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Heart, Lung and Vascular Institute

Photo of  Bruce Trapnell, MD

Bruce Trapnell, MD

Education/Credentials
  • Bachelor's Degree: University of Maryland
  • Master's Degree: George Washington University and National Heart Lung and Blood Institute, National Institutes of Health
  • Medical Degree: University of Maryland School of Medicine
  • Internship: The Ohio State Unviersity Hospitals
  • Residency : The Ohio State Unviersity Hospitals
  • Visiting Residency: The Brompton Chest Hospital
  • Fellowship: Warren Grant Magnuson Clinical Center, NHLBI, NIH
Contact Information
  • Internal Medicine
  • Medical Sciences Building Room 6065
  • 231 Albert Sabin Way, ML 0564
  • Cincinnati, Ohio 45267
  • Office 513-558-4831
  • Fax 513-558-4858
  • Email bruce.trapnell@cchmc.org
  • UC Institute Member Seal

Peer Reviewed Publications

Gupta, Nishant; Lee, Hye-Seung; Young, Lisa R; Strange, Charlie; Moss, Joel; Singer, Lianne G; Nakata, Koh; Barker, Alan F; Chapman, Jeffrey T; Brantly, Mark L; Stocks, James M; Brown, Kevin K; Lynch, Joseph P; Goldberg, Hilary J; Downey, Gregory P; Taveira-DaSilva, Angelo M; Krischer, Jeffrey P; Setchell, Kenneth; Trapnell, Bruce C; Inoue, Yoshikazu; McCormack, Francis X 2019. Analysis of the MILES cohort reveals determinants of disease progression and treatment response in lymphangioleiomyomatosis. The European respiratory journal, 53 4,

McCarthy, Cormac; Bartholmai, Brian J; Woods, Jason C; McCormack, Francis X; Trapnell, Bruce C 2019. Automated Parenchymal Pattern Analysis of Treatment Responses in Pulmonary Alveolar Proteinosis. American journal of respiratory and critical care medicine, ,

McCarthy, Cormac; Carey, Brenna; Trapnell, Bruce C 2019. Blood Testing for Differential Diagnosis of Pulmonary Alveolar Proteinosis Syndrome. Chest, 155 2, 450-452

Trapnell, Bruce C; Nakata, Koh; Bonella, Francesco; Campo, Ilaria; Griese, Matthias; Hamilton, John; Wang, Tisha; Morgan, Cliff; Cottin, Vincent; McCarthy, Cormac 2019. Pulmonary alveolar proteinosis. Nature reviews. Disease primers, 5 1, 16

Aoki, Ami; Sakagami, Takuro; Yoshizawa, Kazutaka; Shima, Kenjiro; Toyama, Mio; Tanabe, Yoshinari; Moro, Hiroshi; Aoki, Nobumasa; Watanabe, Satoshi; Koya, Toshiyuki; Hasegawa, Takashi; Morimoto, Kozo; Kurashima, Atsuyuki; Hoshino, Yoshihiko; Trapnell, Bruce C; Kikuchi, Toshiaki 2018. Clinical Significance of Interferon-? Neutralizing Autoantibodies Against Disseminated Nontuberculous Mycobacterial Disease. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America, 66 8, 1239-1245

Hiruma, Takahiro; Tsuyuzaki, Hitoshi; Uchida, Kanji; Trapnell, Bruce C; Yamamura, Yoshiro; Kusakabe, Yoshiomi; Totsu, Tokie; Suzuki, Takuji; Morita, Shigeki; Doi, Kent; Noiri, Eisei; Nakamura, Kensuke; Nakajima, Susumu; Yahagi, Naoki; Morimura, Naoto; Chang, Kyungho; Yamada, Yoshitsugu 2018. IFN-? Improves Sepsis-related Alveolar Macrophage Dysfunction and Postseptic Acute Respiratory Distress Syndrome-related Mortality. American journal of respiratory cell and molecular biology, 59 1, 45-55

McCarthy, Cormac; Avetisyan, Ruzan; Carey, Brenna C; Chalk, Claudia; Trapnell, Bruce C 2018. Prevalence and healthcare burden of pulmonary alveolar proteinosis. Orphanet journal of rare diseases, 13 1, 129

McCarthy, Cormac; Brewington, John J; Harkness, Beth; Clancy, John P; Trapnell, Bruce C 2018. Personalised CFTR pharmacotherapeutic response testing and therapy of cystic fibrosis. The European respiratory journal, 51 6,

McCarthy, Cormac; Carey, Brenna; Trapnell, Bruce C 2018. Blood testing in the diagnosis of pulmonary alveolar proteinosis. The Lancet. Respiratory medicine, 6 11, e54

McCarthy, Cormac; Lee, Elinor; Bridges, James P; Sallese, Anthony; Suzuki, Takuji; Woods, Jason C; Bartholmai, Brian J; Wang, Tisha; Chalk, Claudia; Carey, Brenna C; Arumugam, Paritha; Shima, Kenjiro; Tarling, Elizabeth J; Trapnell, Bruce C 2018. Statin as a novel pharmacotherapy of pulmonary alveolar proteinosis. Nature communications, 9 1, 3127

Wright, Sandra S; Trauernicht, Anna; Bonkowski, Erin; McCall, Courtney A; Maier, Elizabeth A; Bezold, Ramona; Lake, Kathleen; Chalk, Claudia; Trapnell, Bruce C; Kim, Mi-Ok; Kugathasan, Subra; Denson, Lee A 2018. Familial Association of Granulocyte-Macrophage Colony-Stimulating Factor Autoantibodies in Inflammatory Bowel Disease. Journal of pediatric gastroenterology and nutrition, 66 5, 767-772

Hetzel, Miriam; Suzuki, Takuji; Hashtchin, Anna Rafiei; Arumugam, Paritha; Carey, Brenna; Schwabbauer, Marc; Kuhn, Alexandra; Meyer, Johann; Schambach, Axel; Van Der Loo, Johannes; Moritz, Thomas; Trapnell, Bruce C; Lachmann, Nico 2017. Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency. Human gene therapy methods, 28 6, 318-329

Kristof, Arnold S; Petrof, Basil J; Hamid, Qutayba; Kolb, Martin; Landry, Jennifer S; MacKenzie, Alex; McCormack, Francis X; Murawski, Inga J; Moss, Joel; Rauch, Frank; Rosas, Ivan O; Shapiro, Adam J; Smith, Benjamin M; Thomas, David Y; Trapnell, Bruce C; Young, Lisa R; Zariwala, Maimoona A 2017. An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases. Annals of the American Thoracic Society, 14 8, 1239-1247

Kugathasan, Subra; Denson, Lee A; Walters, Thomas D; Kim, Mi-Ok; Marigorta, Urko M; Schirmer, Melanie; Mondal, Kajari; Liu, Chunyan; Griffiths, Anne; Noe, Joshua D; Crandall, Wallace V; Snapper, Scott; Rabizadeh, Shervin; Rosh, Joel R; Shapiro, Jason M; Guthery, Stephen; Mack, David R; Kellermayer, Richard; Kappelman, Michael D; Steiner, Steven; Moulton, Dedrick E; Keljo, David; Cohen, Stanley; Oliva-Hemker, Maria; Heyman, Melvin B; Otley, Anthony R; Baker, Susan S; Evans, Jonathan S; Kirschner, Barbara S; Patel, Ashish S; Ziring, David; Trapnell, Bruce C; Sylvester, Francisco A; Stephens, Michael C; Baldassano, Robert N; Markowitz, James F; Cho, Judy; Xavier, Ramnik J; Huttenhower, Curtis; Aronow, Bruce J; Gibson, Greg; Hyams, Jeffrey S; Dubinsky, Marla C 2017. Prediction of complicated disease course for children newly diagnosed with Crohn's disease: a multicentre inception cohort study. Lancet (London, England), 389 10080, 1710-1718

McCarthy, Cormac; Lara Gallego, Beatriz; Trapnell, Bruce C; McCormack, Francis X 2017. Epidemiology of Rare Lung Diseases: The Challenges and Opportunities to Improve Research and Knowledge. Advances in experimental medicine and biology, 1031 , 419-442

Mueller, Christian; Gernoux, Gwladys; Gruntman, Alisha M; Borel, Florie; Reeves, Emer P; Calcedo, Roberto; Rouhani, Farshid N; Yachnis, Anthony; Humphries, Margaret; Campbell-Thompson, Martha; Messina, Louis; Chulay, Jeffrey D; Trapnell, Bruce; Wilson, James M; McElvaney, Noel G; Flotte, Terence R 2017. 5 Year Expression and Neutrophil Defect Repair after Gene Therapy in Alpha-1 Antitrypsin Deficiency. Molecular therapy : the journal of the American Society of Gene Therapy, ,

Sallese, Anthony; Suzuki, Takuji; McCarthy, Cormac; Bridges, James; Filuta, Alyssa; Arumugam, Paritha; Shima, Kenjiro; Ma, Yan; Wessendarp, Matthew; Black, Diane; Chalk, Claudia; Carey, Brenna; Trapnell, Bruce C 2017. Targeting cholesterol homeostasis in lung diseases. Scientific reports, 7 1, 10211

Trapnell, Bruce C; Bridges, James 2017. Does Granulocyte-Macrophage Colony-Stimulating Factor Coordinate a Hepatopulmonary Axis of Lipid Metabolism? American journal of respiratory cell and molecular biology, 57 4, 383-385

Acciani, T H; Suzuki, T; Trapnell, B C; Le Cras, T D 2016. Epidermal growth factor receptor signalling regulates granulocyte-macrophage colony-stimulating factor production by airway epithelial cells and established allergic airway disease. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology, 46 2, 317-28

Campo, Ilaria; Luisetti, Maurizio; Griese, Matthias; Trapnell, Bruce C; Bonella, Francesco; Grutters, Jan C; Nakata, Koh; Van Moorsel, Coline H M; Costabel, Ulrich; Cottin, Vincent; Ichiwata, Toshio; Inoue, Yoshikazu; Braschi, Antonio; Bonizzoni, Giacomo; Iotti, Giorgio A; Tinelli, Carmine; Rodi, Giuseppe 2016. A Global Survey on Whole Lung Lavage in Pulmonary Alveolar Proteinosis. Chest, 150 1, 251-3

Campo, Ilaria; Luisetti, Maurizio; Griese, Matthias; Trapnell, Bruce C; Bonella, Francesco; Grutters, Jan; Nakata, Koh; Van Moorsel, Coline H M; Costabel, Ulrich; Cottin, Vincent; Ichiwata, Toshio; Inoue, Yoshikazu; Braschi, Antonio; Bonizzoni, Giacomo; Iotti, Giorgio A; Tinelli, Carmine; Rodi, Giuseppe 2016. Whole lung lavage therapy for pulmonary alveolar proteinosis: a global survey of current practices and procedures. Orphanet journal of rare diseases, 11 1, 115

Cummings, Kristin J; Virji, M Abbas; Park, Ji Young; Stanton, Marcia L; Edwards, Nicole T; Trapnell, Bruce C; Carey, Brenna; Stefaniak, Aleksandr B; Kreiss, Kathleen 2016. Respirable indium exposures, plasma indium, and respiratory health among indium-tin oxide (ITO) workers. American journal of industrial medicine, 59 7, 522-31

Mucci, Adele; Kunkiel, Jessica; Suzuki, Takuji; Brennig, Sebastian; Glage, Silke; Kühnel, Mark P; Ackermann, Mania; Happle, Christine; Kuhn, Alexandra; Schambach, Axel; Trapnell, Bruce C; Hansen, Gesine; Moritz, Thomas; Lachmann, Nico 2016. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem cell reports, 7 2, 292-305

Schnepp, Bruce C; Chulay, Jeffrey D; Ye, Guo-Jie; Flotte, Terence R; Trapnell, Bruce C; Johnson, Philip R 2016. Recombinant Adeno-Associated Virus Vector Genomes Take the Form of Long-Lived, Transcriptionally Competent Episomes in Human Muscle. Human gene therapy, 27 1, 32-42

Suzuki, Takuji; Trapnell, Bruce C 2016. Pulmonary Alveolar Proteinosis Syndrome. Clinics in chest medicine, 37 3, 431-40

Young, Lisa R; Trapnell, Bruce C; Mandl, Kenneth D; Swarr, Daniel T; Wambach, Jennifer A; Blaisdell, Carol J 2016. Accelerating Scientific Advancement for Pediatric Rare Lung Disease Research. Report from a National Institutes of Health-NHLBI Workshop, September 3 and 4, 2015. Annals of the American Thoracic Society, 13 12, 385-393

Fan, Leland L; Dishop, Megan K; Galambos, Csaba; Askin, Frederic B; White, Frances V; Langston, Claire; Liptzin, Deborah R; Kroehl, Miranda E; Deutsch, Gail H; Young, Lisa R; Kurland, Geoffrey; Hagood, James; Dell, Sharon; Trapnell, Bruce C; Deterding, Robin R 2015. Diffuse Lung Disease in Biopsied Children 2 to 18 Years of Age. Application of the chILD Classification Scheme. Annals of the American Thoracic Society, 12 10, 1498-505

Trapnell, Bruce C 2015. A lymphocyte-mediated cause of secondary PAP. Blood, 125 2, 215-6

Cummings, Kristin J; Virji, M Abbas; Trapnell, Bruce C; Carey, Brenna; Healey, Terrance; Kreiss, Kathleen 2014. Early changes in clinical, functional, and laboratory biomarkers in workers at risk of indium lung disease. Annals of the American Thoracic Society, 11 9, 1395-403

Kusakabe, Yoshiomi; Uchida, Kanji; Hiruma, Takahiro; Suzuki, Yoko; Totsu, Tokie; Suzuki, Takuji; Carey, Brenna C; Yamada, Yoshitsugu; Trapnell, Bruce C 2014. A standardized blood test for the routine clinical diagnosis of impaired GM-CSF signaling using flow cytometry. Journal of immunological methods, ,

Suzuki, Takuji; Arumugam, Paritha; Sakagami, Takuro; Lachmann, Nico; Chalk, Claudia; Sallese, Anthony; Abe, Shuichi; Trapnell, Cole; Carey, Brenna; Moritz, Thomas; Malik, Punam; Lutzko, Carolyn; Wood, Robert E; Trapnell, Bruce C 2014. Pulmonary macrophage transplantation therapy. Nature, 514 7523, 450-4

Suzuki, Takuji; Mayhew, Christopher; Sallese, Anthony; Chalk, Claudia; Carey, Brenna C; Malik, Punam; Wood, Robert E; Trapnell, Bruce C 2014. Use of induced pluripotent stem cells to recapitulate pulmonary alveolar proteinosis pathogenesis. American journal of respiratory and critical care medicine, 189 2, 183-93

Trapnell, Bruce C 2014. The dawn of protein-folding therapeutics. American journal of respiratory and critical care medicine, 189 1, 1-3

Uchida, Kanji; Nakata, Koh; Carey, Brenna; Chalk, Claudia; Suzuki, Takuji; Sakagami, Takuro; Koch, Diana E; Stevens, Carrie; Inoue, Yoshikazu; Yamada, Yoshitsugu; Trapnell, Bruce C 2014. Standardized serum GM-CSF autoantibody testing for the routine clinical diagnosis of autoimmune pulmonary alveolar proteinosis. Journal of immunological methods, 402 1-2, 57-70

Campo, Ilaria; Mariani, Francesca; Rodi, Giuseppe; Paracchini, Elena; Tsana, Eric; Piloni, Davide; Nobili, Isabella; Kadija, Zamir; Corsico, Angelo; Cerveri, Isa; Chalk, Claudia; Trapnell, Bruce C; Braschi, Antonio; Tinelli, Carmine; Luisetti, Maurizio 2013. Assessment and management of pulmonary alveolar proteinosis in a reference center. Orphanet journal of rare diseases, 8 , 40

Däbritz, Jan; Bonkowski, Erin; Chalk, Claudia; Trapnell, Bruce C; Langhorst, Jost; Denson, Lee A; Foell, Dirk 2013. Granulocyte macrophage colony-stimulating factor auto-antibodies and disease relapse in inflammatory bowel disease. The American journal of gastroenterology, 108 12, 1901-10

Dykes, Dana M H; Towbin, Alexander J; Bonkowski, Erin; Chalk, Claudia; Bezold, Ramona; Lake, Kathleen; Kim, Mi-Ok; Heubi, James E; Trapnell, Bruce C; Podberesky, Daniel J; Denson, Lee A 2013. Increased prevalence of luminal narrowing and stricturing identified by enterography in pediatric Crohn's disease patients with elevated granulocyte-macrophage colony stimulating factor autoantibodies. Inflammatory bowel diseases, 19 10, 2146-54

Gathungu, Grace; Kim, Mi-Ok; Ferguson, John P; Sharma, Yashoda; Zhang, Wei; Ng, Sok Meng E; Bonkowski, Erin; Ning, Kaida; Simms, Lisa A; Croft, Anthony R; Stempak, Joanne M; Walker, Nicole; Huang, Ning; Xiao, Yang; Silverberg, Mark S; Trapnell, Bruce; Cho, Judy H; Radford-Smith, Graham L; Denson, Lee A 2013. Granulocyte-macrophage colony-stimulating factor autoantibodies: a marker of aggressive Crohn's disease. Inflammatory bowel diseases, 19 8, 1671-80

Jurickova, I; Collins, M H; Chalk, C; Seese, A; Bezold, R; Lake, K; von Allmen, D; Frischer, J S; Falcone, R A; Trapnell, B C; Denson, L A 2013. Paediatric Crohn disease patients with stricturing behaviour exhibit ileal granulocyte-macrophage colony-stimulating factor (GM-CSF) autoantibody production and reduced neutrophil bacterial killing and GM-CSF bioactivity. Clinical and experimental immunology, 172 3, 455-65

Matthay, Michael A; Anversa, Piero; Bhattacharya, Jahar; Burnett, Bruce K; Chapman, Harold A; Hare, Joshua M; Hei, Derek J; Hoffman, Andrew M; Kourembanas, Stella; McKenna, David H; Ortiz, Luis A; Ott, Harald C; Tente, William; Thébaud, Bernard; Trapnell, Bruce C; Weiss, Daniel J; Yuan, Jason X-J; Blaisdell, Carol J 2013. Cell therapy for lung diseases. Report from an NIH-NHLBI workshop, November 13-14, 2012. American journal of respiratory and critical care medicine, 188 3, 370-5

Mueller, Christian; Chulay, Jeffrey D; Trapnell, Bruce C; Humphries, Margaret; Carey, Brenna; Sandhaus, Robert A; McElvaney, Noel G; Messina, Louis; Tang, Qiushi; Rouhani, Farshid N; Campbell-Thompson, Martha; Fu, Ann Dongtao; Yachnis, Anthony; Knop, David R; Ye, Guo-Jie; Brantly, Mark; Calcedo, Roberto; Somanathan, Suryanarayan; Richman, Lee P; Vonderheide, Robert H; Hulme, Maigan A; Brusko, Todd M; Wilson, James M; Flotte, Terence R 2013. Human Treg responses allow sustained recombinant adeno-associated virus-mediated transgene expression. The Journal of clinical investigation, 123 12, 5310-8

Trapnell, Bruce C; Luisetti, Maurizio 2013. The parallel lives of alpha1-antitrypsin deficiency and pulmonary alveolar proteinosis. Orphanet journal of rare diseases, 8 , 153

Young, Lisa; Lee, Hye-Seung; Inoue, Yoshikazu; Moss, Joel; Singer, Lianne G; Strange, Charlie; Nakata, Koh; Barker, Alan F; Chapman, Jeffrey T; Brantly, Mark L; Stocks, James M; Brown, Kevin K; Lynch, Joseph P; Goldberg, Hilary J; Downey, Gregory P; Swigris, Jeffrey J; Taveira-DaSilva, Angelo M; Krischer, Jeffrey P; Trapnell, Bruce C; McCormack, Francis X 2013. Serum VEGF-D a concentration as a biomarker of lymphangioleiomyomatosis severity and treatment response: a prospective analysis of the Multicenter International Lymphangioleiomyomatosis Efficacy of Sirolimus (MILES) trial. The Lancet. Respiratory medicine, 1 6, 445-52

Cummings, Kristin J; Nakano, Makiko; Omae, Kazuyuki; Takeuchi, Koichiro; Chonan, Tatsuya; Xiao, Yong-long; Harley, Russell A; Roggli, Victor L; Hebisawa, Akira; Tallaksen, Robert J; Trapnell, Bruce C; Day, Gregory A; Saito, Rena; Stanton, Marcia L; Suarthana, Eva; Kreiss, Kathleen 2012. Indium lung disease. Chest, 141 6, 1512-21

Luisetti, Maurizio; Balfour-Lynn, Ian M; Johnson, Simon R; Miravitlles, Marc; Strange, Charlie; Trapnell, Bruce C; van Bronswijk, Hans; Vogelmeier, Claus 2012. Perspectives for improving the evaluation and access of therapies for rare lung diseases in Europe. Respiratory medicine, 106 6, 759-68

Trapnell, Bruce C 2012. Induced sputum biomarkers for monitoring cystic fibrosis lung disease. American journal of respiratory and critical care medicine, 186 9, 812-4

Trapnell, Bruce C 2012. Inhaled dry powder mannitol: a solution for cystic fibrosis. American journal of respiratory and critical care medicine, 185 6, 596-8

Trapnell, Bruce C; McColley, Susanna A; Kissner, Dana G; Rolfe, Mark W; Rosen, Jonathan M; McKevitt, Matthew; Moorehead, Lisa; Montgomery, A Bruce; Geller, David E 2012. Fosfomycin/tobramycin for inhalation in patients with cystic fibrosis with pseudomonas airway infection. American journal of respiratory and critical care medicine, 185 2, 171-8

D'Mello, Sharon; Trauernicht, Anna; Ryan, Anne; Bonkowski, Erin; Willson, Tara; Trapnell, Bruce C; Frank, Stuart J; Kugasathan, Subra; Denson, Lee A 2011. Innate dysfunction promotes linear growth failure in pediatric Crohn's disease and growth hormone resistance in murine ileitis. Inflammatory bowel diseases, ,

Duvoix, Annelyse; Miranda, Elena; Perez, Juan; Sorensen, Grith L; Holmskov, Uffe; Trapnell, Bruce C; Madsen, Jens; Clark, Howard W; Edwards, Lisa D; Miller, Bruce E; Tal-Singer, Ruth M; Lomas, David A 2011. Evaluation of full-length, cleaved and nitrosylated serum surfactant protein D as biomarkers for COPD. COPD, 8 2, 79-95

Flotte, Terence R; Trapnell, Bruce C; Humphries, Margaret; Carey, Brenna; Calcedo, Roberto; Rouhani, Farshid; Campbell-Thompson, Martha; Yachnis, Anthony T; Sandhaus, Robert A; McElvaney, Noel G; Mueller, Christian; Messina, Louis M; Wilson, James M; Brantly, Mark; Knop, David R; Ye, Guo-Jie; Chulay, Jeffrey David 2011. Phase 2 Clinical Trial of a Recombinant Adeno-associated Virus Vector Expressing Alpha 1 Antitrypsin: Interim Results. Human gene therapy, ,

Ishii, H; Tazawa, R; Kaneko, C; Saraya, T; Inoue, Y; Hamano, E; Kogure, Y; Tomii, K; Terada, M; Takada, T; Hojo, M; Nishida, A; Ichiwata, T; Trapnell, B C; Goto, H; Nakata, K 2011. Clinical features of secondary pulmonary alveolar proteinosis: pre-mortem cases in Japan. The European respiratory journal, 37 2, 465-8

Luisetti, Maurizio; Bruno, Pierdonato; Kadija, Zamir; Suzuki, Takuji; Raffa, Salvatore; Torrisi, Maria Rosaria; Campo, Ilaria; Mariani, Francesca; Pozzi, Ernesto; Trapnell, Bruce C; Mariotta, Salvatore 2011. Relationship Among Diffuse Pulmonary Fibrosis, Alveolar Proteinosis And Anti-GM-CSF Autoantibodies. Respiratory care, ,

Luisetti, Maurizio; Kroneberg, Philipp; Suzuki, Takuji; Kadija, Zamir; Muellinger, Bernhard; Campo, Ilaria; Gleske, Juliane; Rodi, Giuseppe; Zimlich, William C; Mariani, Francesca; Ferrari, Fabio; Frey, Manuel; Trapnell, Bruce C 2011. Physical properties, lung deposition modeling, and bioactivity of recombinant GM-CSF aerosolised with a highly efficient nebulizer. Pulmonary pharmacology & therapeutics, 24 1, 123-7

McCormack, Francis X; Inoue, Yoshikazu; Moss, Joel; Singer, Lianne G; Strange, Charlie; Nakata, Koh; Barker, Alan F; Chapman, Jeffrey T; Brantly, Mark L; Stocks, James M; Brown, Kevin K; Lynch, Joseph P; Goldberg, Hilary J; Young, Lisa R; Kinder, Brent W; Downey, Gregory P; Sullivan, Eugene J; Colby, Thomas V; McKay, Roy T; Cohen, Marsha M; Korbee, Leslie; Taveira-DaSilva, Angelo M; Lee, Hye-Seung; Krischer, Jeffrey P; Trapnell, Bruce C 2011. Efficacy and safety of sirolimus in lymphangioleiomyomatosis. The New England journal of medicine, 364 17, 1595-606

Nylund, Cade M; D'Mello, Sharon; Kim, Mi-Ok; Bonkowski, Erin; Däbritz, Jan; Foell, Dirk; Meddings, Jon; Trapnell, Bruce C; Denson, Lee A 2011. Granulocyte macrophage-colony-stimulating factor autoantibodies and increased intestinal permeability in Crohn disease. Journal of pediatric gastroenterology and nutrition, 52 5, 542-8

Samson, Charles M; Jurickova, Ingrid; Molden, Erin; Schreiner, William; Colliver, Joshua; Bonkowski, Erin; Han, Xiaonan; Trapnell, Bruce C; Denson, Lee A 2011. Granulocyte-macrophage colony stimulating factor blockade promotes ccr9(+) lymphocyte expansion in Nod2 deficient mice. Inflammatory bowel diseases, ,

Suzuki, T; Maranda, B; Sakagami, T; Catellier, P; Couture, C-Y; Carey, B C; Chalk, C; Trapnell, B C 2011. Hereditary pulmonary alveolar proteinosis caused by recessive CSF2RB mutations. The European respiratory journal, 37 1, 201-4

Trapnell, Bruce C; Strausbaugh, Steven D; Woo, Marlyn S; Tong, Shin-Yir; Silber, Steven A; Mulberg, Andrew E; Leitz, Gerhard 2011. Efficacy and safety of PANCREAZE® for treatment of exocrine pancreatic insufficiency due to cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, ,

Wu, Huixing; Suzuki, Takuji; Carey, Brenna; Trapnell, Bruce C; McCormack, Francis X 2011. Keratinocyte growth factor augments pulmonary innate immunity through epithelium-driven, GM-CSF-dependent paracrine activation of alveolar macrophages. The Journal of biological chemistry, 286 17, 14932-40

Carey, Brenna; Trapnell, Bruce C 2010. The molecular basis of pulmonary alveolar proteinosis. Clinical immunology (Orlando, Fla.), 135 2, 223-35

Han, Xiaonan; Gilbert, Shila; Groschwitz, Katherine; Hogan, Simon; Jurickova, Ingrid; Trapnell, Bruce; Samson, Charles; Gully, Jonathan 2010. Loss of GM-CSF signalling in non-haematopoietic cells increases NSAID ileal injury. Gut, 59 8, 1066-78

Luisetti, Maurizio; Kadija, Zamir; Mariani, Francesca; Rodi, Giuseppe; Campo, Ilaria; Trapnell, Bruce C 2010. Therapy options in pulmonary alveolar proteinosis. Therapeutic advances in respiratory disease, 4 4, 239-48

Sakagami, Takuro; Beck, David; Uchida, Kanji; Suzuki, Takuji; Carey, Brenna C; Nakata, Koh; Keller, Gary; Wood, Robert E; Wert, Susan E; Ikegami, Machiko; Whitsett, Jeffrey A; Luisetti, Maurizio; Davies, Stella; Krischer, Jeffrey P; Brody, Alan; Ryckman, Fred; Trapnell, Bruce C 2010. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. American journal of respiratory and critical care medicine, 182 1, 49-61

Suzuki, Takuji; Sakagami, Takuro; Young, Lisa R; Carey, Brenna C; Wood, Robert E; Luisetti, Maurizio; Wert, Susan E; Rubin, Bruce K; Kevill, Katharine; Chalk, Claudia; Whitsett, Jeffrey A; Stevens, Carrie; Nogee, Lawrence M; Campo, Ilaria; Trapnell, Bruce C 2010. Hereditary pulmonary alveolar proteinosis: pathogenesis, presentation, diagnosis, and therapy. American journal of respiratory and critical care medicine, 182 10, 1292-304

Tazawa, Ryushi; Trapnell, Bruce C; Inoue, Yoshikazu; Arai, Toru; Takada, Toshinori; Nasuhara, Yasuyuki; Hizawa, Nobuyuki; Kasahara, Yasunori; Tatsumi, Koichiro; Hojo, Masayuki; Ishii, Haruyuki; Yokoba, Masanori; Tanaka, Naohiko; Yamaguchi, Etsuro; Eda, Ryosuke; Tsuchihashi, Yoshiko; Morimoto, Konosuke; Akira, Masanori; Terada, Masaki; Otsuka, Junji; Ebina, Masahito; Kaneko, Chinatsu; Nukiwa, Toshihiro; Krischer, Jeffrey P; Akazawa, Kohei; Nakata, Koh 2010. Inhaled granulocyte/macrophage-colony stimulating factor as therapy for pulmonary alveolar proteinosis. American journal of respiratory and critical care medicine, 181 12, 1345-54

Uchida, Kanji; Carey, Brenna; Suzuki, Takuji; Nakata, Koh; Trapnell, Bruce 2010. Response: Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy persons. Blood, 115 2, 431-3

Watanabe, Masato; Uchida, Kanji; Nakagaki, Kazuhide; Trapnell, Bruce C; Nakata, Koh 2010. High avidity cytokine autoantibodies in health and disease: pathogenesis and mechanisms. Cytokine & growth factor reviews, 21 4, 263-73

Young, Lisa R; Vandyke, Rhonda; Gulleman, Peter M; Inoue, Yoshikazu; Brown, Kevin K; Schmidt, Laura S; Linehan, W Marston; Hajjar, Fuad; Kinder, Brent W; Trapnell, Bruce C; Bissler, John J; Franz, David N; McCormack, Francis X 2010. Serum vascular endothelial growth factor-D prospectively distinguishes lymphangioleiomyomatosis from other diseases. Chest, 138 3, 674-81

Griggs, Robert C; Batshaw, Mark; Dunkle, Mary; Gopal-Srivastava, Rashmi; Kaye, Edward; Krischer, Jeffrey; Nguyen, Tan; Paulus, Kathleen; Merkel, Peter A 2009. Clinical research for rare disease: opportunities, challenges, and solutions. Molecular genetics and metabolism, 96 1, 20-6

Han, Xiaonan; Uchida, Kanji; Jurickova, Ingrid; Koch, Diana; Willson, Tara; Samson, Charles; Bonkowski, Erin; Trauernicht, Anna; Kim, Mi-Ok; Tomer, Gitit; Dubinsky, Marla; Plevy, Scott; Kugathsan, Subra; Trapnell, Bruce C; Denson, Lee A 2009. Granulocyte-macrophage colony-stimulating factor autoantibodies in murine ileitis and progressive ileal Crohn's disease. Gastroenterology, 136 4, 1261-71, e1-3

Ishii, Haruyuki; Trapnell, Bruce C; Tazawa, Ryushi; Inoue, Yoshikazu; Akira, Masanori; Kogure, Yoshihito; Tomii, Keisuke; Takada, Toshinori; Hojo, Masayuki; Ichiwata, Toshio; Goto, Hajime; Nakata, Koh 2009. Comparative study of high-resolution CT findings between autoimmune and secondary pulmonary alveolar proteinosis. Chest, 136 5, 1348-55

Luisetti, M; Rodi, G; Perotti, C; Campo, I; Mariani, F; Pozzi, E; Trapnell, B C 2009. Plasmapheresis for treatment of pulmonary alveolar proteinosis. The European respiratory journal, 33 5, 1220-2

Robinson, Terry E; Trapnell, Bruce C; Goris, Michael L; Quittell, Lynne M; Cornfield, David N 2009. Quantitative analysis of longitudinal response to aerosolized granulocyte-macrophage colony-stimulating factor in two adolescents with autoimmune pulmonary alveolar proteinosis. Chest, 135 3, 842-8

Sakagami, Takuro; Uchida, Kanji; Suzuki, Takuji; Carey, Brenna C; Wood, Robert E; Wert, Susan E; Whitsett, Jeffrey A; Trapnell, Bruce C; Luisetti, Maurizio 2009. Human GM-CSF autoantibodies and reproduction of pulmonary alveolar proteinosis. The New England journal of medicine, 361 27, 2679-81

Trapnell, Bruce C 2009. A novel biomarker-guided immunomodulatory approach for the therapy of sepsis. American journal of respiratory and critical care medicine, 180 7, 585-6

Trapnell, Bruce C; Carey, Brenna C; Uchida, Kanji; Suzuki, Takuji 2009. Pulmonary alveolar proteinosis, a primary immunodeficiency of impaired GM-CSF stimulation of macrophages. Current opinion in immunology, 21 5, 514-21

Trapnell, Bruce C; Maguiness, Karen; Graff, Gavin R; Boyd, David; Beckmann, Katrin; Caras, Steven 2009. Efficacy and safety of Creon 24,000 in subjects with exocrine pancreatic insufficiency due to cystic fibrosis. Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society, 8 6, 370-7

Uchida, Kanji; Nakata, Koh; Suzuki, Takuji; Luisetti, Maurizio; Watanabe, Masato; Koch, Diana E; Stevens, Carrie A; Beck, David C; Denson, Lee A; Carey, Brenna C; Keicho, Naoto; Krischer, Jeffrey P; Yamada, Yoshitsugu; Trapnell, Bruce C 2009. Granulocyte/macrophage-colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy subjects. Blood, 113 11, 2547-56

Inoue, Yoshikazu; Trapnell, Bruce C; Tazawa, Ryushi; Arai, Toru; Takada, Toshinori; Hizawa, Nobuyuki; Kasahara, Yasunori; Tatsumi, Koichiro; Hojo, Masaaki; Ichiwata, Toshio; Tanaka, Naohiko; Yamaguchi, Etsuro; Eda, Ryosuke; Oishi, Kazunori; Tsuchihashi, Yoshiko; Kaneko, Chinatsu; Nukiwa, Toshihiro; Sakatani, Mitsunori; Krischer, Jeffrey P; Nakata, Koh 2008. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. American journal of respiratory and critical care medicine, 177 7, 752-62

Kleff, Veronika; Sorg, Ursula R; Bury, Carsten; Suzuki, Takuji; Rattmann, Ina; Jerabek-Willemsen, Moran; Poremba, Christopher; Flasshove, Michael; Opalka, Bertram; Trapnell, Bruce; Dirksen, Uta; Moritz, Thomas 2008. Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model. Molecular therapy : the journal of the American Society of Gene Therapy, 16 4, 757-64

Kleff, Veronika; Sorg, Ursula R; Bury, Carsten; Suzuki, Takuji; Rattmann, Ina; Jerabek-Willemsen, Moran; Poremba, Christopher; Flasshove, Michael; Opalka, Bertram; Trapnell, Bruce; Dirksen, Uta; Moritz, Thomas 2008. Gene Therapy of ?c-Deficient Pulmonary Alveolar Proteinosis (?c-PAP): Studies in a Murine in vivo Model. Molecular therapy : the journal of the American Society of Gene Therapy, 16 4, 757-764

Sandhaus, Robert A; Turino, Gerard; Stocks, James; Strange, Charlie; Trapnell, Bruce C; Silverman, Edwin K; Everett, Sarah E; Stoller, James K 2008. alpha1-Antitrypsin augmentation therapy for PI*MZ heterozygotes: a cautionary note. Chest, 134 4, 831-4

Spight, Donn; Trapnell, Bruce; Zhao, Bin; Berclaz, Pierre; Shanley, Thomas P 2008. Granulocyte-macrophage-colony-stimulating factor-dependent peritoneal macrophage responses determine survival in experimentally induced peritonitis and sepsis in mice. Shock (Augusta, Ga.), 30 4, 434-42

Suzuki, Takuji; Sakagami, Takuro; Rubin, Bruce K; Nogee, Lawrence M; Wood, Robert E; Zimmerman, Sarah L; Smolarek, Teresa; Dishop, Megan K; Wert, Susan E; Whitsett, Jeffrey A; Grabowski, Gregory; Carey, Brenna C; Stevens, Carrie; van der Loo, Johannes C M; Trapnell, Bruce C 2008. Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA. The Journal of experimental medicine, 205 12, 2703-10

Uchida, Kanji; Nakata, Koh; Suzuki, Takuji; Luisetti, Maurizio; Watanabe, Masato; Koch, Diana E; Stevens, Carrie A; Beck, Dave C; Denson, Lee A; Carey, Brenna C; Keicho, Naoto; Krischer, Jeffrey P; Yamada, Yoshitsugu; Trapnell, Bruce C 2008. Granulocyte/macrophage colony-stimulating factor autoantibodies and myeloid cell immune functions in healthy individuals. Blood, ,

Berclaz, Pierre-Yves; Carey, Brenna; Fillipi, Marie-Dominique; Wernke-Dollries, Kara; Geraci, Nick; Cush, Stephanie; Richardson, Terry; Kitzmiller, Joe; O'connor, Michael; Hermoyian, Christina; Korfhagen, Thomas; Whitsett, Jeffrey A; Trapnell, Bruce C 2007. GM-CSF regulates a PU.1-dependent transcriptional program determining the pulmonary response to LPS. American journal of respiratory cell and molecular biology, 36 1, 114-21

Carey, Brenna; Staudt, Margaret K; Bonaminio, Dana; van der Loo, Johannes C M; Trapnell, Bruce C 2007. PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection. Journal of immunology (Baltimore, Md. : 1950), 178 4, 2440-7

Deutsch, Gail H; Young, Lisa R; Deterding, Robin R; Fan, Leland L; Dell, Sharon D; Bean, Judy A; Brody, Alan S; Nogee, Lawrence M; Trapnell, Bruce C; Langston, Claire ; Albright, Eric A; Askin, Frederic B; Baker, Peter; Chou, Pauline M; Cool, Carlyne M; Coventry, Susan C; Cutz, Ernest; Davis, Mary M; Dishop, Megan K; Galambos, Csaba; Patterson, Kathleen; Travis, William D; Wert, Susan E; White, Frances V 2007. Diffuse lung disease in young children: application of a novel classification scheme. American journal of respiratory and critical care medicine, 176 11, 1120-8

Perlmutter, David H; Brodsky, Jeffrey L; Balistreri, William F; Trapnell, Bruce C 2007. Molecular pathogenesis of alpha-1-antitrypsin deficiency-associated liver disease: a meeting review. Hepatology (Baltimore, Md.), 45 5, 1313-23

Uchida, Kanji; Beck, David C; Yamamoto, Takashi; Berclaz, Pierre-Yves; Abe, Shuichi; Staudt, Margaret K; Carey, Brenna C; Filippi, Marie-Dominique; Wert, Susan E; Denson, Lee A; Puchalski, Jonathan T; Hauck, Diane M; Trapnell, Bruce C 2007. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. The New England journal of medicine, 356 6, 567-79

Watanabe, Masato; Uchida, Kanji; Nakagaki, Kazuhide; Kanazawa, Hiroko; Trapnell, Bruce C; Hoshino, Yoshihiko; Kagamu, Hiroshi; Yoshizawa, Hirohisa; Keicho, Naoto; Goto, Hajime; Nakata, Koh 2007. Anti-cytokine autoantibodies are ubiquitous in healthy individuals. FEBS letters, 581 10, 2017-21

Gonzalez-Juarrero, Mercedes; Hattle, Jessica M; Izzo, Angelo; Junqueira-Kipnis, Ana Paula; Shim, Tae S; Trapnell, Bruce C; Cooper, Andrea M; Orme, Ian M 2005. Disruption of granulocyte macrophage-colony stimulating factor production in the lungs severely affects the ability of mice to control Mycobacterium tuberculosis infection. Journal of leukocyte biology, 77 6, 914-22

Jennings, Kristi; Miyamae, Takako; Traister, Russell; Marinov, Anthony; Katakura, Shigeki; Sowders, Dawn; Trapnell, Bruce; Wilson, James M; Gao, Guangping; Hirsch, Raphael 2005. Proteasome inhibition enhances AAV-mediated transgene expression in human synoviocytes in vitro and in vivo. Molecular therapy : the journal of the American Society of Gene Therapy, 11 4, 600-7

Cheng, You-Hong; Aronow, Bruce J; Hossain, Shaikh; Trapnell, Bruce; Kong, Sue; Handwerger, Stuart 2004. Critical role for transcription factor AP-2alpha in human trophoblast differentiation. Physiological genomics, 18 1, 99-107

Katakura, Shigeki; Jennings, Kristi; Watanabe, Shohei; Adachi, Eijiroh; Thornton, Sherry; Gao, Guang-Ping; Wilson, James M; Burstein, Haim; Trapnell, Bruce; Hirsch, Raphael 2004. Recombinant adeno-associated virus preferentially transduces human, compared to mouse, synovium: implications for arthritis therapy. Modern rheumatology / the Japan Rheumatism Association, 14 1, 18-24

Uchida, Kanji; Nakata, Koh; Trapnell, Bruce C; Terakawa, Takahiro; Hamano, Emi; Mikami, Ayako; Matsushita, Ikumi; Seymour, John F; Oh-Eda, Masayoshi; Ishige, Ikuo; Eishi, Yoshinobu; Kitamura, Takayuki; Yamada, Yoshitsugu; Hanaoka, Kazuo; Keicho, Naoto 2004. High-affinity autoantibodies specifically eliminate granulocyte-macrophage colony-stimulating factor activity in the lungs of patients with idiopathic pulmonary alveolar proteinosis. Blood, 103 3, 1089-98

Whitsett, Jeffrey A; Wert, Susan E; Trapnell, Bruce C 2004. Genetic disorders influencing lung formation and function at birth. Human molecular genetics, 13 Spec No 2 , R207-15

Bonfield, Tracey L; Raychaudhuri, Baisakhi; Malur, Anagha; Abraham, Susamma; Trapnell, Bruce C; Kavuru, Mani S; Thomassen, Mary Jane 2003. PU.1 regulation of human alveolar macrophage differentiation requires granulocyte-macrophage colony-stimulating factor. American journal of physiology. Lung cellular and molecular physiology, 285 5, L1132-6

Trapnell, Bruce C; Whitsett, Jeffrey A; Nakata, Koh 2003. Pulmonary alveolar proteinosis. The New England journal of medicine, 349 26, 2527-39

Berclaz, Pierre-Yves; Shibata, Yoko; Whitsett, Jeffrey A; Trapnell, Bruce C 2002. GM-CSF, via PU.1, regulates alveolar macrophage Fcgamma R-mediated phagocytosis and the IL-18/IFN-gamma -mediated molecular connection between innate and adaptive immunity in the lung. Blood, 100 12, 4193-200

Berclaz, Pierre-Yves; Zsengellér, Zsuzsanna; Shibata, Yoko; Otake, Kazuhisa; Strasbaugh, Steven; Whitsett, Jeffrey A; Trapnell, Bruce C 2002. Endocytic internalization of adenovirus, nonspecific phagocytosis, and cytoskeletal organization are coordinately regulated in alveolar macrophages by GM-CSF and PU.1. Journal of immunology (Baltimore, Md. : 1950), 169 11, 6332-42

Hassett, Daniel J; Cuppoletti, John; Trapnell, Bruce; Lymar, Sergei V; Rowe, John J; Yoon, Sang Sun; Hilliard, George M; Parvatiyar, Kislay; Kamani, Moneesha C; Wozniak, Daniel J; Hwang, Sung Hei; McDermott, Timothy R; Ochsner, Urs A 2002. Anaerobic metabolism and quorum sensing by Pseudomonas aeruginosa biofilms in chronically infected cystic fibrosis airways: rethinking antibiotic treatment strategies and drug targets. Advanced drug delivery reviews, 54 11, 1425-43

Trapnell, Bruce C 2002. Granulocyte macrophage-colony stimulating factor augmentation therapy in sepsis: is there a role? American journal of respiratory and critical care medicine, 166 2, 129-30

Trapnell, Bruce C; Whitsett, Jeffrey A 2002. Gm-CSF regulates pulmonary surfactant homeostasis and alveolar macrophage-mediated innate host defense. Annual review of physiology, 64 , 775-802

Shibata, Y; Berclaz, P Y; Chroneos, Z C; Yoshida, M; Whitsett, J A; Trapnell, B C 2001. GM-CSF regulates alveolar macrophage differentiation and innate immunity in the lung through PU.1. Immunity, 15 4, 557-67

Shibata, Y; Zsengeller, Z; Otake, K; Palaniyar, N; Trapnell, B C 2001. Alveolar macrophage deficiency in osteopetrotic mice deficient in macrophage colony-stimulating factor is spontaneously corrected with age and associated with matrix metalloproteinase expression and emphysema. Blood, 98 9, 2845-52

Zsengellér, Z K; Ross, G F; Trapnell, B C; Szabó, C; Whitsett, J A 2001. Adenovirus infection increases iNOS and peroxynitrite production in the lung. American journal of physiology. Lung cellular and molecular physiology, 280 3, L503-11

Zsengellér, Z; Otake, K; Hossain, S A; Berclaz, P Y; Trapnell, B C 2000. Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection. Journal of virology, 74 20, 9655-67

Harrod, K S; Trapnell, B C; Otake, K; Korfhagen, T R; Whitsett, J A 1999. SP-A enhances viral clearance and inhibits inflammation after pulmonary adenoviral infection. The American journal of physiology, 277 3 Pt 1, L580-8

Iwamoto, H S; Trapnell, B C; McConnell, C J; Daugherty, C; Whitsett, J A 1999. Pulmonary inflammation associated with repeated, prenatal exposure to an E1, E3-deleted adenoviral vector in sheep. Gene therapy, 6 1, 98-106

March, K L; Woody, M; Mehdi, K; Zipes, D P; Brantly, M; Trapnell, B C 1999. Efficient in vivo catheter-based pericardial gene transfer mediated by adenoviral vectors. Clinical cardiology, 22 1 Suppl 1, I23-9

Schwarz, Y A; Amin, R S; Stark, J M; Trapnell, B C; Wilmott, R W 1999. Interleukin-1 receptor antagonist inhibits interleukin-8 expression in A549 respiratory epithelial cells infected in vitro with a replication-deficient recombinant adenovirus vector. American journal of respiratory cell and molecular biology, 21 3, 388-94

Connelly, S; Andrews, J L; Gallo, A M; Kayda, D B; Qian, J; Hoyer, L; Kadan, M J; Gorziglia, M I; Trapnell, B C; McClelland, A; Kaleko, M 1998. Sustained phenotypic correction of murine hemophilia A by in vivo gene therapy. Blood, 91 9, 3273-81

Harrod, K S; Hermiston, T W; Trapnell, B C; Wold, W S; Whitsett, J A 1998. Lung-specific expression of adenovirus E3-14.7K in transgenic mice attenuates adenoviral vector-mediated lung inflammation and enhances transgene expression. Human gene therapy, 9 13, 1885-98

Otake, K; Ennist, D L; Harrod, K; Trapnell, B C 1998. Nonspecific inflammation inhibits adenovirus-mediated pulmonary gene transfer and expression independent of specific acquired immune responses. Human gene therapy, 9 15, 2207-22

Czubayko, F; Downing, S G; Hsieh, S S; Goldstein, D J; Lu, P Y; Trapnell, B C; Wellstein, A 1997. Adenovirus-mediated transduction of ribozymes abrogates HER-2/neu and pleiotrophin expression and inhibits tumor cell proliferation. Gene therapy, 4 9, 943-9

Zsengellér, Z K; Boivin, G P; Sawchuk, S S; Trapnell, B C; Whitsett, J A; Hirsch, R 1997. Anti-T cell receptor antibody prolongs transgene expression and reduces lung inflammation after adenovirus-mediated gene transfer. Human gene therapy, 8 8, 935-41

Zsengellér, Z K; Wert, S E; Bachurski, C J; Kirwin, K L; Trapnell, B C; Whitsett, J A 1997. Recombinant adenoviral vector disrupts surfactant homeostasis in mouse lung. Human gene therapy, 8 11, 1331-44

Gorziglia, M I; Kadan, M J; Yei, S; Lim, J; Lee, G M; Luthra, R; Trapnell, B C 1996. Elimination of both E1 and E2 from adenovirus vectors further improves prospects for in vivo human gene therapy. Journal of virology, 70 6, 4173-8

Jobe, A H; Ueda, T; Whitsett, J A; Trapnell, B C; Ikegami, M 1996. Surfactant enhances adenovirus-mediated gene expression in rabbit lungs. Gene therapy, 3 9, 775-9

Mittereder, N; March, K L; Trapnell, B C 1996. Evaluation of the concentration and bioactivity of adenovirus vectors for gene therapy. Journal of virology, 70 11, 7498-509

Stark, J M; Amin, R S; Trapnell, B C 1996. Infection of A549 cells with a recombinant adenovirus vector induces ICAM-1 expression and increased CD-18-dependent adhesion of activated neutrophils. Human gene therapy, 7 14, 1669-81

Wilmott, R W; Amin, R S; Perez, C R; Wert, S E; Keller, G; Boivin, G P; Hirsch, R; De Inocencio, J; Lu, P; Reising, S F; Yei, S; Whitsett, J A; Trapnell, B C 1996. Safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lungs of nonhuman primates. Human gene therapy, 7 3, 301-18

Clayman, G L; Trapnell, B C; Mittereder, N; Liu, T J; Eicher, S; Zhang, S; Shillitoe, E J 1995. Transduction of normal and malignant oral epithelium by an adenovirus vector: the effect of dose and treatment time on transduction efficiency and tissue penetration. Cancer gene therapy, 2 2, 105-11

Holzinger, A; Trapnell, B C; Weaver, T E; Whitsett, J A; Iwamoto, H S 1995. Intraamniotic administration of an adenoviral vector for gene transfer to fetal sheep and mouse tissues. Pediatric research, 38 6, 844-50

March, K L; Madison, J E; Trapnell, B C 1995. Pharmacokinetics of adenoviral vector-mediated gene delivery to vascular smooth muscle cells: modulation by poloxamer 407 and implications for cardiovascular gene therapy. Human gene therapy, 6 1, 41-53

Vincent, M C; Trapnell, B C; Baughman, R P; Wert, S E; Whitsett, J A; Iwamoto, H S 1995. Adenovirus-mediated gene transfer to the respiratory tract of fetal sheep in utero. Human gene therapy, 6 8, 1019-28

Zsengeller, Z K; Wert, S E; Hull, W M; Hu, X; Yei, S; Trapnell, B C; Whitsett, J A 1995. Persistence of replication-deficient adenovirus-mediated gene transfer in lungs of immune-deficient (nu/nu) mice. Human gene therapy, 6 4, 457-67

Mittereder, N; Yei, S; Bachurski, C; Cuppoletti, J; Whitsett, J A; Tolstoshev, P; Trapnell, B C 1994. Evaluation of the efficacy and safety of in vitro, adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA. Human gene therapy, 5 6, 717-29

Trapnell, B C; Gorziglia, M 1994. Gene therapy using adenoviral vectors. Current opinion in biotechnology, 5 6, 617-25

Yei, S; Bachurski, C J; Weaver, T E; Wert, S E; Trapnell, B C; Whitsett, J A 1994. Adenoviral-mediated gene transfer of human surfactant protein B to respiratory epithelial cells. American journal of respiratory cell and molecular biology, 11 3, 329-36

Yei, S; Mittereder, N; Tang, K; O'Sullivan, C; Trapnell, B C 1994. Adenovirus-mediated gene transfer for cystic fibrosis: quantitative evaluation of repeated in vivo vector administration to the lung. Gene therapy, 1 3, 192-200

Yei, S; Mittereder, N; Wert, S; Whitsett, J A; Wilmott, R W; Trapnell, B C 1994. In vivo evaluation of the safety of adenovirus-mediated transfer of the human cystic fibrosis transmembrane conductance regulator cDNA to the lung. Human gene therapy, 5 6, 731-44

Chu, C S; Trapnell, B C; Curristin, S; Cutting, G R; Crystal, R G 1993. Genetic basis of variable exon 9 skipping in cystic fibrosis transmembrane conductance regulator mRNA. Nature genetics, 3 2, 151-6

Erzurum, S C; Danel, C; Gillissen, A; Chu, C S; Trapnell, B C; Crystal, R G 1993. In vivo antioxidant gene expression in human airway epithelium of normal individuals exposed to 100% O2. Journal of applied physiology (Bethesda, Md. : 1985), 75 3, 1256-62

Lee, S W; Trapnell, B C; Rade, J J; Virmani, R; Dichek, D A 1993. In vivo adenoviral vector-mediated gene transfer into balloon-injured rat carotid arteries. Circulation research, 73 5, 797-807

Smith, T A; Mehaffey, M G; Kayda, D B; Saunders, J M; Yei, S; Trapnell, B C; McClelland, A; Kaleko, M 1993. Adenovirus mediated expression of therapeutic plasma levels of human factor IX in mice. Nature genetics, 5 4, 397-402

Trapnell, B C 1993. Quantitative evaluation of gene expression in freshly isolated human respiratory epithelial cells. The American journal of physiology, 264 3 Pt 1, L199-212

Bargon, J; Trapnell, B C; Chu, C S; Rosenthal, E R; Yoshimura, K; Guggino, W B; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G 1992. Down-regulation of cystic fibrosis transmembrane conductance regulator gene expression by agents that modulate intracellular divalent cations. Molecular and cellular biology, 12 4, 1872-8

Bargon, J; Trapnell, B C; Yoshimura, K; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G 1992. Expression of the cystic fibrosis transmembrane conductance regulator gene can be regulated by protein kinase C. The Journal of biological chemistry, 267 23, 16056-60

Chu, C S; Trapnell, B C; Curristin, S M; Cutting, G R; Crystal, R G 1992. Extensive posttranscriptional deletion of the coding sequences for part of nucleotide-binding fold 1 in respiratory epithelial mRNA transcripts of the cystic fibrosis transmembrane conductance regulator gene is not associated with the clinical manifestations of cystic fibrosis. The Journal of clinical investigation, 90 3, 785-90

Nakamura, H; Yoshimura, K; Bajocchi, G; Trapnell, B C; Pavirani, A; Crystal, R G 1992. Tumor necrosis factor modulation of expression of the cystic fibrosis transmembrane conductance regulator gene. FEBS letters, 314 3, 366-70

Rosenfeld, M A; Yoshimura, K; Trapnell, B C; Yoneyama, K; Rosenthal, E R; Dalemans, W; Fukayama, M; Bargon, J; Stier, L E; Stratford-Perricaudet, L 1992. In vivo transfer of the human cystic fibrosis transmembrane conductance regulator gene to the airway epithelium. Cell, 68 1, 143-55

Abe, T; Kobayashi, N; Yoshimura, K; Trapnell, B C; Kim, H; Hubbard, R C; Brewer, M T; Thompson, R C; Crystal, R G 1991. Expression of the secretory leukoprotease inhibitor gene in epithelial cells. The Journal of clinical investigation, 87 6, 2207-15

Chu, C S; Trapnell, B C; Murtagh, J J; Moss, J; Dalemans, W; Jallat, S; Mercenier, A; Pavirani, A; Lecocq, J P; Cutting, G R 1991. Variable deletion of exon 9 coding sequences in cystic fibrosis transmembrane conductance regulator gene mRNA transcripts in normal bronchial epithelium. The EMBO journal, 10 6, 1355-63

Hamosh, A; Trapnell, B C; Zeitlin, P L; Montrose-Rafizadeh, C; Rosenstein, B J; Crystal, R G; Cutting, G R 1991. Severe deficiency of cystic fibrosis transmembrane conductance regulator messenger RNA carrying nonsense mutations R553X and W1316X in respiratory epithelial cells of patients with cystic fibrosis. The Journal of clinical investigation, 88 6, 1880-5

Trapnell, B C; Chu, C S; Paakko, P K; Banks, T C; Yoshimura, K; Ferrans, V J; Chernick, M S; Crystal, R G 1991. Expression of the cystic fibrosis transmembrane conductance regulator gene in the respiratory tract of normal individuals and individuals with cystic fibrosis. Proceedings of the National Academy of Sciences of the United States of America, 88 15, 6565-9

Trapnell, B C; Zeitlin, P L; Chu, C S; Yoshimura, K; Nakamura, H; Guggino, W B; Bargon, J; Banks, T C; Dalemans, W; Pavirani, A 1991. Down-regulation of cystic fibrosis gene mRNA transcript levels and induction of the cystic fibrosis chloride secretory phenotype in epithelial cells by phorbol ester. The Journal of biological chemistry, 266 16, 10319-23

Yoshimura, K; Nakamura, H; Trapnell, B C; Chu, C S; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G 1991. Expression of the cystic fibrosis transmembrane conductance regulator gene in cells of non-epithelial origin. Nucleic acids research, 19 19, 5417-23

Yoshimura, K; Nakamura, H; Trapnell, B C; Dalemans, W; Pavirani, A; Lecocq, J P; Crystal, R G 1991. The cystic fibrosis gene has a "housekeeping"-type promoter and is expressed at low levels in cells of epithelial origin. The Journal of biological chemistry, 266 14, 9140-4

Nagaoka, I; Trapnell, B C; Crystal, R G 1990. Upregulation of platelet-derived growth factor-A and -B gene expression in alveolar macrophages of individuals with idiopathic pulmonary fibrosis. The Journal of clinical investigation, 85 6, 2023-7

Nagaoka, I; Trapnell, B C; Crystal, R G 1990. Regulation of insulin-like growth factor I gene expression in the human macrophage-like cell line U937. The Journal of clinical investigation, 85 2, 448-55

Saltini, C; Kirby, M; Trapnell, B C; Tamura, N; Crystal, R G 1990. Biased accumulation of T lymphocytes with "memory"-type CD45 leukocyte common antigen gene expression on the epithelial surface of the human lung. The Journal of experimental medicine, 171 4, 1123-40

Rom, W N; Basset, P; Fells, G A; Nukiwa, T; Trapnell, B C; Crysal, R G 1988. Alveolar macrophages release an insulin-like growth factor I-type molecule. The Journal of clinical investigation, 82 5, 1685-93

Trapnell, B C; Mavko, L E; Birskovich, L M; Falko, J M 1986. Metoclopramide suppositories in the treatment of diabetic gastroparesis. Archives of internal medicine, 146 11, 2278-9

Dalgleish, R; Trapnell, B C; Crystal, R G; Tolstoshev, P 1982. Copy number of a human type I alpha 2 collagen gene. The Journal of biological chemistry, 257 22, 13816-22

Tolstoshev, P; Berg, R A; Rennard, S I; Bradley, K H; Trapnell, B C; Crystal, R G 1981. Procollagen production and procollagen messenger RNA levels and activity in human lung fibroblasts during periods of rapid and stationary growth. The Journal of biological chemistry, 256 6, 3135-40

Tolstoshev, P; Haber, R; Trapnell, B C; Crystal, R G 1981. Procollagen messenger RNA levels and activity and collagen synthesis during the fetal development of sheep lung, tendon, and skin. The Journal of biological chemistry, 256 18, 9672-9

Boyd, C D; Tolstoshev, P; Schafer, M P; Trapnell, B C; Coon, H C; Kretschmer, P J; Nienhuis, A W; Crystal, R G 1980. Isolation and characterization of a 15-kilobase genomic sequence coding for part of the Pro alpha 2 chain of sheep type I collagen. The Journal of biological chemistry, 255 7, 3212-20

Trapnell, B C; Tolstoshev, P; Crystal, R G 1980. Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors. Nucleic acids research, 8 16, 3659-72