeman, David; Peyerl, Fred W; White, Janice; Kushnir, Elenora; Kappler, John; Marrack, Philippa 2006. Bax does not have to adopt its final form to drive T cell death. The Journal of experimental medicine, 203 5, 1147-52

Fuller, Michael J; Hildeman, David A; Sabbaj, Steffanie; Gaddis, Dalia E; Tebo, Anne E; Shang, Liang; Goepfert, Paul A; Zajac, Allan J 2005. Cutting edge: emergence of CD127high functionally competent memory T cells is compromised by high viral loads and inadequate T cell help. Journal of immunology (Baltimore, Md. : 1950), 174 10, 5926-30

Hawlisch, Heiko; Belkaid, Yasmine; Baelder, Ralf; Hildeman, David; Gerard, Craig; Köhl, Jörg 2005. C5a negatively regulates toll-like receptor 4-induced immune responses. Immunity, 22 4, 415-26

Gardai, Shyra J; Hildeman, David A; Frankel, Steve K; Whitlock, Ben B; Frasch, S Courtney; Borregaard, Niels; Marrack, Philippa; Bratton, Donna L; Henson, Peter M 2004. Phosphorylation of Bax Ser184 by Akt regulates its activity and apoptosis in neutrophils. The Journal of biological chemistry, 279 20, 21085-95

Hildeman, David A 2004. Regulation of T-cell apoptosis by reactive oxygen species. Free radical biology & medicine, 36 12, 1496-504

Ivanovska, Iva; Galonek, Heidi L; Hildeman, David A; Hardwick, J Marie 2004. Regulation of cell death in the lymphoid system by Bcl-2 family proteins. Acta haematologica, 111 1-2, 42-55

Jordan, Michael B; Hildeman, David; Kappler, John; Marrack, Philippa 2004. An animal model of hemophagocytic lymphohistiocytosis (HLH): CD8+ T cells and interferon gamma are essential for the disorder. Blood, 104 3, 735-43

Zhang, Rui; Fichtenbaum, Carl J; Hildeman, David A; Lifson, Jeffrey D; Chougnet, Claire 2004. CD40 ligand dysregulation in HIV infection: HIV glycoprotein 120 inhibits signaling cascades upstream of CD40 ligand transcription. Journal of immunology (Baltimore, Md. : 1950), 172 4, 2678-86

Zhu, Yanan; Swanson, Bradley J; Wang, Michael; Hildeman, David A; Schaefer, Brian C; Liu, Xinqi; Suzuki, Hiroyuki; Mihara, Katsuyoshi; Kappler, John; Marrack, Philippa 2004. Constitutive association of the proapoptotic protein Bim with Bcl-2-related proteins on mitochondria in T cells. Proceedings of the National Academy of Sciences of the United States of America, 101 20, 7681-6

Hildeman, David A; Mitchell, Thomas; Aronow, Bruce; Wojciechowski, Sara; Kappler, John; Marrack, Philippa 2003. Control of Bcl-2 expression by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America, 100 25, 15035-40

Hildeman, David A; Mitchell, Thomas; Kappler, John; Marrack, Philippa 2003. T cell apoptosis and reactive oxygen species. The Journal of clinical investigation, 111 5, 575-81

Hildeman, David A; Zhu, Yanan; Mitchell, Thomas C; Bouillet, Philippe; Strasser, Andreas; Kappler, John; Marrack, Philippa 2002. Activated T cell death in vivo mediated by proapoptotic bcl-2 family member bim. Immunity, 16 6, 759-67

Hildeman, David A; Zhu, Yanan; Mitchell, Thomas C; Kappler, John; Marrack, Philippa 2002. Molecular mechanisms of activated T cell death in vivo. Current opinion in immunology, 14 3, 354-9

Mitchell, Thomas C; Teague, T Kent; Hildeman, David A; Bender, Jeremy; Rees, William A; Kedl, Ross M; Swanson, Brad; Kappler, John W; Marrack, Philippa 2002. Stronger correlation of bcl-3 than bcl-2, bcl-xL, costimulation, or antioxidants with adjuvant-induced T cell survival. Annals of the New York Academy of Sciences, 975 , 114-31