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Ronald Millard, PhD.
Professor Emeritus
Ph.D., Boston University, 1969

Molecular Dynamics In Heart Failure: The research program has three areas of focused study: cardiac muscle receptors and cytoskeletal proteins, programmed cell death molecules, and the regulation of norepinephrine release and recovery by adrenergic nerves. The studies utilize animal models with spontaneous and engineered genetic defects selected protein expression in cardiac muscle cells and in adrenergic nerves. Studies are conducted in intact animals, ex vivo hearts, isolated single heart muscle cells, and in isolated cardiac adrenergic nerve vesicles or surrogate adrenergic nerve cell models. The hypotheses under investigation relate to alterations in cardiac myocyte viability and contractile performance during progressive onset of heart failure. Paradigms include the study of responses to specific receptor targeted molecules and to their effect on the evolution events that are postulated to contribute to heart failure. We monitor effects and changes with echocardiographic, hemodynamic, molecular scintigraphic, and proteomic methods.

The research program is conducted in collaboration with Myron C. Gerson, MD (Department of Internal Medicine-Cardiology and Department of Radiology-Nuclear Medicine), Lee C. Washburn, PhD (Department of Radiology-Radiochemistry), and Stephen B. Liggett, MD (Internal Medicine-Pulmonary & Critical Care Medicine).
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