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Heart, Lung and Vascular Institute

Photo of  T. Douglas Mast, PhD

T. Douglas Mast, PhD

Professor, College of Engineering and Applied Sciences, Department of Biomedical Engineering

Research Interests

I have been active in biomedical ultrasound research since 1993, and currently lead the UC Biomedical Acoustics Laboratory, investigating applications of ultrasound in thermal ablation, as well as other therapeutic and diagnostic applications. My research experience and expertise includes ultrasound image guidance for thermal ablation, passive cavitation detection and imaging, ultrasound-mediated drug delivery, therapeutic ultrasound for treatment of cancer, simulation of ultrasound propagation in inhomogeneous tissue, modeling of bio-heat transfer in thermal therapy, image analysis to map mechanical displacement and strain in soft tissues, tissue characterization, inverse scattering, modeling and analysis of radiation from ultrasound transducers, and design of minimally-invasive medical devices.

Contact Information
  • 3938 Cardiovascular Center
  • 231 Albert Sabin Way
  • Cincinnati, Ohio 45267
  • Office 513-558-5609
  • Email doug.mast@uc.edu
  • UC Institute Member Seal

Peer Reviewed Publications

Fosnight, Tyler R; Hooi, Fong Ming; Keil, Ryan D; Ross, Alexander P; Subramanian, Swetha; Akinyi, Teckla G; Killin, Jakob K; Barthe, Peter G; Rudich, Steven M; Ahmad, Syed A; Rao, Marepalli B; Mast, T Douglas 2017. Echo Decorrelation Imaging of Rabbit Liver and VX2 Tumor during In Vivo Ultrasound Ablation. Ultrasound in medicine & biology, 43 1, 176-186

Haworth, Kevin J; Bader, Kenneth B; Rich, Kyle T; Holland, Christy K; Mast, T Douglas 2017. Quantitative Frequency-Domain Passive Cavitation Imaging. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 64 1, 177-191

Haworth, Kevin J; Bader, Kenneth B; Rich, Kyle Thomas; Holland, Christy K; Mast, T Douglas 2016. Quantitative Frequency-Domain Passive Cavitation Imaging. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, ,

Subramanian, Swetha; Schmidt, Daniel T; Rao, Marepalli B; Mast, T Douglas 2016. Dependence of ultrasound echo decorrelation on local tissue temperature during ex vivo radiofrequency ablation. Physics in medicine and biology, 61 6, 2356-71

Haworth, Kevin J; Salgaonkar, Vasant A; Corregan, Nicholas M; Holland, Christy K; Mast, T Douglas 2015. Using passive cavitation images to classify high-intensity focused ultrasound lesions. Ultrasound in medicine & biology, 41 9, 2420-34

Rich, Kyle T; Mast, T Douglas 2015. Accuracy of a bistatic scattering substitution technique for calibration of focused receivers. The Journal of the Acoustical Society of America, 138 5, EL469-73

Rich, Kyle T; Mast, T Douglas 2015. Methods to calibrate the absolute receive sensitivity of single-element, focused transducers. The Journal of the Acoustical Society of America, 138 3, EL193-8

Subramanian, Swetha; Mast, T Douglas 2015. Optimization of tissue physical parameters for accurate temperature estimation from finite-element simulation of radiofrequency ablation. Physics in medicine and biology, 60 19, N345-55

Hoerig, Cameron L; Serrone, Joseph C; Burgess, Mark T; Zuccarello, Mario; Mast, T Douglas 2014. Prediction and suppression of HIFU-induced vessel rupture using passive cavitation detection in an ex vivo model. Journal of therapeutic ultrasound, 2 , 14

Nagle, Anna S; Barker, Matthew A; Kleeman, Steven D; Haridas, Balakrishna; Mast, T Douglas 2014. Passive biomechanical properties of human cadaveric levator ani muscle at low strains. Journal of biomechanics, 47 2, 583-6

Rich, Kyle T; Hoerig, Cameron L; Rao, Marepalli B; Mast, T Douglas 2014. Relations between acoustic cavitation and skin resistance during intermediate- and high-frequency sonophoresis. Journal of controlled release : official journal of the Controlled Release Society, 194 , 266-77

Subramanian, Swetha; Rudich, Steven M; Alqadah, Amel; Karunakaran, Chandra Priya; Rao, Marepalli B; Mast, T Douglas 2014. In vivo thermal ablation monitoring using ultrasound echo decorrelation imaging. Ultrasound in medicine & biology, 40 1, 102-14

Haworth, Kevin J; Mast, T Douglas; Radhakrishnan, Kirthi; Burgess, Mark T; Kopechek, Jonathan A; Huang, Shao-Ling; McPherson, David D; Holland, Christy K 2012. Passive imaging with pulsed ultrasound insonations. The Journal of the Acoustical Society of America, 132 1, 544-53

Mast, T Douglas; Barthe, Peter G; Makin, Inder Raj S; Slayton, Michael H; Karunakaran, Chandra Priya; Burgess, Mark T; Alqadah, Amel; Rudich, Steven M 2011. Treatment of rabbit liver cancer in vivo using miniaturized image-ablate ultrasound arrays. Ultrasound in medicine & biology, 37 10, 1609-21

Mast, T Douglas 2010. Convolutional modeling of diffraction effects in pulse-echo ultrasound imaging. The Journal of the Acoustical Society of America, 128 3, EL99-104

Salgaonkar, Vasant A; Datta, Saurabh; Holland, Christy K; Mast, T Douglas 2009. Passive cavitation imaging with ultrasound arrays. The Journal of the Acoustical Society of America, 126 6, 3071-83

Ammi, Azzdine Y; Mast, T Douglas; Huang, I-Hua; Abruzzo, Todd A; Coussios, Constantin-C; Shaw, George J; Holland, Christy K 2008. Characterization of ultrasound propagation through ex-vivo human temporal bone. Ultrasound in medicine & biology, 34 10, 1578-89

Datta, Saurabh; Coussios, Constantin-C; Ammi, Azzdine Y; Mast, T Douglas; de Courten-Myers, Gabrielle M; Holland, Christy K 2008. Ultrasound-enhanced thrombolysis using Definity as a cavitation nucleation agent. Ultrasound in medicine & biology, 34 9, 1421-33

Mast, T Douglas; Pucke, Daniel P; Subramanian, Swetha E; Bowlus, William J; Rudich, Steven M; Buell, Joseph F 2008. Ultrasound monitoring of in vitro radio frequency ablation by echo decorrelation imaging. Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine, 27 12, 1685-97

Mast, T Douglas; Salgaonkar, Vasant A; Karunakaran, Chandrapriya; Besse, John A; Datta, Saurabh; Holland, Christy K 2008. Acoustic emissions during 3.1 MHz ultrasound bulk ablation in vitro. Ultrasound in medicine & biology, 34 9, 1434-48

Mast, T Douglas 2007. Fresnel approximations for acoustic fields of rectangularly symmetric sources. The Journal of the Acoustical Society of America, 121 6, 3311-22

Nahirnyak, Volodymyr; Mast, T Douglas; Holland, Christy K 2007. Ultrasound-induced thermal elevation in clotted blood and cranial bone. Ultrasound in medicine & biology, 33 8, 1285-95

Makin, Inder Raj S; Mast, T Douglas; Faidi, Waseem; Runk, Megan M; Barthe, Peter G; Slayton, Michael H 2005. Miniaturized ultrasound arrays for interstitial ablation and imaging. Ultrasound in medicine & biology, 31 11, 1539-50

Mast, T Douglas; Makin, Inder Raj S; Faidi, Waseem; Runk, Megan M; Barthe, Peter G; Slayton, Michael H 2005. Bulk ablation of soft tissue with intense ultrasound: modeling and experiments. The Journal of the Acoustical Society of America, 118 4, 2715-24

Tabei, Makoto; Mast, T Douglas; Waag, Robert C 2003. Simulation of ultrasonic focus aberration and correction through human tissue. The Journal of the Acoustical Society of America, 113 2, 1166-76

Jansson, Tomas; Jurkonis, Rytis; Mast, T Douglas; Persson, Hans W; Lindström, Kjell 2002. Frequency dependence of speckle in continuous-wave ultrasound with implications for blood perfusion measurements. IEEE transactions on ultrasonics, ferroelectrics, and frequency control, 49 6, 715-25

Mast, T Douglas 2002. Aberration correction for time-domain ultrasound diffraction tomography. The Journal of the Acoustical Society of America, 112 1, 55-64

Tabei, Makoto; Mast, T Douglas; Waag, Robert C 2002. A k-space method for coupled first-order acoustic propagation equations. The Journal of the Acoustical Society of America, 111 1 Pt 1, 53-63

Mast T. 12-29-1999. Wideband quantitative ultrasonic imaging by time-domain diffraction tomography Journal of the Acoustical Society of America, 106 6, 3061-3071

Mast T.D.;Hinkelman L.M.;Metlay L.A.;Orr M.J.;Waag R.C. 12-29-1999. Simulation of ultrasonic pulse propagation, distortion, and attenuation in the human chest wall Journal of the Acoustical Society of America, 106 6, 3665-3677

Mast T. 12-20-2001. Two- and three-dimensional simulations of ultrasonic propagation through human breast tissue Acoustic Research Letters Online, 3 , 53-58

Rich K.;Holland C.;Rao M.;Mast T. 12-01-2018. Characterization of cavitation-radiated acoustic power using diffraction correction Journal of the Acoustical Society of America, 144 6, 3563-3574

Hoerig C.;Serrone J.;Zuccarello M.;Burgess M.;Mast T. 12-01-2012. Acoustic emissions associated with ultrasound-induced rupture of ex vivo blood vessels Proceedings of Meetings on Acoustics, 18 ,

Karunakaran C.;Rudich S.;Alqadah A.;Burgess M.;Narmoneva D.;Mast T. 12-01-2012. Histologic analysis of rabbit liver cancer treated by bulk ultrasound ablation AIP Conference Proceedings, 1481 , 162-168

Rich K.;Hoerig C.;Mast T. 12-01-2012. Cavitation mechanisms in ultrasound-enhanced permeability of ex vivo porcine skin Proceedings of Meetings on Acoustics, 18 ,

Subramanian S.;Rudich S.M.;Alqadah A.;Karunakaran C.P.;Mast T.D. 12-01-2012. In vivo thermal ablation monitoring by echo decorrelation imaging AIP Conference Proceedings, 1481 , 374-380

Mast T.;Subramanian S. 12-01-2010. Analytic and numerical modeling of ultrasonic B-scan and echo decorrelation imaging Proceedings of Meetings on Acoustics, 9 ,

Mast T.D.;Barthe P.G.;Makin I.R.S.;Slayton M.H.;Karunakaran C.P.;Burgess M.T.;Alqadah A.;Buell J.F.;Rudich S.M. 12-01-2009. In vivo treatment of rabbit VX2 tumor by miniaturized image-ablate ultrasound arrays Proceedings - IEEE Ultrasonics Symposium, ,

Mast T.D.;Faidi W.;Makin I.R.S. 12-01-2006. Acoustic field modeling in therapeutic ultrasound AIP Conference Proceedings, 838 , 209-216

Mast T.D.;Yu F. 12-01-2005. Simplified expansions for radiation from a baffled circular piston Journal of the Acoustical Society of America, 118 6, 3457-3464

Barthe P.G.;Slayton M.H.;Jaeger P.M.;Makin I.R.S.;Gallagher L.A.;Mast T.D.;Runk M.M.;Faidi W. 12-01-2004. Ultrasound therapy system and ablation results utilizing miniature imaging/therapy arrays Proceedings - IEEE Ultrasonics Symposium, 3 , 1792-1795

Makin I.R.S.;Mast T.D.;Faidi W.;Runk M.;Barthe P.G.;Slayton M.H. 12-01-2004. B-scan imaging and thermal lesion monitoring using miniaturized dual-functionality ultrasound arrays Proceedings - IEEE Ultrasonics Symposium, 3 , 1788-1791

Mast T.;Lin F.;Waag R. 12-01-1999. Time-domain ultrasound diffraction tomography Proceedings of the IEEE Ultrasonics Symposium, 2 , 1617-1620

Mould J.;Wojcik G.;Carcione L.;Tabei M.;Mast T.;Waag R. 12-01-1999. Validation of FFT-based algorithms for large-scale modeling of wave propagation in tissue Proceedings of the IEEE Ultrasonics Symposium, 2 , 1551-1556

Douglas Mast T.;Hinkelman L.;Orr M.;Waag R. 12-01-1998. The effect of abdominal wall morphology on ultrasonic pulse distortion. Part II. Simulations Journal of the Acoustical Society of America, 104 6, 3651-3664

Hinkelman L.M.;Douglas Mast T.;Metlay L.A.;Waag R.C. 12-01-1998. The effect of abdominal wall morphology on ultrasonic pulse distortion. Part I. Measurements Journal of the Acoustical Society of America, 104 6, 3635-3649

Hinkelman L.;Mast T.;Orr M.;Waag R. 12-01-1997. Effects of abdominal wall morphology on ultrasonic pulse distortion Proceedings of the IEEE Ultrasonics Symposium, 2 , 1493-1496

Mast T.;Nachman A.;Liu D.;Waag R. 12-01-1997. Quantitative imaging with eigenfunctions of the scattering operator Proceedings of the IEEE Ultrasonics Symposium, 2 , 1507-1510

Mast T.;Pierce A. 12-01-1991. Flow-induced sounds associated with aneurysms American Society of Mechanical Engineers, Noise Control and Acoustics Division (Publication) NCA, 11 , 129-134

Mast T. 11-16-2000. Empirical relationships between acoustic parameters in human soft tissues Acoustic Research Letters Online, 1 , 37-42

Kopechek J.;Haworth K.;Raymond J.;Douglas Mast T.;Perrin S.;Klegerman M.;Huang S.;Porter T.;McPherson D.;Holland C. 11-01-2011. Acoustic characterization of echogenic liposomes: Frequency-dependent attenuation and backscatter Journal of the Acoustical Society of America, 130 5, 3472-3481

Abbass M.;Garbo A.;Mahalingam N.;Killin J.;Mast T. 10-31-2017. Real-time control of bulk ultrasound thermal ablation using echo decorrelation imaging feedback IEEE International Ultrasonics Symposium, IUS, ,

Abbass M.;Garbo A.;Mahalingam N.;Killin J.;Mast T. 10-31-2017. Real-time control of bulk ultrasound thermal ablation using echo decorrelation imaging feedback IEEE International Ultrasonics Symposium, IUS, ,

Cox M.;Abbass M.;Garbo A.;Mast T. 10-31-2017. Focused ultrasound ablation using electronically scanned grating lobes with real-time echo decorrela IEEE International Ultrasonics Symposium, IUS, ,

Cox M.;Abbass M.;Mahalingam N.;Garbo A.;Krothapalli K.;Mast T. 10-31-2017. Focused ultrasound ablation using electronically scanned grating lobes with real-time echo decorrela IEEE International Ultrasonics Symposium, IUS, ,

Mast T.;Salgaonkar V.;Karunakaran C.;Besse J.;Datta S.;Holland C. 09-24-2007. Measurements of cavitation dose, echogenicity, and temperature during ultrasound ablation AIP Conference Proceedings, 911 , 335-341

Hoerig C.;Serrone J.;Burgess M.;Zuccarello M.;Mast T. 09-08-2014. Prediction and suppression of HIFU-induced vessel rupture using passive cavitation detection in an e Journal of Therapeutic Ultrasound, 2 1,

Salgaonkar V.;Karunakaran C.;Besse J.;Heinlein G.;Datta S.;Holland C.;Mast T. 08-31-2007. Image-guided Ex vivo liver ablation by unfocused ultrasound using passive cavitation detection Progress in Biomedical Optics and Imaging - Proceedings of SPIE, 6440 ,

Mast T.;Hinkelman L.;Orr M.;Sparrow V.;Waag R. 08-01-1997. Simulation of ultrasonic pulse propagation through the abdominal wall Journal of the Acoustical Society of America, 102 2, 1177-1190

Mast T.;Nachman A.;Waag R. 08-01-1997. Focusing and imaging using eigenfunctions of the scattering operator Journal of the Acoustical Society of America, 102 2 pt 1, 715-725

Karunakaran C.;Burgess M.;Holland C.;Mast T. 07-21-2009. Role of cavitation in bulk ultrasound ablation: A histologic study AIP Conference Proceedings, 1113 , 43-47

Haworth K.;Salgaonkar V.;Corregan N.;Holland C.;Mast T. 06-19-2013. Spatial specificity and sensitivity of passive cavitation imaging for monitoring high-intensity focu Proceedings of Meetings on Acoustics, 19 ,

Abbass M.;Garbo A.;Mahalingam N.;Killin J.;Mast T. 06-14-2018. Optimized echo decorrelation imaging feedback for bulk ultrasound ablation control IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 65 10, 1743-1755

Jansson T.;Mast T.;Waag R. 06-01-1998. Measurements of differential scattering cross section using a ring transducer Journal of the Acoustical Society of America, 103 6, 3169-3179

Mast T.D.;Faidi W.;Makin I.R.S. 05-08-2006. Acoustic propagation effects in therapeutic ultrasound AIP Conference Proceedings, 829 , 3-7

Makin I.R.;Faidi W.;Mast T.D.;Runk M.;Slayton M.;Barthe P. 03-28-2005. Conformal bulk ablation and therapy monitoring using intracorporeal image-Treat Ultrasound Arrays AIP Conference Proceedings, 754 , 27-29

Fosnight T.;Hooi F.;Colbert S.;Keil R.;Barthe P.;Mast T. 03-17-2017. Echo decorrelation imaging of ex vivo HIFU and bulk ultrasound ablation using image-treat arrays AIP Conference Proceedings, 1821 ,

Heath D.;Makin I.R.;Pedapati C.;Mast T.D. 03-01-2013. Demonstration of bilateral peripheral blood flow response to physical provocation tests including os International Journal of Osteopathic Medicine, 16 1,

Al-Bataineh O.;Mast T.;Park E.;Sparrow V.;Keolian R.;Smith N. 03-01-2006. Utilization of the k-space method in the design of a ferroelectric hyperthermia phased array Ferroelectrics, 331 , 103-120

Mast T.;Gordon G. 03-01-2001. Quantitative flaw reconstruction from ultrasonic surface wavefields measured by electronic speckle p IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 48 2, 432-444

Mast T.;Souriau L.;Donald Liu D.;Tabei M.;Nachman A.;Waag R. 03-01-2001. A k-space method for large-scale models of wave propagation in tissue IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, 48 2, 341-354

Serrone J.;Kocaeli H.;Douglas Mast T.;Burgess M.;Zuccarello M. 02-01-2012. The potential applications of high-intensity focused ultrasound (HIFU) in vascular neurosurgery Journal of Clinical Neuroscience, 19 2, 214-221

Abbass M.;Killin J.;Mahalingam N.;Hooi F.;Barthe P.;Mast T. 01-01-2018. Real-Time Spatiotemporal Control of High-Intensity Focused Ultrasound Thermal Ablation Using Echo De Ultrasound in Medicine and Biology, 44 1, 199-213

Hooi F.;Nagle A.;Subramanian S.;Douglas Mast T. 01-01-2015. Analysis of tissue changes, measurement system effects, and motion artifacts in echo decorrelation i Journal of the Acoustical Society of America, 137 2, 585-597

Fosnight T.;Hooi F.;Keil R.;Subramanian S.;Barthe P.;Wang Y.;Ren X.;Ahmad S.;Rao M.;Mast T. 01-01-2014. Motion-corrected echo decorrelation imaging of in vivo focused and bulk ultrasound ablation in a rab IEEE International Ultrasonics Symposium, IUS, , 2161-2164

Subramanian S.;Schmidt D.;Fosnight T.;Rao M.;Mast T. 01-01-2013. TU?E?144?02: Dependence of Ultrasound Echo Decorrelation On Tissue Temperature During Radiofrequency Medical Physics, 40 6, 451

Gordon G.;Mast T. 01-01-1999. Wide-area imaging of ultrasonic Lamb wave fields by electronic speckle pattern interferometry Proceedings of SPIE - The International Society for Optical Engineering, 3586 , 297-309

Mast T.;Hinkelman L.;Orr M.;Sparrow V.;Waag R. 01-01-1998. Erratum: Simulation of ultrasonic pulse propagation through the abdominal wall (Journal of the Acous Journal of the Acoustical Society of America, 104 2 I, 1124

Douglas Mast T.;Pierce A. 01-01-1995. Describing-function theory for flow excitation of resonators Journal of the Acoustical Society of America, 97 1, 163-172

Mast T.;Pierce A. 01-01-1995. A theory of aneurysm sounds Journal of Biomechanics, 28 9, 1045-1053

Mast T.;Waag R. 01-01-1995. Wave space resolution in ultrasonic scattering measurements Journal of the Acoustical Society of America, 98 6, 3050-3058